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No. 26 (PE 5)
Analysis of von Willebrand Factors’ Level in Type 2 Diabetes Mellitus
Mansyur Arif 1 , Ichwan Meinardi 1 , Uleng Bahrun 1 , Harsinen Sanusi 2
1 2
Department of Clinical Pathology, Department of Internal Medicine,
Faculty of Medicine Hasanuddin University, Makassar, Indonesia
The aim of this study was to analyze von Willebrand Factor (vWF) level as the risk factor of thrombosis
in type 2 diabetes mellitus. A cross sectional study had been done at Endocrine Metabolic Subdivision
Department of Internal Medicine of Wahidin Sudirohusodo Hospital. Laboratory examination had been
done at Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital Makassar. Seventy-five
participants consisted of 52 subjects with type 2 DM and 25 normal subjects as controls had been
examined. The results of this study showed that the age of type 2 DM subjects were ranging from 39-74
years old and the age of normal controls were ranging from 30-44 years old. The level of vWF in type 2
DM and normal controls were 86-362% and 41-210%, respectively. There was significantly increased of
vWF level in type 2 DM. It was proven that in subject with type 2 DM occurred hypercoagulation states
that characterized by elevated level of vWF. The level of vWF is suggested to be a marker of
hypercoagulation states caused by endothelial dysfunction in type 2 DM. Further study is suggested to
determine the level of vWF in type 2 DM by including other risk factors such as hypertension,
dyslipidemia, smoking and obesity.
Key words: Type 2 Diabetes mellitus, von willebrand factor
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