Diagnosis and Management of Infantile Hemangioma

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Author, Year Representativeness of exposed cohort Selection of non-exposed cohort Ascertainment of exposure Outcome of interest not present at start of study Comparability of cohorts Assessment of outcome Followup long enough Adequacy of follow-up of cohorts Quality Rating Nicolai 2005 38 Vlachakis 2004 39 Akyuz 2001 40 Chang 2001 41 Raulin 2001 42 Truly representative Truly representative Truly representative No description of the derivation of cohort No description of the derivation of cohort Drawn from same community Drawn from same community Drawn from same community Drawn from same community Drawn from same community Secure record Yes Cohorts not comparable Secure record Yes Cohorts not comparable Self report Yes Subjects lost to follow up unlikely to introduce bias Record linkage Secure record Yes Controls for age Record linkage Secure record Yes Cohorts not comparable Secure record Yes Cohorts not comparable Independent blind assessment Record linkage Yes Yes Yes Yes Complete follow-up Complete follow-up Complete follow-up Subjects lost to follow up unlikely to introduce bias Poor Fair Fair Poor Poor Achauer 1997 43 Truly representative Drawn from same community Secure record Yes Cohorts not comparable Record linkage No Complete follow-up Poor Achauer 1989 44 Selected group Drawn from same community Secure record Yes Cohorts not comparable Record linkage Yes Subjects lost to follow up unlikely to introduce bias Poor Table F-3. Quality assessment of studies reporting harms F-5
Author, Year Were the harms predefined using standardized or precise definitions? Were all pre-specified harms reported? Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection? Were the statistical methods used to assess the main harm or adverse event outcomes adequate? Rating Chen 2015 45 Chen 2015 46 Leaute-Labreze 2015 1 Raphael 2015 47 Tawfik 2015 2 Xu 2015 48 Abarzua-Araya 2014 3 Andersen 2014 49 Bauman 2014 4 Chai 2014 50 Chen 2014 51 Chu 2014 52 Couto 2014 53 El Ezzi 2014 54 Partial Unclear Partial Yes Poor No Unclear Unclear Yes Poor Yes Yes Yes Yes Good Partial Unclear Partial Yes Poor Partial Unclear Partial Yes Poor Partial Unclear Partial No Poor Partial Unclear Partial Yes Poor Unclear Unclear Unclear Yes Poor Yes Yes Yes Yes Good Partial Unclear Partial Yes Poor Yes Yes Unclear Yes Fair Partial Unclear Partial Yes Poor No Unclear No No Poor Partial Unclear Partial Yes Poor F-6
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Comparative Effectiveness Review Nu
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This report is based on research co
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Acknowledgments The authors gratefu
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Peer Reviewers Prior to publication
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BCI; moderate SOE for effects of pr
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Overview of the Literature ........
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Executive Summary Introduction Infa
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for contextual questions as few eff
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Figure B. Analytic framework for KQ
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Table A. Inclusion criteria (contin
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precision (precise, imprecise), and
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Figure D. Estimates of expected IH
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majority of studies to date have in
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effectiveness outcomes. The evidenc
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changes. We considered the strength
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Table C. Summary of evidence in stu
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Table D. Summary of evidence in stu
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Applicability We set inclusion crit
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quantitative meta-analyses. Researc
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surgically. Lesion characteristics
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References 1. Wassef M, Blei F, Ada
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39. Yu L, Li S, Su B, et al. Treatm
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modalities. The questions of imagin
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KQ2. Among newborns, infants, and c
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of data, and compiling evidence. We
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We only included studies published
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a standardized form (Appendix B) th
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Determining Quality Ratings • We
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Results We present results for Cont
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defects, urogenital anomalies, ulce
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Results of Literature Searches for
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Table 3. Characteristics of include
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scans, had a sensitivity of 20 perc
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of the model fit to all studies, bu
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Detailed Analysis Effectiveness of
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Table 6. Key resolution outcomes in
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with prednisolone included endocrin
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children in 8 studies), skin atroph
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hypopigmentation, impaired wound he
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fair quality for effectiveness outc
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studies of nadolol and atenolol. No
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Table 10. Key resolution outcomes i
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old. 100 Thirty percent of children
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Table 11. Resolution outcomes in st
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Table 15. Key outcomes in studies c
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Table 22. Harms/adverse effects in
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Table 24. Adverse effects in case s
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Table 24. Adverse effects in case s
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• In two RCTs reporting level of
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Nd:YAG Laser With Cooling Compared
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long term follow information was av
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Discussion State of the Literature
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Table 34. Strength of evidence for
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Effectiveness and Harms of Beta-Blo
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older children. One comparative stu
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case series reporting on rarer pres
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agents is critical, especially as u
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References 1. Wassef M, Blei F, Ada
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39. Chen TS, Eichenfield LF, Friedl
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80. Mai HM, Zheng JW, Wang YA, et a
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119. Sharma LK, Dalal SS. Corticost
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162. Snir M, Reich U, Siegel R, et
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198. Chen ZG, Zheng JW, Yuan ML, et
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237. Healy G, McGill T, Friedman EM
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Abbreviations and Acronyms Used in
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Appendix A. Search Strategies Searc
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Searches for Comparative Effectiven
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Appendix B. Screening and Quality A
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Harms Risk of Bias Assessment Form
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QUADAS Diagnostic Accuracy Rating T
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Infantile Hemangioma CER: Risk of B
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20. Grundfest-Broniatowski S, Carey
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65. Dachman AH, Lichtenstein JE, Fr
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111. Yoshida T, Kuratomi K, Mitsuma
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160. Newman SL, Goodwin CD. Colonic
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204. Crockett DM, Healy GB, McGill
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253. Wright GL, Smith RJ, Katz CD,
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301. Paley D, Jackson RW. Synovial
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346. Dombrowski MP, Budev H, Wolfe
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390. Stringel G. Giant hemangioma:
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436. Liu HC, Chang MH, Lue HC, et a
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480. Casale AJ, Menashe DS. Massive
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526. Taylor RS, Joseph DB, Kohaut E
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571. Goldstein MH. The elastic flap
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614. Salloum E, Flamant F, Caillaud
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659. Fellows KE, Hoffer FA, Markowi
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706. Weatherford DA, Abrams RS, Wal
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749. Keleti D, Flickinger JC, Hobso
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793. Van Campenhout I, Patriquin H.
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836. Goldman MP, Fitzpatrick RE, Ru
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880. Schulman SR, Jones BR, Slotnic
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924. Egawa H, Berquist W, Garcia-Ke
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968. Thompson DN, Taylor WF, Haywar
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1013. Gregg CM, Wiatrak BJ, Koopman
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1826. McQueen CT, Cullen RD. Endosc
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1866. Tsao MN, Schwartz ML, Bernste
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1950. Mounayer C, Benndorf G, Bisdo
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1992. Woo SJ, Kim CJ, Yu YS. Cavern
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2036. Ersoy S, Mancini AJ. Hemifaci
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3201. Nale P. Propranolol treatment
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Page 339 and 340: 3367. Gross BC, Janus JR, Orvidas L
Page 341 and 342: 3407. Kupeli S. Use of propranolol
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Page 367 and 368: 3930. Weil AG, Bhatia S. Resection
Page 369 and 370: 3969. Ravenscroft J. Management of
Page 371 and 372: where ΦΦ(xx) is the cumulative di
Page 373 and 374: Figure D-1. Estimates of expected I
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Page 403 and 404: 120. Pandey A, Gangopadhyay AN, Gop
Page 405 and 406: Appendix G. Applicability Tables Ta
Page 407 and 408: Appendix H. Harms Reported in Packa
Page 409 and 410: o Acquired (autoimmune) hemolytic a
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Page 415 and 416: Elocon® (mometason e furoate) 11 T
Page 417 and 418: Timoptic® (timolol maleate) 15 Tim
Page 419 and 420: Harms Data for Medications Included
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Page 429 and 430: acute myocardial infarction: 3 (Rat
Page 431 and 432: Discontinuations Patients utilizing
Page 433 and 434: ocular irritation including blephar
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Diagnosis and Management of Infantile Hemangioma

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