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FO 6
The Analysis on the familial tendency of Transferrin Saturation (TS) in Korean
Families Based on The Fifth Korea National Health and Nutrition Examination
Survey (KNHNES, V-1) 2010
Sung-Hee Oh, So-Young Kim, Woochang Lee, Sail Chun, and Won-Ki Min*
Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine,
Korea
Background TS is an index used to screen hereditary hemochromatosis (HH), a disease characterized
by the deposition of excessive amounts of iron in parenchymal cells. Despite very low incidences of
C282Y and H63D mutations, well-known common genetic causes of HH, some studies showed higher
TS level in Koreans compared with those of Caucasians. This study aims to compare TS level between
Korean population and the U.S. Caucasian by using the data of KNHANES V-1 and National Health and
Nutrition Examination Survey (NHANES), 2001-2002. In addition, we tried to assess the existence of a
familial tendency in Korean’s TS level by statistical analysis of parents’ and children’s TS value.
Methods Among 8958 KNHANES V-1 subjects, those without anemia and hepatitis B antigen were
enrolled in this study. The age distribution of 2946 males was 10-91 years old (mean±SD, 43.3±19.3)
and 10-93 years old for 3243 females (44.6±18.6). 557 families with at least one child were included for
an analysis for familial tendency and total number of subjects within them was 1907.Each parent was
grouped into four quartiles (designated as 1, 2, 3 and 4) based on his or her TS levels and then the mean
of paternal and maternal TS four quartile indices (MTQI) were calculated and used for further analysis.
Their offspring’s mean TS levels (OMTL) among each MTQI group were compared using one-way
analysis of variance and post-hoc multiple comparison to show the statistical differences. NHANES
2001-2002 was used to evaluate the mean TS level in Caucasian and unpaired student t-test was
performed to assess the statistical difference. We considered a p-value