Diagnosis and Management of Infantile Hemangioma

Table 37. Strength of evidence for harms of beta-blockers (continued)
Intervention
Atenolol
Outcome
Study Design
Quality and Number of
Studies (N Total)
Hypotension
Cohort studies: 1 poor 147 (58)
Minor harms (cold
extremities, diarrhea, sleep
changes)
RCT: 1 poor 102 (23)
Cohort studies: 1 poor 147 (58)
Study
Limitations
Consistency Directness Precision
Reporting
Bias
Finding
Strength of Evidence
Grade
High Unknown Direct Imprecise NA Hypotension reported in
3% of children in one
study.
Insufficient SOE for
association with
hypotension given only a
single, small poor quality
study.
High Consistent direct Imprecise Undetected Minor hams occurred in
7%-27% of children.
IH = infantile hemangioma; n = number; NA = not applicable; RCT = randomized, controlled trial; SOE = strength of evidence
Low SOE for the lack of
association with minor
harms given two small
studies with high
limitations.
92