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No. 64 (PM 13)
Measurement of Procalcitonin (PCT) and C-Reactive Protein (CRP) in Patients with
ESBL-negative Bacteremia
Soohun Yoo 1 , Seri Jeong 1 , Yongjung Park 1 , Nam Su Ku 2 , Dongeun Yong 1 and Hyon-Suk Kim 1*
1 Department of Laboratory Medicine and 2 Internal Medicine, Severance Hospital, Yonsei University
College of Medicine, Seoul, South Korea
Aim: We measured procalcitonin (PCT) and C-reactive protein (CRP) in patients with extended
spectrum beta lactamase (ESBL)-negative bacteremia and analyzed the results according to clinical
status of the patients. Materials and Methods: A total of 100 patients who were ESBL-negative
bacteremia were analyzed. Among measured database, data from first and last tests of PCT (PCT1,
PCT2) and CRP (CRP1, CRP2) during hospital stay were evaluated. PCT levels were measured by the
VIDAS ® BRAHMS PCT assay, and CRP concentrations were determined by a turbidimetric assay using
CA-400 analyzer. Results: The levels PCT1 of patients with community acquired infection (n=65) were
more significantly higher than those with nosocomial infection (n=35) (12.6 ng/mL vs. 1.5 ng/mL,
p=0.0001). Clinically, PCT1 levels were significantly higher in patients with central line insertion
(p=0.0089), pneumonia (p=0.0233) and intensive care unit admission (p=0.0258) than in patients
without these conditions. CRP2 levels were significantly higher in patients with intubation (p=0.0064),
leukocytosis at the admission (p=0.0081) and urinary tract infection (UTI) (p=0.0198). The higher
levels of PCT2 were shown in patients with mortality (p=0.0005) and UTI (p=0.0198). Similarly,
CRPs2 were also relevant with mortality (p