2007 - Instituto de Investigación Sanitaria La Fe

Diferenciación de células troncales embrionariashumanas a hepatocitos. Aplicación a la caracterizaciónde la homeoproteina Hex.IP: B Roque Bort.Entidad: Proyecto SAF2007-64414. Ministerio deEducación y Ciencia.PUBLICACIONESFernández-Veledo S, Jover R, Casado FJ, Gómez-Lechón MJ, Pastor-Anglada M. “Transcription factorsinvolved in the expression of SLC28 genes inhuman liver parenchymal cells”. Biochem Bioph ResCommun. 353: 381-388; 2007.Gómez-Lechón MJ, Donato MT, Martínez-RomeroA, Jiménez N , Castell JV , O´Connor E. “A humanhepatocellular in vitro model to investigate steatosis”.Chem-Biol Interact 165: 106-116; 2007.Donato MT, Jiménez N, Serralta A, Mir J, Castell JV,Gómez-Lechón MJ. “Effects of steatosis on drugmetabolizingcapability of primary human hepatocytes”.Toxicol In vitro 21: 271-276; 2007.Taléns-Visconti R, Bonora A , Jover R, Mirabet V, CarbonellF, Castell JV, Gómez-Lechón MJ. “Toxicol Human mesenchymalstem cells from adipose tissue: Differentiationinto hepatic lineage”. Toxicol In vitro 21:330-334; 2007.Martínez-Jiménez P, Jover R, Donato MT, CastellJV, Gómez-Lechón MJ. “CYP3A4 regulation andexpression in hepatocytes C”. Curr Drug Metab. 8:185- 195; 2007.Hewitt NJ, Gómez-Lechón MJ, Houston JB, HallifaxD, Brown HS, Maurel P, McGee B, Lloyd S, HewittPG, Hengstler JG. “Primary hepatocytes: Current understandingof the regulation of metabolic enzymes,transporter proteins and how they are used in pharmaceuticalpractice”. Drug Metab 39: 159-234; 2007.Gómez-Lechón MJ, Lahoz A, Donato MT. “In vitroscreening of drug metabolism in drug development”.Screening Trends in Drug Discovery 8: 32-33; 2007.Gómez-Lechón MJ, Donato MT. “In vitro investigationof drug metabolism and toxicity in man”. Analesde la Real Academia Nacional de Farmacia 73:5-26; 2007.Gómez-Lechón MJ, Castell JV, Donato MT. “Hepatocytesthe choice to investigate drug metabolism andtoxicity in man: In vitro variability as a reflection of invivo”. Chem-Biol Interact 168: 30-50; 2007.Tomás M, Marín MP, Portolés M, Megías L, Gómez-Lechón MJ, Renau-Piqueras J. “Ethanol affectscalmodulin and the calmodulin-binding proteinsneuronal nitricoxide synthase and alphaII-spectrin(alpha-fodrin) in the nucleus of growing and differentiatedrat astrocytes in primary culture”. Toxicol InVitro 21: 1039-1049; 2007.Gómez-Lechón MJ. “El transplante celular hepático:reto terapeútco del siglo XXI en medicina regenerativa”.Biomédica 6: 18-32; 2007.Rodeiro I, Donato MT, Jiménez N, Garrido G, DelgadoR, Gómez-Lechón MJ. “Efects of Mangifera indica L.aqueous extract (Vimang) on primary culture of rat hepatocytes”.Food Chem Toxicol 45: 2506-2512; 2007.Lahoz A, Donato MT, Picazo L, Gómez-Lechón MJ,Castel, JV. “Determination of major human cytochromeP450s activities in 96-well plates using liquidchromatography tandem mass spectrometry”. ToxicolIn vitro 21: 1247-1252; 2007.Rodeiro I, Donato MT, Lahoz A, González-LavautJA, Laguna A, Castell JV, Delgado R, Gómez-LechónMJ. “Modulation of P450 enzymes by Cubannatural products rich in polyphenolic compounds inrat hepatocytes”. Chem Biol Interact; 2007.OTROS MÉRITOSPa rt i c i pa c i ó n e n Se s i o n e s Pl e n a r i a s y simposiosRamiro Jover. What controls the hepatocyte adultphenotype? Invited speaker. 1st European Meeting.Human Hepatocyte Transplantation. Valencia. 10-11Noviembre 2007.XIX Congreso de la Sociedad Española de TransplanteHepático. Valladolid, 2007. J. V. Castell ConferencianteInvitado.Or g a n i z a c i ó n d e c o n g r e s o s, r e u n i o n e s, c u r s o s ys e m i n a r i o sReunión final del proyecto Short-term models assaysfor long-term toxicity (2005-2007). VI ProgramaMarco de UE (ref. LSHB-CT-2004-504761;Predictomics). Valencia, diciembre 2007.Reunión inaugural del proyecto Development of ahigh throughput genomics-based test for assessinggenotoxic and carcinogenic properties of80 - Fundación para la Investigación del Hospital Universitario La Fe - Memoria 2007