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No. 42 (PH 8)
Great impact of the brand-new Sysmex XN-Series automated hematology analyzer
on workflow efficiency and utility
Etsuko Hamada, Masato Maekawa
Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
Introduction:
Recently, higher-quality testing environment has been increasingly required. To counteract these
demands, Sysmex has introduced the XN-Series automated hematology analyzer. Here we report our
evaluation results of the XN-Series basic performance and the integrated hematology testing system.
Method: (1) Basic performance: We evaluated precision, linearity, correlation with a previous analyzer
(XE-2100, Sysmex) and correlation with the manual method. (2) Usability: We evaluated the usability
of newly introduced functions of CNA-NET, which include automated smear preparation, selection of
specific sample and sample requiring manual count. Results: (1) Basic performance: Precision (CBC)
was 0.42-5.21 (CV%), and linearity was confirmed up to WBC 378×10 9 /L, RBC 7.81×10 12 /L, HGB 235
g/L, HCT 72.1%, and PLT 1,691×10 9 /L. The correlation coefficients (r) with the previous analyzer
were CBC 0.998–0.981, WBC classification ratio 0.995-0.917 and reticulocyte ratio 0.978. The
correlation coefficient of WBC classification ratio with the manual method was 0.612-0.987. In the
evaluation using samples with WBC ≤ 0.5×10 9 /L, WBC precision was 7.75-8.21 (CV%) for Whole
blood mode and 1.29-4.17 for Low WBC mode, and the good correlation with the manual method was
observed. In the evaluation using samples with PLT ≤ 50×10 9 /L, the correlation coefficient between
PLT-I (impedance) and PLT-F (fluorescence) was 0.973, and with the manual method was 0.975 for
PLT-I and 0.980 for PLT-F. (2) Usability: The number of analyzer operator to measure 700 samples/
day decreased from 1.5 to 1 person. Conclusion: Basic performance of the XN-Series was satisfactory.
Especially, precision and accuracy in the low number of WBC and PLT were excellent. Therefore it is
possible to report higher clinical value result with the automatic measurement method. Use of the
automated re-testing function and the CNA-NET made reporting time and processing time reduced. The
newly introduced integrated hematology testing system improved the quality of the clinical testing.
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