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FO 6 The Analysis on the familial tendency of Transferrin Saturation (TS) in Korean Families Based on The Fifth Korea National Health and Nutrition Examination Survey (KNHNES, V-1) 2010 Sung-Hee Oh, So-Young Kim, Woochang Lee, Sail Chun, and Won-Ki Min* Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine, Korea Background TS is an index used to screen hereditary hemochromatosis (HH), a disease characterized by the deposition of excessive amounts of iron in parenchymal cells. Despite very low incidences of C282Y and H63D mutations, well-known common genetic causes of HH, some studies showed higher TS level in Koreans compared with those of Caucasians. This study aims to compare TS level between Korean population and the U.S. Caucasian by using the data of KNHANES V-1 and National Health and Nutrition Examination Survey (NHANES), 2001-2002. In addition, we tried to assess the existence of a familial tendency in Korean’s TS level by statistical analysis of parents’ and children’s TS value. Methods Among 8958 KNHANES V-1 subjects, those without anemia and hepatitis B antigen were enrolled in this study. The age distribution of 2946 males was 10-91 years old (mean±SD, 43.3±19.3) and 10-93 years old for 3243 females (44.6±18.6). 557 families with at least one child were included for an analysis for familial tendency and total number of subjects within them was 1907.Each parent was grouped into four quartiles (designated as 1, 2, 3 and 4) based on his or her TS levels and then the mean of paternal and maternal TS four quartile indices (MTQI) were calculated and used for further analysis. Their offspring’s mean TS levels (OMTL) among each MTQI group were compared using one-way analysis of variance and post-hoc multiple comparison to show the statistical differences. NHANES 2001-2002 was used to evaluate the mean TS level in Caucasian and unpaired student t-test was performed to assess the statistical difference. We considered a p-value
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