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12-14 September, 2011, Lucknow - Earth Science India

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National Conference on <strong>Science</strong> of Climate Change and <strong>Earth</strong>’s Sustainability: Issues and Challenges ‘A Scientist-People Partnership’<br />

<strong>12</strong>-<strong>14</strong> <strong>September</strong>, <strong>2011</strong>, <strong>Lucknow</strong><br />

GREEN CHEMICAL APPROACH TO SYNTHESIZE 4-<br />

(SUBSTITUTED-BENZYLIDENE-2-PHENYL-1-(5-<br />

PHENYLTHIAZOL-2-YL)-1H-IMIDAZOL-5(4H)-ONE AND<br />

ITS ANTIMICROBIAL STUDIES<br />

Kumudini Bhanat 1* , Narendra Parashar 2 , Bharat Parashar 3 and<br />

V. K. Sharma 1<br />

1 Microwave Chemistry Laboratory, Department Of Chemistry, M.L. Sukhadia University, Udaipur,<br />

(Rajasthan)<br />

2 Pacific College of Pharmacy, Udaipur, Rajasthan<br />

3 Department of Pharmaceutical <strong>Science</strong>s, Manav Bharati University, Solan. H.P.<br />

*email : kumudini23@gmail.com<br />

One of the most attractive concepts in chemistry for sustainability is Green<br />

Chemistry, which is the utilization of a set of principles that reduces or eliminates the<br />

use or generation of hazardous substances in the design, manufacture, and applications<br />

of chemical products. One of the key areas of Green Chemistry is the elimination of<br />

solvents in chemical processes or the replacement of hazardous solvents with<br />

environmentally benign solvents. Microwave heating has attracted the attention of<br />

investigators in that it makes it possible to shorten the length of reactions significantly,<br />

to increase their selectivity, and to increase the product yields, which is particularly<br />

important in the case of high-temperature processes that take a long time.<br />

Reactions in microwave ovens are currently in use for the synthesis of<br />

medicinally important compounds. Within the framework of ‘Green Chemistry’ we<br />

have now developed an environmentally benign and novel approach for the synthesis of<br />

(E)-4-(substituted benzylidene)-2-phenyl-1-(5-phenylthiazol-2-yl)-1H-imidazol-5(4H)-<br />

one. These compounds have been prepared by the reaction of 5-(pyridin-4-yl)-1,3,4-<br />

thiadiazol-2-amine with various (Z)-4-(substituted benzylidene)-2-phenyloxazol-5(4H)-<br />

one by using modified domestic microwave oven. The structure of these compounds<br />

was assigned on the basis of elemental analysis, IR, 1 H NMR spectral data. The<br />

compounds showed significant antibacterial and antifungal activity against E. coli, P.<br />

aeruginosa, S. aureus , C. albicans and A. niger using cup plate and agar well diffusion<br />

technique.<br />

61

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