Diagnosis and Management of Infantile Hemangioma

Table 29. Key resolution outcomes in comparative studies of photothermolysis with intense
pulsed light and cryosurgery
Author, Age,
Year Months
Methods and Measures
Location
Resolution Outcomes
Groups (n)
of Resolution/Response
Quality Type
Ryzhevskiy
et al. 219
G1: Selective
photothermol
ysis (87)
G2: Cyrodestruction
with liquid
nitrogen (79)
G3:
Combination
of selective
photothermol
ysis and
sclerosis(84)
Age mean
(range)
G1+G2: 9
(3 months
to 4 years)
Type, %
Cutaneous
G1+G2:
100
Quality:
Poor
G = group; NR = not reported
G1+G2:
multiple
• Lesion area measured
with graph paper.
Change in depth
confirmed by
ultrasound
• Cosmetic results after
first treatment session:
Good: 50% or more
reduction in area;
Satisfactory: 10-50%
reduction;
Unsatisfactory: < 10%
or no positive
dynamics
• Evaluation blinding:
NR
Resolution after session 1, %
Good
G1: 35.6
G2: 22.8
G3: 71.4
Satisfactory
G1: 44.8
G2: 46.8
G3: 23.8
Unsatisfactory
G1: 19.5
G2: 30.4
G3: 4.8
Cryosurgery Versus No Treatment
One study assessed cryosurgical treatment of IH in preterm infants with multiple IH by
treating one IH lesion and not treating another. 220 Some children had more than one pair of
treated/untreated lesions, and the study followed infants up to age 1 or 2 years. Thirteen of 17
treated IH and two of 17 untreated IH met the primary endpoint of intact, IH-free skin with mild
or no pigmentation or scarring at 1 or 2 years of age (p