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12-14 September, 2011, Lucknow - Earth Science India

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National Conference on <strong>Science</strong> of Climate Change and <strong>Earth</strong>’s Sustainability: Issues and Challenges ‘A Scientist-People Partnership’<br />

<strong>12</strong>-<strong>14</strong> <strong>September</strong>, <strong>2011</strong>, <strong>Lucknow</strong><br />

ECOFRIENDLY SYNTHESIS AND MICROBIOLOGICAL<br />

PROPERTIES OF (E)-4-(SUBSTITUTED BENZYLIDENE)-<br />

2-PHENYL-1-(5-(PYRIDIN-4-YL)-1, 3, 4-THIADIAZOL-2-<br />

YL)-1H-IMIDAZOL-5(4H)-ONE<br />

Sudhir Bhardwaj 1 , Narendra Parashar 2*, and Bharat Parashar 3<br />

1 Department of Pharmaceutical <strong>Science</strong>s, ShriRam College of Pharmacy, AB Road Banmore (Murana)<br />

M.P.<br />

2 Pacific College of Pharmacy, Udaipur, (Rajasthan)<br />

3 Department of Pharmaceutical <strong>Science</strong>s, Manav Bharati University, Solan. H.P.<br />

* email: vkparashar53@gmail.com<br />

Green chemistry is placed in the frontier areas of research and has been focused<br />

for considerable recent research. Green chemistry, the design of chemical products and<br />

processes that reduce or eliminate the use and generation of hazardous substances is an<br />

overarching approach that is applicable to all aspects of chemistry. From feedstock’s to<br />

solvents, synthesis and processing green chemistry actively seeks ways to produce<br />

materials in a way that is more begin to human health and the environment. The current<br />

emphasis on green chemistry reflects a shift away from the historic command and<br />

control approach to environmental problems that mandated waste treatment, control and<br />

clean up through regulation and towards preventing pollution at its source rather than<br />

accepting pollution at its source. Green chemistry seeks new technologies that are<br />

cleaner and economically competitive.<br />

All synthetic processes involve the use of different solvents which inevitably lead<br />

to environmental damage, through pollution, risks to human health and to resource<br />

depletion, we need to develop and apply more environmentally friendly approaches.<br />

Green chemistry involves design and redesign of chemical synthesis and chemical<br />

products to prevent pollution and thereby solve environmental problems. Clearly there<br />

will be a continuing need for the definition of novel reaction routes to both<br />

multifunctional scaffolds for lead generation and to unique drug like heterocyclic<br />

structures microwave irradiation has proved to be a powerful tool for both speeding up<br />

chemical optimizations and for efficient preparation of new target compounds.<br />

So, all traditional and old synthetic routes are more or less “Grey” in their<br />

working and obviously give adverse effects to the mankind and all living beings. Green<br />

chemistry provides “Green” paths for different synthetic routes using non-hazardous<br />

solvents and environmental friendly chemicals.<br />

The fundamentally attractive concept of green chemistry is solvent free reactions.<br />

Solvent free reactions can be accelerated by microwave activation and this combined<br />

clean technology approach to "greening" chemical reactions.<br />

87

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