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No. 25 (PE 4)
Age-related Anti-Müllerian hormone Concentrations in Healthy Korean Females
Lee, A 1 ; Jang, TG 2 ; Lim, SY 2 ; Park, JC 2 ; Rhee, JH 2 ;Kim, YJ 1 ; Lee, KY 1
Seoul Medical Science Institute/Seoul Clinical Laboratories, Seoul, Korea 1 , Department of Obstetrics
and Gynecology, School of Medicine, Keimyung University, Daegu, Korea 2
Backgrounds : Currently, serum anti-Müllerian hormone (AMH) in women has been increasingly used
for ovarian reserve function assessment in fertility centers. Here we evaluated age-related AMH values
in various ages of healthy females in Korea, and investigated the relationships with antral follicle count
(AFC) and other fertility hormones.
Methods: We recruited 222 healthy females without specific infertility history in various ages. For
women of reproductive age, blood samples were drawn at day 3 from the onset of cycle. AMH was
measured by ELISA (Immunotech SAS, France). E2, FSH and LH were measured by
chemiluminescence immunoassay (ADVIA Centaur ® XP, Siemens, USA). Statistical analysis was
performed using MedCalc software (version 12.3, Belgium). AMH values were calculated in different
age groups, and correlation of AMH and other hormones were analyzed. For 104 patients whose AFC
assessment was available, correlations of AFC and each hormone were also analyzed.
Results: 2.5 - 97.5 percentiles of AMH values depending age groups are as follows: 0.10 - 3.99 ng/mL
(60 years, n=43). AMH negatively correlated with FSH (r =
-0.4213, P < 0.0001), LH (r = -0.3858, P < 0.0001) and E2 (r = -0.2070, P = 0.0025). Regarding the
relationship of each hormone with AFC, AMH positively correlated with AFC (r = 0.7375, P < 0.0001),
while negatively correlated FSH (r = -0.5401, P < 0.0001).
Conclusion: AMH values should be interpreted in caution, with regard to women’s age, because AMH
values are steadily increased from birth until 20 th , and continuously decreased after 30 th . AMH best
correlates with AFC, which suggest AMH is one of the most promising markers for assessment of
ovarian reserve function.
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