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No. 21 (PC 21) Lipid Peroxidation and Selected Non-Enzymatic Antioxidants in Sickle Cell Disease Patients in South West, Nigeria Adesina Adeyemi Adeleke; Oyedeji Samuel; Oladepo Ridwan; Oke Taiwo; Fasakin Kolawole Department of Chemical Pathology, OAUTHC, Ife, PMB5538, Osun-State, Nigeria Department of Heamatology and Blood Transfusion, OAUTHC, Ife, Osun-State, Nigeria Objective: Sickle cell anaemia (SCA) is hereditary disorder with higher potential for oxidative damage due to chronic redox imbalance in red cells and vaso-occlusive crisis. Methods: Levels of lipid peroxidation and vitamins antioxidant status were determine in fifty (50) sickle cell anaemia patients in Osun State, Nigeria. Thirty (30) normal heamoglobin individual were used as controls. Malondialdehyde (MDA), Vitamin C, vitamin E, Lipid profile were estimated in patients and control serum using standard spectrophotometric analysis. Results: The results showed significant increase in MDA of patients compared with control 0.94± 0.2 and 0.49±4µmol/l, P
No. 22 (PE 1) Two-Step Biochemical Differential Diagnosis of Classic 21-hydroxylase Deficiency and Cytochrome P450 Oxidoreductase Deficiency in Japanese Infants Using Urinary Steroid Metabolites by Gas Chromatography - Mass Spectrometry Yuhei Koyama 1)2) , Keiko Homma 3) , Maki Fukami 4) , Masayuki Miwa 5) , Kazushige Ikeda 5) , Tsutomu Ogata 4) , Tomonobu Hasegawa 5) , Mitsuru Murata 1) 1) Department of Laboratory Medicine, Keio University School of Medicine, 2) Mitsubishi Chemical Medience Co., 3) Central Clinical Laboratories, Keio University Hospital, 4) Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, 5) Department of Pediatrics, Keio University School of Medicine, Japan [Introduction] The clinical differential diagnosis of classic 21-hydroxylase deficiency (C21OHD) and cytochrome P450 oxidoreductase deficiency (PORD) is sometimes difficult since both deficiencies can have similar phenotypes and high blood concentrations of 17α-hydroxyprogesterone (17OHP). The objective of this study was to explore novel biochemical indexes for the differential diagnosis of C21OHD, PORD, and transient hyper 17α-hydroxyprogesteronemia (TH17OHP) in Japanese newborns. [Material and Methods] We recruited 29 infants with C21OHD, 9 infants with PORD, 67 infants with TH17OHP, and 1341 control infants. All infants were Japanese between 0-180 days old. None received glucocorticoid treatment before urine sampling. We measured urinary pregnanetriolone (Ptl), the cortisol metabolites 5α- and 5β-tetrahydrocortisone (sum of these metabolites defined THEs), and metabolites of three steroids, namely dehydroepiandrosterone, androstenedione (AD4) and 11β-hydroxyandrostenedione (11OHAD4) by gas chromatography-mass spectrometry. [Results] By using a cutoff 0.020, the ratio of Ptl to THEs, we were able to differentiate C21OHD and PORD from TH17OHP and controls with no overlap (minimum – maximum: 0.14-15, 0.051-0.23, 0.00010-0.011, and 0.000068-0.0083, respectively). Among metabolites of DHEA, AD4, and 11OHAD4, only 11β-hydroxyandrosterone (11HA), a metabolite of 11OHAD4, showed no overlap between C21OHD and PORD (0.61-24 and 0.022-0.22 mg/g creatinine, respectively) using a cutoff of 0.35. [Conclusion] We successfully established a 2-step biochemical differential diagnosis for C21OHD and PORD by urinary steroid metabolites such as Ptl, THEs, and 11HA. - 75 -
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Program / Abstract Book
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Welcome Dear Friends and Colleagues
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ASCPaLM 2012 Executive Committee Pr
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Sponsors and supporters Abbott Japa
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Approximate Flight Times to Japan F
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The Kyoto City Subway system is eas
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Scientific Program Information Spea
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Event Hall is located by the confer
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Keynote Lecture (Chaired by Mitsuru
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FO 1 CLINICAL PATHOLOGY SCOPE IN CA
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FO 3 SUSTAINED EXPRESSION OF A NEUR
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FO 5 INDIAN STUDY OF LIVER FUNCTION
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Advanced Technical Seminar Sekisui
Page 27 and 28: Measurement of Albuminuria (Siemens
Page 29 and 30: The current status of the diagnosis
Page 31 and 32: Establishment of Reference Interval
Page 33 and 34: Innovative Lipid Biomarkers (Denka
Page 35 and 36: Scientific Innovation Seminar (Abbo
Page 37 and 38: PLEX-ID Technology as a Single Tool
Page 39 and 40: POSTER SESSION 1. Clinical Chemistr
Page 41 and 42: Naoko Yamaguchi, Tomohiro Takeda, C
Page 43 and 44: in Type 2 Diabetes Mellitus First D
Page 45 and 46: No. 36. Identification of autoantib
Page 47 and 48: Okamura 1) , Masahumi Takata 2) , M
Page 49 and 50: Hunsuk Suh 1 MD, PhD, Jonghee Shin
Page 51 and 52: Department of Pathology, Kansai Med
Page 53 and 54: No. 80. Introduction of HCV Quantif
Page 55 and 56: No. 91. Genome-wide association ana
Page 57 and 58: Abstracts - 53 -
Page 59 and 60: No. 2 (PC2) Soluble FcγRIIIa Mφ l
Page 61 and 62: No. 4 (PC 4) Detection of hereditar
Page 63 and 64: No. 6 (PC 6) Analysis of cholestery
Page 65 and 66: No. 8 (PC 8) Development of the enz
Page 67 and 68: No. 10 (PC 10) Direct analysis of c
Page 69 and 70: No. 12 (PC 12) Reference value for
Page 71 and 72: No. 14 (PC 14) Detection of autoant
Page 73 and 74: No. 16 (PC 16) Temporal changes in
Page 75 and 76: No. 18 (PC 18) IODINE STATUS AMONG
Page 77: No. 20 (PC 20) Plasma free Fatty Ac
Page 81 and 82: No. 24 (PE 3) Adiponectin HMW Level
Page 83 and 84: No. 26 (PE 5) Analysis of von Wille
Page 85 and 86: No. 28 (PI 2) Diagnostic value of A
Page 87 and 88: No. 30 (PI 4) Evaluation of Hepatri
Page 89 and 90: No. 32 (PI 6) Discrepancy between s
Page 91 and 92: No. 34 (PI 8) Inhibition of the NF-
Page 93 and 94: No. 36 (PH 2) Identification of aut
Page 95 and 96: No. 38 (PH 4) Contribution of uncon
Page 97 and 98: No. 40 (PH 6) Red Blood Cells absor
Page 99 and 100: No. 42 (PH 8) Great impact of the b
Page 101 and 102: No. 44 (PH 10) Relation between VKO
Page 103 and 104: No. 46 (PH 12) Suspect of malaria i
Page 105 and 106: No. 48 (PH 14) Intravascular large
Page 107 and 108: No. 50 (PH 16) Calculation of Measu
Page 109 and 110: No. 52 (PM 1) High seroprevalence o
Page 111 and 112: No. 54 (PM 3) Epidemiological and m
Page 113 and 114: No. 56 (PM 5) Tuberculosis screenin
Page 115 and 116: No. 58 (PM 7) Mycobacterium Kyorine
Page 117 and 118: No. 60 (PM 9) Sensitive, one, two-d
Page 119 and 120: No. 62 (PM 11) Simultaneous inhibit
Page 121 and 122: No. 64 (PM 13) Measurement of Proca
Page 123 and 124: No. 66 (PF 1) Comparison of four po
Page 125 and 126: No. 68 (PP 1) The expressions of O
Page 127 and 128: No. 70 (PP 3) Poorly differentiated
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No. 72 (PP 5) The morphological cha
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No. 74 (PP 7) Neuropathological fin
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No. 76 (PMB 2) Diagnostic strategie
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No. 78 (PMB 4) Study of essential o
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No. 80 (PMB 6) Introduction of HCV
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No. 82 (PMB 8) Analysis of Fas exon
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No. 84 (PMB 10) A rapid and automat
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No. 86 (PMB 12) Increased expressio
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No 88 (PO 2) Assessment of early ma
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No. 90 (PO 4) The role of Rb2/p130
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No. 92 (PO 6) Molecular analysis of
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No. 94 (PO 8) The genealogical stud
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No. 96 (P0 10) Regulatory and pro-i
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No. 98 (PO 12) Chaotic Nature of My
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[Memo] - 153 -
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