Diagnosis and Management of Infantile Hemangioma

a series of 43 infants with IH, 27 had at least 10 cutaneous IH (median=16) and 16 had between
five and nine cutaneous lesions (median=6.5). 82 Among the nine children treated for their IH, 9
had internal IH (8 hepatic, 1 splenic), and five of the nine had more than one internal lesion. All
of these children had ≥10 cutaneous IH and had no symptoms of internal IH. The study does not
clearly report if any internal IH were reported among the children who did not receive treatment
for cutaneous IH.
In a prospective case series including 201 infants between 0 and 6 months of age with IH
seen at specialty pediatric dermatology clinics, 24 of the 151 (16%) infants with at least five
cutaneous IH had hepatic IH, while none of the children with one to four IH had hepatic
involvement (p=0.003). 71 Preterm birth (< 37 weeks gestation) and lower birth weight were
associated with having five or more cutaneous IH (p values