Diagnosis and Management of Infantile Hemangioma

Table 11. Resolution outcomes in studies comparing beta-blockers and steroids
Author, Year
Comparison Groups
(n)
Quality
Baumann et al. 2014 98
G1: Propranolol,
2mg/kg/day in 3 daily
doses (11)
G2: Prednisolone,
2mg/kg/day in two daily
doses (8)
Quality: Good
Age, Months
Type
Age, mean
(95% CI)
G1: 2.5 (1.7-
3.4)
G2: 4.0 (2.8-
5.2
Type, n:
Superficial
G1: 3
G2: 2
Location
G1+G2:
multiple
Methods and
Measures of
Resolution/
Response
• Size measured by
proportional
change in total
surface area
(TSA) by blinded
assessors
Resolution
Outcomes
Change in size at
4-5 months, TSA
mean (95% CI)
G1: 0.57 (0.34 to
0.80) n=9
G2: 0.63 (0.14 to
1.11) n=6
G1 vs. G2: p=ns
Rebound
Growth/
Recurrence,
n
Other
Outcomes,
n (%)
G1: 2
G2: 1
Mixed
G1: 6
G2: 4
Deep
G1: 2
G2: 2
Bertrand et al. 2011 96
G1: Propranolol, oral
2.7 mg/kg/day (12)
G2: Prednisone, oral
2.8 mg/kg/day (12)
Quality: Fair
Age, mean
(range)
G1: 3.7 (1.5-
8.7)
G2: 3.8 (1-9)
Type, n:
Superficial
G1+G2: 2
pairs
Mixed
G1+G2: 6
pairs
Deep
G1+G2: 4
pairs
G1+G2:
multiple
• Photographs rated
by blinded
assessors for
percentage of
improvement
Stable or worse
(0%)
Slight
improvement
(75%)
• Visual analog
scale (VAS) used
at 6 months (100
complete
resolution, 0 no
change, -100
doubling in size)
Clinical
improvement
VAS, mean ± SD
G1: 78.73 ± 22.47
G1: 44.82 ± 12.21
G1 vs.G2
ICC=0.833 p<
0.001
Good to excellent
response at 6
months, n
G1: 12
Slight to moderate
response
G2: 9
NR
43