Diagnosis and Management of Infantile Hemangioma

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Author, Year Were the harms predefined using standardized or precise definitions? Were all pre-specified harms reported? Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection? Were the statistical methods used to assess the main harm or adverse event outcomes adequate? Rating Thayal 2012 33 Wang 2012 96 Xu 2012 97 Zegpi-Trueba 2012 98 Awadein 2011 34 Bertrand 2011 35 Blatt 2011 99 Chang 2011 100 Cushing 2011 101 Daramola 2011 102 Di Maio 2011 103 Fuchsmann 2011 104 Greene 2011 105 Hermans 2011 36 Partial Unclear Partial Unclear Poor Partial Unclear Partial Yes Poor Yes Yes Yes Yes Good Unclear Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor Unclear Unclear Unclear Yes Poor Yes Yes Yes Unclear Fair No Unclear Unclear Yes Poor Yes Yes Yes No Fair Yes Yes Yes Yes Good No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor F-11
Author, Year Were the harms predefined using standardized or precise definitions? Were all pre-specified harms reported? Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection? Were the statistical methods used to assess the main harm or adverse event outcomes adequate? Rating Hogeling 2011 10 Holmes 2011 106 Kulbersh 2011 107 Li 2011 108 Price 2011 37 Rossler 201130, 31 Saint-Jean 2011 109 Schiestl 2011 110 Schupp 2011 111 Snir 2011 112 Zaher 2011 113 Zvulunov 2011 114 Arneja 2010 115 Hamou 2010 116 Partial Unclear Partial Yes Poor Partial Unclear Partial Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor Partial Unclear Partial Yes Poor Partial Unclear Partial Yes Poor Partial Unclear Partial Yes Poor Partial Unclear Partial Yes Poor Partial Unclear Partial Yes Poor Partial Unclear Partial Unclear Poor No Unclear No Yes Poor No Unclear No Yes Poor No Unclear No Yes Poor F-12
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Comparative Effectiveness Review Nu
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This report is based on research co
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Acknowledgments The authors gratefu
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Peer Reviewers Prior to publication
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BCI; moderate SOE for effects of pr
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Overview of the Literature ........
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Executive Summary Introduction Infa
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for contextual questions as few eff
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Figure B. Analytic framework for KQ
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Table A. Inclusion criteria (contin
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precision (precise, imprecise), and
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Figure D. Estimates of expected IH
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majority of studies to date have in
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effectiveness outcomes. The evidenc
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changes. We considered the strength
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Table C. Summary of evidence in stu
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Table D. Summary of evidence in stu
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Applicability We set inclusion crit
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quantitative meta-analyses. Researc
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surgically. Lesion characteristics
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References 1. Wassef M, Blei F, Ada
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39. Yu L, Li S, Su B, et al. Treatm
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modalities. The questions of imagin
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KQ2. Among newborns, infants, and c
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of data, and compiling evidence. We
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We only included studies published
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a standardized form (Appendix B) th
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Determining Quality Ratings • We
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Results We present results for Cont
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defects, urogenital anomalies, ulce
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Results of Literature Searches for
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Table 3. Characteristics of include
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scans, had a sensitivity of 20 perc
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of the model fit to all studies, bu
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Detailed Analysis Effectiveness of
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Table 6. Key resolution outcomes in
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with prednisolone included endocrin
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children in 8 studies), skin atroph
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hypopigmentation, impaired wound he
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fair quality for effectiveness outc
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studies of nadolol and atenolol. No
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Table 10. Key resolution outcomes i
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old. 100 Thirty percent of children
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Table 11. Resolution outcomes in st
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Table 15. Key outcomes in studies c
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Table 22. Harms/adverse effects in
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Table 24. Adverse effects in case s
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Table 24. Adverse effects in case s
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• In two RCTs reporting level of
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Nd:YAG Laser With Cooling Compared
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long term follow information was av
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Discussion State of the Literature
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Table 34. Strength of evidence for
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Effectiveness and Harms of Beta-Blo
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older children. One comparative stu
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case series reporting on rarer pres
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agents is critical, especially as u
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References 1. Wassef M, Blei F, Ada
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39. Chen TS, Eichenfield LF, Friedl
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80. Mai HM, Zheng JW, Wang YA, et a
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119. Sharma LK, Dalal SS. Corticost
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162. Snir M, Reich U, Siegel R, et
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198. Chen ZG, Zheng JW, Yuan ML, et
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237. Healy G, McGill T, Friedman EM
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Abbreviations and Acronyms Used in
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Appendix A. Search Strategies Searc
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Searches for Comparative Effectiven
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Appendix B. Screening and Quality A
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Harms Risk of Bias Assessment Form
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QUADAS Diagnostic Accuracy Rating T
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Infantile Hemangioma CER: Risk of B
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20. Grundfest-Broniatowski S, Carey
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65. Dachman AH, Lichtenstein JE, Fr
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111. Yoshida T, Kuratomi K, Mitsuma
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160. Newman SL, Goodwin CD. Colonic
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204. Crockett DM, Healy GB, McGill
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253. Wright GL, Smith RJ, Katz CD,
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301. Paley D, Jackson RW. Synovial
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346. Dombrowski MP, Budev H, Wolfe
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390. Stringel G. Giant hemangioma:
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436. Liu HC, Chang MH, Lue HC, et a
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480. Casale AJ, Menashe DS. Massive
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526. Taylor RS, Joseph DB, Kohaut E
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571. Goldstein MH. The elastic flap
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614. Salloum E, Flamant F, Caillaud
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659. Fellows KE, Hoffer FA, Markowi
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706. Weatherford DA, Abrams RS, Wal
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749. Keleti D, Flickinger JC, Hobso
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793. Van Campenhout I, Patriquin H.
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836. Goldman MP, Fitzpatrick RE, Ru
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880. Schulman SR, Jones BR, Slotnic
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924. Egawa H, Berquist W, Garcia-Ke
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968. Thompson DN, Taylor WF, Haywar
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1013. Gregg CM, Wiatrak BJ, Koopman
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1142. Sreeram N, Miller P, John P.
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1185. Enjolras O, Wassef M, Mazoyer
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1782. Coras B, Hohenleutner U, Land
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1826. McQueen CT, Cullen RD. Endosc
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1866. Tsao MN, Schwartz ML, Bernste
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1909. Denier C, Labauge P, Brunerea
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1950. Mounayer C, Benndorf G, Bisdo
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1992. Woo SJ, Kim CJ, Yu YS. Cavern
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2036. Ersoy S, Mancini AJ. Hemifaci
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2117. Sabharwal GK, Strouse PJ. Pos
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2159. Cannady SB, Kahn TA, Trabouls
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2327. Czernik A, Bystryn JC. Does i
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2786. Tyzio R, Khalilov I, Represa
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2869. Fernandez-Pineda I, Lopez-Gut
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2910. Kazim SF, Bhatti, Enam SA. In
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2953. Nonogaki S, Campos HGA, Butug
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2995. Storch CH, Hoeger PH. Propran
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3038. Al Dhaybi R, Superstein R, Mi
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3080. del Pozo J, Lopez-Gutierrez J
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3120. Guye E, Chollet-Rivier M, Sch
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3159. Kolokythas A, Al-Ghamian H, M
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3201. Nale P. Propranolol treatment
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3243. Soltani AM, Reinisch JF. Algo
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3286. . Derm Dx. Clinical Advisor.
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3326. Chang YT, Lin JY, Lee JY, et
Page 339 and 340: 3367. Gross BC, Janus JR, Orvidas L
Page 341 and 342: 3407. Kupeli S. Use of propranolol
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Page 345 and 346: 3490. Traivaree C, Lumkul R, Torcha
Page 347 and 348: 3532. Ammerman RT, Putnam FW, Altay
Page 349 and 350: 3573. Chou S, Subramanian V, Lau HM
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Page 359 and 360: 3772. Zou HX, Jia J, Zhang WF, et a
Page 361 and 362: 3813. Deng X, Wang K, Wu L, et al.
Page 363 and 364: 3851. Khorsand K, Backus S, Sidbury
Page 365 and 366: 3890. Phillips RJ, Lokmic Z, Crock
Page 367 and 368: 3930. Weil AG, Bhatia S. Resection
Page 369 and 370: 3969. Ravenscroft J. Management of
Page 371 and 372: where ΦΦ(xx) is the cumulative di
Page 373 and 374: Figure D-1. Estimates of expected I
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Page 379 and 380: Appendix E. Study Design Classifica
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Page 397 and 398: 25. Qiu Y, Ma G, Yang J, et al. Imi
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Page 403 and 404: 120. Pandey A, Gangopadhyay AN, Gop
Page 405 and 406: Appendix G. Applicability Tables Ta
Page 407 and 408: Appendix H. Harms Reported in Packa
Page 409 and 410: o Acquired (autoimmune) hemolytic a
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Page 415 and 416: Elocon® (mometason e furoate) 11 T
Page 417 and 418: Timoptic® (timolol maleate) 15 Tim
Page 419 and 420: Harms Data for Medications Included
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Page 425 and 426: thromboembolism, thrombophlebitis,
Page 427 and 428: grades): 103 (48%), erosion/ulcerat
Page 429 and 430: acute myocardial infarction: 3 (Rat
Page 431 and 432: Discontinuations Patients utilizing
Page 433 and 434: ocular irritation including blephar
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Diagnosis and Management of Infantile Hemangioma

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