12-14 September, 2011, Lucknow - Earth Science India
12-14 September, 2011, Lucknow - Earth Science India
12-14 September, 2011, Lucknow - Earth Science India
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National Conference on <strong>Science</strong> of Climate Change and <strong>Earth</strong>’s Sustainability: Issues and Challenges ‘A Scientist-People Partnership’<br />
<strong>12</strong>-<strong>14</strong> <strong>September</strong>, <strong>2011</strong>, <strong>Lucknow</strong><br />
GREEN CHEMICAL APPROACH TO SYNTHESIZE 4-<br />
(SUBSTITUTED-BENZYLIDENE-2-PHENYL-1-(5-<br />
PHENYLTHIAZOL-2-YL)-1H-IMIDAZOL-5(4H)-ONE AND<br />
ITS ANTIMICROBIAL STUDIES<br />
Kumudini Bhanat 1* , Narendra Parashar 2 , Bharat Parashar 3 and<br />
V. K. Sharma 1<br />
1 Microwave Chemistry Laboratory, Department Of Chemistry, M.L. Sukhadia University, Udaipur,<br />
(Rajasthan)<br />
2 Pacific College of Pharmacy, Udaipur, Rajasthan<br />
3 Department of Pharmaceutical <strong>Science</strong>s, Manav Bharati University, Solan. H.P.<br />
*email : kumudini23@gmail.com<br />
One of the most attractive concepts in chemistry for sustainability is Green<br />
Chemistry, which is the utilization of a set of principles that reduces or eliminates the<br />
use or generation of hazardous substances in the design, manufacture, and applications<br />
of chemical products. One of the key areas of Green Chemistry is the elimination of<br />
solvents in chemical processes or the replacement of hazardous solvents with<br />
environmentally benign solvents. Microwave heating has attracted the attention of<br />
investigators in that it makes it possible to shorten the length of reactions significantly,<br />
to increase their selectivity, and to increase the product yields, which is particularly<br />
important in the case of high-temperature processes that take a long time.<br />
Reactions in microwave ovens are currently in use for the synthesis of<br />
medicinally important compounds. Within the framework of ‘Green Chemistry’ we<br />
have now developed an environmentally benign and novel approach for the synthesis of<br />
(E)-4-(substituted benzylidene)-2-phenyl-1-(5-phenylthiazol-2-yl)-1H-imidazol-5(4H)-<br />
one. These compounds have been prepared by the reaction of 5-(pyridin-4-yl)-1,3,4-<br />
thiadiazol-2-amine with various (Z)-4-(substituted benzylidene)-2-phenyloxazol-5(4H)-<br />
one by using modified domestic microwave oven. The structure of these compounds<br />
was assigned on the basis of elemental analysis, IR, 1 H NMR spectral data. The<br />
compounds showed significant antibacterial and antifungal activity against E. coli, P.<br />
aeruginosa, S. aureus , C. albicans and A. niger using cup plate and agar well diffusion<br />
technique.<br />
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