Diagnosis and Management of Infantile Hemangioma

Results of Literature Searches for Key Questions
We identified 4132 nonduplicative titles or abstracts with potential relevance, with 1273
proceeding to full text review (Figure 4). We excluded 1120 studies at full text review. We
included 148 unique studies (153 publications) in the review. These 148 studies included 42
comparative studies, 38 addressing effectiveness and harms of therapies four assessing
effectiveness only, and 106 case series providing data on harms only. We present findings by
intervention under each Key Question.
Figure 4. Disposition of studies identified for this review
KQ = Key Question; n = number
†Numbers next to each Key Question indicate number of unique studies addressing the question. Studies could address more than
one Key Question. Neither study identified for KQ1 addressed harms. Of the 105 studies identified for KQ2, 28 addressed
benefits and harms, 1 addressed only benefits, and 76 addressed only harms. Of the 41 identified for KQ4, 10 addressed benefits
and harms, one addressed only benefits, and 30 addressed only harms.
* Numbers do not tally as studies could be excluded for multiple reasons.
Description of Included Studies
The 148 unique studies addressing Key Questions comprise 15 randomized controlled trials
(RCTs), five prospective and 19 retrospective cohort studies, two diagnostic accuracy studies
(defined as studies that compared the accuracy of imaging modalities in identifying or
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