Diagnosis and Management of Infantile Hemangioma

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Author, Year Were the harms predefined using standardized or precise definitions? Were all pre-specified harms reported? Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection? Were the statistical methods used to assess the main harm or adverse event outcomes adequate? Rating Li 2010 117 Manunza 2010 118 Pandey 2010 11 Chen 2009 119 Pandey 2009 120 Rizzo 2009 121 Saleh 2009 122 Sans 2009 123 Wu 2009 124 No Unclear Unclear No Poor Partial Unclear Partial Unclear Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear No Yes Poor No Unclear No No Poor Partial Unclear Partial Yes Poor No Unclear No Yes Poor Chantharatanapiboon 2008 125 No Unclear Unclear Yes Poor Chen 2008 126 Claude 2008 127 Baraldini 2007 128 Pope 2007 12 No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor Yes Yes Yes Yes Good F-13
Author, Year Were the harms predefined using standardized or precise definitions? Were all pre-specified harms reported? Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection? Were the statistical methods used to assess the main harm or adverse event outcomes adequate? Rating Jalil 2006 13 Kono 2006 14 Garzon 2005 129 McHeik 2005 130 Nicolai 2005 38 Waldschmidt 2005 131 Vlachakis 2004 39 David 2003 132 Vlachakis 2003 133 Batta 2002 15 Akyuz 2001 40 Chang 2001 41 Demiri 2001 134 Hohenleutner 2001 135 Yes Yes Yes Yes Good Unclear Unclear Unclear Yes Poor No Unclear No No Poor No Unclear No Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Yes Poor No Unclear Unclear Unclear Poor No Unclear Unclear Unclear Poor No Unclear No Yes Poor Yes Yes Yes Yes Good No Unclear Unclear Unclear Poor No Unclear Unclear Unclear Poor No Unclear Unclear Yes Poor Unclear Unclear Unclear No Poor F-14
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Comparative Effectiveness Review Nu
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This report is based on research co
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Acknowledgments The authors gratefu
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Peer Reviewers Prior to publication
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BCI; moderate SOE for effects of pr
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Overview of the Literature ........
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Executive Summary Introduction Infa
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for contextual questions as few eff
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Figure B. Analytic framework for KQ
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Table A. Inclusion criteria (contin
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precision (precise, imprecise), and
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Figure D. Estimates of expected IH
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majority of studies to date have in
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effectiveness outcomes. The evidenc
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changes. We considered the strength
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Table C. Summary of evidence in stu
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Table D. Summary of evidence in stu
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Applicability We set inclusion crit
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quantitative meta-analyses. Researc
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surgically. Lesion characteristics
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References 1. Wassef M, Blei F, Ada
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39. Yu L, Li S, Su B, et al. Treatm
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modalities. The questions of imagin
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KQ2. Among newborns, infants, and c
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of data, and compiling evidence. We
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We only included studies published
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a standardized form (Appendix B) th
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Determining Quality Ratings • We
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Results We present results for Cont
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defects, urogenital anomalies, ulce
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Results of Literature Searches for
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Table 3. Characteristics of include
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scans, had a sensitivity of 20 perc
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of the model fit to all studies, bu
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Detailed Analysis Effectiveness of
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Table 6. Key resolution outcomes in
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with prednisolone included endocrin
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children in 8 studies), skin atroph
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hypopigmentation, impaired wound he
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fair quality for effectiveness outc
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studies of nadolol and atenolol. No
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Table 10. Key resolution outcomes i
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old. 100 Thirty percent of children
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Table 11. Resolution outcomes in st
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Table 15. Key outcomes in studies c
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Table 22. Harms/adverse effects in
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Table 24. Adverse effects in case s
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Table 24. Adverse effects in case s
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• In two RCTs reporting level of
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Nd:YAG Laser With Cooling Compared
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long term follow information was av
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Discussion State of the Literature
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Table 34. Strength of evidence for
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Effectiveness and Harms of Beta-Blo
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older children. One comparative stu
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case series reporting on rarer pres
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agents is critical, especially as u
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References 1. Wassef M, Blei F, Ada
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39. Chen TS, Eichenfield LF, Friedl
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80. Mai HM, Zheng JW, Wang YA, et a
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119. Sharma LK, Dalal SS. Corticost
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162. Snir M, Reich U, Siegel R, et
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198. Chen ZG, Zheng JW, Yuan ML, et
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237. Healy G, McGill T, Friedman EM
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Abbreviations and Acronyms Used in
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Appendix A. Search Strategies Searc
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Searches for Comparative Effectiven
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Appendix B. Screening and Quality A
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Harms Risk of Bias Assessment Form
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QUADAS Diagnostic Accuracy Rating T
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Infantile Hemangioma CER: Risk of B
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20. Grundfest-Broniatowski S, Carey
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65. Dachman AH, Lichtenstein JE, Fr
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111. Yoshida T, Kuratomi K, Mitsuma
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160. Newman SL, Goodwin CD. Colonic
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204. Crockett DM, Healy GB, McGill
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253. Wright GL, Smith RJ, Katz CD,
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301. Paley D, Jackson RW. Synovial
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346. Dombrowski MP, Budev H, Wolfe
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390. Stringel G. Giant hemangioma:
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436. Liu HC, Chang MH, Lue HC, et a
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480. Casale AJ, Menashe DS. Massive
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526. Taylor RS, Joseph DB, Kohaut E
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571. Goldstein MH. The elastic flap
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614. Salloum E, Flamant F, Caillaud
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659. Fellows KE, Hoffer FA, Markowi
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706. Weatherford DA, Abrams RS, Wal
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749. Keleti D, Flickinger JC, Hobso
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793. Van Campenhout I, Patriquin H.
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836. Goldman MP, Fitzpatrick RE, Ru
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880. Schulman SR, Jones BR, Slotnic
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924. Egawa H, Berquist W, Garcia-Ke
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968. Thompson DN, Taylor WF, Haywar
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1013. Gregg CM, Wiatrak BJ, Koopman
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1056. Rozylo TK, Krupski W, Galkows
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1099. Fremont S, Kanny G, Bieber S,
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1142. Sreeram N, Miller P, John P.
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1185. Enjolras O, Wassef M, Mazoyer
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1228. Paley MR, Farrant P, Kane P,
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1312. Lezama-del Valle P, Gerald WL
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1437. Yoshida D, Sugisaki Y, Shimur
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1480. Kreusel KM, Bechrakis NE, Hei
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1523. Wilken JJ, Meier FA, Kornstei
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1568. Garmendia G, Miranda N, Borro
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1610. Park EA, Seo JW, Lee SW, et a
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1652. Chatrath P, Black M, Jani P,
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1694. Hopf M, Hopf JUG, Rohde E, et
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1737. Rozylo-Kalinowska I, Brodzisz
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1782. Coras B, Hohenleutner U, Land
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1826. McQueen CT, Cullen RD. Endosc
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1866. Tsao MN, Schwartz ML, Bernste
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1909. Denier C, Labauge P, Brunerea
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1950. Mounayer C, Benndorf G, Bisdo
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1992. Woo SJ, Kim CJ, Yu YS. Cavern
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2036. Ersoy S, Mancini AJ. Hemifaci
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2077. Kronenberg A, Blei F, Ceisler
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2117. Sabharwal GK, Strouse PJ. Pos
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2159. Cannady SB, Kahn TA, Trabouls
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2200. Karikari IO, Selznick LA, Cum
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2241. Pienaar C, Graham R, Geldenhu
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2283. Wananukul S, Voramethkul W, N
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2327. Czernik A, Bystryn JC. Does i
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2368. Kamida T, Takeda Y, Fujiki M,
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2410. Rodgers B, Zeim S, Crawford B
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2453. Zolkipli Z, Aylett S, Rankin
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2495. Egberts F, Mentzel T, Leuschn
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2744. Ooi KG, Wenderoth JD, Francis
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2786. Tyzio R, Khalilov I, Represa
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2869. Fernandez-Pineda I, Lopez-Gut
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2910. Kazim SF, Bhatti, Enam SA. In
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2953. Nonogaki S, Campos HGA, Butug
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2995. Storch CH, Hoeger PH. Propran
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3038. Al Dhaybi R, Superstein R, Mi
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3080. del Pozo J, Lopez-Gutierrez J
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3120. Guye E, Chollet-Rivier M, Sch
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3159. Kolokythas A, Al-Ghamian H, M
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3201. Nale P. Propranolol treatment
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3243. Soltani AM, Reinisch JF. Algo
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3286. . Derm Dx. Clinical Advisor.
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3326. Chang YT, Lin JY, Lee JY, et
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3367. Gross BC, Janus JR, Orvidas L
Page 341 and 342: 3407. Kupeli S. Use of propranolol
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Page 345 and 346: 3490. Traivaree C, Lumkul R, Torcha
Page 347 and 348: 3532. Ammerman RT, Putnam FW, Altay
Page 349 and 350: 3573. Chou S, Subramanian V, Lau HM
Page 351 and 352: 3614. Hyland RM, Komlosi K, Alleman
Page 353 and 354: 3655. Masetti R, Colecchia A, Ronde
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Page 357 and 358: 3732. Stiles JM, Amaya C, Rains S,
Page 359 and 360: 3772. Zou HX, Jia J, Zhang WF, et a
Page 361 and 362: 3813. Deng X, Wang K, Wu L, et al.
Page 363 and 364: 3851. Khorsand K, Backus S, Sidbury
Page 365 and 366: 3890. Phillips RJ, Lokmic Z, Crock
Page 367 and 368: 3930. Weil AG, Bhatia S. Resection
Page 369 and 370: 3969. Ravenscroft J. Management of
Page 371 and 372: where ΦΦ(xx) is the cumulative di
Page 373 and 374: Figure D-1. Estimates of expected I
Page 375 and 376: Figure D-3. Posterior SUCRA estimat
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Page 379 and 380: Appendix E. Study Design Classifica
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Page 397 and 398: 25. Qiu Y, Ma G, Yang J, et al. Imi
Page 399 and 400: 56. Hassan BA, Shreef KS. Propranol
Page 401 and 402: 88. Chakkittakandiyil A, Phillips R
Page 403 and 404: 120. Pandey A, Gangopadhyay AN, Gop
Page 405 and 406: Appendix G. Applicability Tables Ta
Page 407 and 408: Appendix H. Harms Reported in Packa
Page 409 and 410: o Acquired (autoimmune) hemolytic a
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Page 413 and 414: H-7 • Increased dosage of rapidly
Page 415 and 416: Elocon® (mometason e furoate) 11 T
Page 417 and 418: Timoptic® (timolol maleate) 15 Tim
Page 419 and 420: Harms Data for Medications Included
Page 421 and 422: Table H-3: Adverse Events from Flo-
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Page 425 and 426: thromboembolism, thrombophlebitis,
Page 427 and 428: grades): 103 (48%), erosion/ulcerat
Page 429 and 430: acute myocardial infarction: 3 (Rat
Page 431 and 432: Discontinuations Patients utilizing
Page 433 and 434: ocular irritation including blephar
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Diagnosis and Management of Infantile Hemangioma

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