Diagnosis and Management of Infantile Hemangioma

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Author, Year Were the harms predefined using standardized or precise definitions? Were all pre-specified harms reported? Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection? Were the statistical methods used to assess the main harm or adverse event outcomes adequate? Rating Raulin 2001 42 Chen 2000 136 Poetke 2000 137 Blei 1999 138 Boon 1999 139 Zide 1997 140 Gangopadhyay 1996 141 Sadan 1996 142 Chowdri 1994 143 Morelli 1994 144 Preeyanont 1994 145 Morrell 1991 146 Kushner 1990 147 Achauer 1989 44 Yes Yes Yes Yes Good No Unclear No Yes Poor No Unclear Unclear Yes Poor Partial Unclear Partial Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear No Yes Poor No Unclear Unclear Yes Poor No Unclear No No Poor No Unclear No Yes Poor No Unclear No Yes Poor Yes Yes Yes Yes Good F-15
Author, Year Were the harms predefined using standardized or precise definitions? Were all pre-specified harms reported? Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection? Were the statistical methods used to assess the main harm or adverse event outcomes adequate? Rating Sloan 1989 148 Kushner 1985 149 Healy 1984 150 Sharma 1983 151 No Unclear No Yes Poor No Unclear No No Poor No Unclear No Yes Poor No Unclear Unclear Yes Poor References 1. Léauté-Labrèze C, Hoeger P, Mazereeuw-Hautier J, et al. A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma. New England Journal of Medicine 2015;372(8):735-46. PMID: 25693013. 2. Tawfik AA, Alsharnoubi J. Topical Timolol Solution Versus Laser in Treatment of Infantile Hemangioma: A Comparative Study. Pediatr Dermatol 2015 Mar 5PMID: 25740672. 3. Abarzua-Araya A, Navarrete-Dechent CP, Heusser F, et al. Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study. J Am Acad Dermatol 2014 Jun;70(6):1045-9. PMID: 24656727. 4. Bauman NM, McCarter RJ, Guzzetta PC, et al. Propranolol vs prednisolone for symptomatic proliferating infantile hemangiomas: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg 2014 Apr;140(4):323-30. PMID: 24526257. 5. Chan H, McKay C, Adams S, et al. RCT of timolol maleate gel for superficial infantile hemangiomas in 5- to 24-week-olds. Pediatrics 2013 Jun;131(6):e1739-47. PMID: 23650294. 6. Kessels JP, Hamers ET, Ostertag JU. Superficial hemangioma: pulsed dye laser versus wait-and-see. Dermatol Surg 2013 Mar;39(3 Pt 1):414-21. PMID: 23279058. 7. Leaute-Labreze C, Dumas de la Roque E, Nacka F, et al. Double-blind randomized pilot trial evaluating the efficacy of oral propranolol on infantile haemangiomas in infants < 4 months of age. Br J Dermatol 2013 Jul;169(1):181-3. PMID: 23301692. 8. Malik MA, Menon P, Rao KL, et al. Effect of propranolol vs prednisolone vs propranolol with prednisolone in the management of infantile hemangioma: a randomized controlled study. J Pediatr Surg 2013 Dec;48(12):2453-9. PMID: 24314186. F-16
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Comparative Effectiveness Review Nu
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This report is based on research co
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Acknowledgments The authors gratefu
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Peer Reviewers Prior to publication
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BCI; moderate SOE for effects of pr
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Overview of the Literature ........
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Executive Summary Introduction Infa
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for contextual questions as few eff
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Figure B. Analytic framework for KQ
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Table A. Inclusion criteria (contin
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precision (precise, imprecise), and
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Figure D. Estimates of expected IH
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majority of studies to date have in
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effectiveness outcomes. The evidenc
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changes. We considered the strength
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Table C. Summary of evidence in stu
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Table D. Summary of evidence in stu
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Applicability We set inclusion crit
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quantitative meta-analyses. Researc
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surgically. Lesion characteristics
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References 1. Wassef M, Blei F, Ada
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39. Yu L, Li S, Su B, et al. Treatm
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modalities. The questions of imagin
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KQ2. Among newborns, infants, and c
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of data, and compiling evidence. We
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We only included studies published
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a standardized form (Appendix B) th
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Determining Quality Ratings • We
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Results We present results for Cont
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defects, urogenital anomalies, ulce
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Results of Literature Searches for
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Table 3. Characteristics of include
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scans, had a sensitivity of 20 perc
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of the model fit to all studies, bu
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Detailed Analysis Effectiveness of
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Table 6. Key resolution outcomes in
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with prednisolone included endocrin
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children in 8 studies), skin atroph
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hypopigmentation, impaired wound he
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fair quality for effectiveness outc
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studies of nadolol and atenolol. No
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Table 10. Key resolution outcomes i
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old. 100 Thirty percent of children
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Table 11. Resolution outcomes in st
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Table 15. Key outcomes in studies c
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Table 22. Harms/adverse effects in
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Table 24. Adverse effects in case s
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Table 24. Adverse effects in case s
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• In two RCTs reporting level of
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Nd:YAG Laser With Cooling Compared
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long term follow information was av
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Discussion State of the Literature
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Table 34. Strength of evidence for
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Effectiveness and Harms of Beta-Blo
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older children. One comparative stu
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case series reporting on rarer pres
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agents is critical, especially as u
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References 1. Wassef M, Blei F, Ada
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39. Chen TS, Eichenfield LF, Friedl
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80. Mai HM, Zheng JW, Wang YA, et a
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119. Sharma LK, Dalal SS. Corticost
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162. Snir M, Reich U, Siegel R, et
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198. Chen ZG, Zheng JW, Yuan ML, et
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237. Healy G, McGill T, Friedman EM
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Abbreviations and Acronyms Used in
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Appendix A. Search Strategies Searc
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Searches for Comparative Effectiven
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Appendix B. Screening and Quality A
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Harms Risk of Bias Assessment Form
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QUADAS Diagnostic Accuracy Rating T
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Infantile Hemangioma CER: Risk of B
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20. Grundfest-Broniatowski S, Carey
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65. Dachman AH, Lichtenstein JE, Fr
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111. Yoshida T, Kuratomi K, Mitsuma
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160. Newman SL, Goodwin CD. Colonic
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204. Crockett DM, Healy GB, McGill
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253. Wright GL, Smith RJ, Katz CD,
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301. Paley D, Jackson RW. Synovial
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346. Dombrowski MP, Budev H, Wolfe
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390. Stringel G. Giant hemangioma:
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436. Liu HC, Chang MH, Lue HC, et a
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480. Casale AJ, Menashe DS. Massive
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526. Taylor RS, Joseph DB, Kohaut E
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571. Goldstein MH. The elastic flap
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614. Salloum E, Flamant F, Caillaud
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659. Fellows KE, Hoffer FA, Markowi
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706. Weatherford DA, Abrams RS, Wal
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749. Keleti D, Flickinger JC, Hobso
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793. Van Campenhout I, Patriquin H.
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836. Goldman MP, Fitzpatrick RE, Ru
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880. Schulman SR, Jones BR, Slotnic
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924. Egawa H, Berquist W, Garcia-Ke
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968. Thompson DN, Taylor WF, Haywar
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1013. Gregg CM, Wiatrak BJ, Koopman
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1056. Rozylo TK, Krupski W, Galkows
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1099. Fremont S, Kanny G, Bieber S,
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1142. Sreeram N, Miller P, John P.
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1185. Enjolras O, Wassef M, Mazoyer
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1228. Paley MR, Farrant P, Kane P,
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1271. Burrows PE, Robertson RL, Mul
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1312. Lezama-del Valle P, Gerald WL
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1352. Altunay IK, Gokdemir G, Koken
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1394. Kiristioglu I, Kilic N, Gurpi
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1437. Yoshida D, Sugisaki Y, Shimur
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1480. Kreusel KM, Bechrakis NE, Hei
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1523. Wilken JJ, Meier FA, Kornstei
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1568. Garmendia G, Miranda N, Borro
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1610. Park EA, Seo JW, Lee SW, et a
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1652. Chatrath P, Black M, Jani P,
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1694. Hopf M, Hopf JUG, Rohde E, et
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1737. Rozylo-Kalinowska I, Brodzisz
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1782. Coras B, Hohenleutner U, Land
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1826. McQueen CT, Cullen RD. Endosc
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1866. Tsao MN, Schwartz ML, Bernste
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1909. Denier C, Labauge P, Brunerea
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1950. Mounayer C, Benndorf G, Bisdo
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1992. Woo SJ, Kim CJ, Yu YS. Cavern
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2036. Ersoy S, Mancini AJ. Hemifaci
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2077. Kronenberg A, Blei F, Ceisler
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2117. Sabharwal GK, Strouse PJ. Pos
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2159. Cannady SB, Kahn TA, Trabouls
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2200. Karikari IO, Selznick LA, Cum
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2241. Pienaar C, Graham R, Geldenhu
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2283. Wananukul S, Voramethkul W, N
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2327. Czernik A, Bystryn JC. Does i
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2368. Kamida T, Takeda Y, Fujiki M,
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2410. Rodgers B, Zeim S, Crawford B
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2453. Zolkipli Z, Aylett S, Rankin
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2495. Egberts F, Mentzel T, Leuschn
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2537. Kutluhan A, Bozdemir K, Ugras
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2620. Yun TJ, Na DG, Kwon BJ, et al
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2700. Iriz A, Durmaz E, Akmansu SH,
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2744. Ooi KG, Wenderoth JD, Francis
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2786. Tyzio R, Khalilov I, Represa
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2827. Bayliss SJ, Berk DR, Van Hare
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2869. Fernandez-Pineda I, Lopez-Gut
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2910. Kazim SF, Bhatti, Enam SA. In
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2953. Nonogaki S, Campos HGA, Butug
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2995. Storch CH, Hoeger PH. Propran
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3038. Al Dhaybi R, Superstein R, Mi
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3080. del Pozo J, Lopez-Gutierrez J
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3120. Guye E, Chollet-Rivier M, Sch
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3159. Kolokythas A, Al-Ghamian H, M
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3201. Nale P. Propranolol treatment
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3243. Soltani AM, Reinisch JF. Algo
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3286. . Derm Dx. Clinical Advisor.
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3326. Chang YT, Lin JY, Lee JY, et
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3367. Gross BC, Janus JR, Orvidas L
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3407. Kupeli S. Use of propranolol
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Page 369 and 370: 3969. Ravenscroft J. Management of
Page 371 and 372: where ΦΦ(xx) is the cumulative di
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Page 403 and 404: 120. Pandey A, Gangopadhyay AN, Gop
Page 405 and 406: Appendix G. Applicability Tables Ta
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Page 419 and 420: Harms Data for Medications Included
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Page 431 and 432: Discontinuations Patients utilizing
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Diagnosis and Management of Infantile Hemangioma

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