Diagnosis and Management of Infantile Hemangioma

Harms most frequently reported with beta-blockers included hypotension, hypoglycemia,
bradycardia, sleep disturbances, cold extremities, gastrointestinal symptoms, and bronchial
irritation (classified as hyperreactivity, bronchospasm, bronchiolitis, cold induced wheezing).
Harms generally were not severe enough to cause treatment discontinuation (n=75/4872 children
receiving beta-blockers [1.5%]) in case series and comparative studies). We considered the SOE
to be moderate for the association of propranolol with clinically important and minor harms
(Table 37).
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