Diagnosis and Management of Infantile Hemangioma

Table 11. Resolution outcomes in studies comparing beta-blockers and steroids (continued)
Author, Year
Comparison Groups
(n)
Quality
Malik et al. 2013 100
G1: Propranolol, oral 2-
3/mg/kg/day in two daily
doses (10)
G2: Prednisolone, oral
1-4 mg/kg/day (10)
G3: Propranolol, oral 2-
3/mg/kg/day and
Prednisolone, oral 1-4
mg/kg/day (10)
Quality: Fair
Rossler et al, 2012 132,133
G1: Oral propranolol, 2
mg/kg/day (30)
G2: Oral prednisone, 2
mg/kg/day then reduced
to 1 mg/kg/day (30)
Quality: Poor
Age, Months
Type
Age, mean
G1: 4.6
G2: 5.5
G3: 4.7
Type, %
Superficial
G1+G2+G3:
53
Mixed
G1+G2+G3:
26.7
Deep
G1+G2+G3:
20
Age, mean
G1: 4.4
G2: 2.8
Type: NR
Location
G1+G2+G
3: multiple
G1+G2:
multiple
Methods and
Measures of
Resolution/
Response
• Photographs
assessed by 2
blinded assessors
• Color and size
based on Visual
Analog Scale
(VAS)
• Improvement
graded as:
75-100%
50-74%
25-49%
0-24%
• Size measuring
length and width
• Blinded
assessment: NR
• IH score based on
color, skin level,
and turgor (scale
0-6)
Resolution
Outcomes
Mean size
reduction %, VAS
G1: 89.8
G2: 66.6
G3: 82.6
Color fading, VAS
G1: -9
G2: -8
G3: -9
Median size at
end of therapy
G1: 2.0 cm 2
G2: 3.5 cm 2
G1 vs G2:
p=0.006
Median score
G1: 2
G2: 3
G1 vs G2:
p