Diagnosis and Management of Infantile Hemangioma

For harms, a moderate strength of evidence was noted for pigmentation changes with PDL,
which was most frequently hypopigmentation. Low SOE was noted for bleeding in the
immediate postoperative period. Due to low sample size and limitations in reporting, pain and
scarring were found to have insufficient SOE. For Nd:YAG lasers, evaluation for scarring was
most frequently reported, and there was low SOE to support no difference in scarring between
Nd:YAG and observation. Evidence was deemed insufficient to comment on pigmentation
changes and bleeding for children treated with Nd:YAG and scarring after cryotherapy.
Most surgical case series (n=13) were retrospective and included a total of 838 children. We
considered all to be poor quality for harms reporting. Frequently reported harms included
scarring and wound dehiscence. SOE was insufficient for the association of surgical approaches
with harms given the small numbers of harms reported (Table 39).
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