PRINCIPLES OF TOXICOLOGY - Biology East Borneo

584 INDEXEstrogens:endocrine disruption research and sperm cellcounts, 233-23.5female reproductive toxicology and suppression of,222. 223male reproductive toxicology and, 2 17Ethane- 1,2-dimethanesulfonate (EDS), Leydig celltoxicology, 2 15Ethanol:cancer risk and 315chemical interactions with, 21female reproductive toxicology, 222-223fetal alcohol sydrome, 230male reproductive toxicology, 2 16-2 17neurotoxicity, 15 l-l 52toxicology, 383Ethers, toxicology, 390- 391Ethical issues, for occupational health practices,5077508Ethylenediaminetetraacetic acid (EDTA), metalsmetabolism and storage, 330Ethylene dibromide (EDB), sperm cell development,cell-type specific toxicity, 214Ethylene glycol monoethyl ether (EGME), sperm celldevelopment, cell-type specific toxicity, 214Ethylene oxide:as fumigant, 362spontaneous abortion and 227Ethyl ether, toxicology, 39 1Euchromatin, chromosome structure and function,244Evaluation of hazardous effects, occupational healthhazards control and 533-536Exbhange initiation, chromosomal aberrations, 25 1Excretion:metals, 330-331solvent exposure, 3722373toxic agent elimination, 5 l-53kidney excretion, 51-52liver excretion, 52-53lung excretion, 53Excretion ratio; nephrotoxicity measurement, 136Exhaust systems:carbon dioxide exposure studies, 547-549control technologies for hazardous materials,5388540Experimental studies, characteristics of, 514Exposure:defined, 4epidemiologic studies of, 5 14.-5 15Exposure assessment:defined 439epidemiologic studies and frequencymeasurements, 5 1665 17national guidelines and formulas for, 447449risk assessment, exposure pathways and dosages,439,445449Exposure conditions:dose-response data, 26solvent exposure, 367-368Exposure measurement techniques, risk assessmentstudies, 446449Exposure modeling techniques, risk assessmentstudies, 4466449Exposure monitoring, evaluation of hazardous effects,534-536Exposure routes:dose-response data, organism-related factors,22-23epidemiologic studies of, 5 14-5 15risk assessment procedures, 441pathways and resulting dosages, 445449Safe Human Dose (SHD) calculations, 29-30Eye toxicity, 1655167Facilitated diffusion, toxic agents, 40False-negative/false-positive results, carcinogenbioassays, 290-291“Farmer’s lung,” 184Fats, diet and carcinogenicity, 3 16-3 17Fatty acid synthesis, fatty liver, 121Fatty liver, hepatotoxicity and 120-121Female reproductive system, reproductive toxicology,2 188224hormonal regulation, 221-223oocyte toxicity, 2 19somatic ovarian and reproductive tract toxicity,219-221toxicants table, 224Fertilization, genetic toxicology and, 244-245Fetal alcohol sydrome, teratogenic toxicants and, 230Fetal hydantoin syndrome, developmental toxicologyand, 229Fetus:epidemiologic studies and, 5 16toxic responses of, 228-23 1Fiberglass layup operation, occupational hazardcontrol case study of, 546-547Fibromas, hepatoxicity and, 123Fibrosis:industrial-related exposure, 18 1occupation-related allergic reactions, 184Fire ants, venom toxicology, 427First-pass effect:dose-response data, exposure routes, 22-23hepatotoxicity, 111natural venoms and toxins toxicity, 414Fish venoms and toxins, toxicology, 425426Flavoproteins:biotransformation, oxidation reactions, 65-66monooxygenase compounds, 66,70Flowering plants, toxicology of, 419422alkaloid toxins, 42 1cardiac glycosides and saponins, 4 19942 1peptideiprotein toxins, 42 l-422Fluorescent antinuclear antibody assay (FANA),immunotoxicity assessment, 197Folic acid, developmental toxicology and, 230