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No. 3 (PC 3)
The Role of S100B Protein and GFAP in Predicting Discharged NIHSS of Anterior
Circulation Ischemic Stroke
Yenny Surjawan, Suryani As’ad, Teguh A.S Ranakusuma, Andi Wijaya
Medical Faculty of Hasanuddin University, INDONESIA
Background: Patient with larger ischemic lesion will suffer more severe neurological deficit. Lesion
size measurement by MRI is still limited. Another approach pursued through examination of markers
released by damaged brain cell. S100B protein and GFAP, markers of damaged brain cell, had been
reported to have an association with stroke. This study aimed to know whether both markers could
estimate the discharged NIHSS of anterior circulation ischemic stroke.
Methods: This observational prospective study was performed on 74 anterior circulation ischemic
stroke patients. S100B protein and GFAP were measured by ELISA.
Results: A significant difference was found in S100B protein concentration between mild and not mild
discharged NIHSS (p < 0.05). S100B protein concentration showed a significant correlation with
discharged NIHSS (r = 0.488; p = 0.000). An equation was yield to predict the risk and probability to get
a not mild discharged NIHSS by S100B protein (OR = 1.009; 95 % CI 1.0003 - 1.0188; p = 0.044).
S100B protein at 78.3215 ng/l produced a 66 % sensitivity and 70 % specificity, with positive and
negative predictive value of 76 % and 58 %, respectively (AUC = 73.9 %, p = 0.001, 95 % CI: 62.7 % –
85.2 %). There was a significant difference in the proportion of subjects with low and high GFAP in
either not severe or severe group of NIHSS at discharge (p = 0.008).
Conclusion: S100B protein measured at 48 to 72 hours after onset could predict the risk and probability
to get a not mild discharged NIHSS in anterior circulation ischemic stroke patients. No subject with low
GFAP level showed a severe NIHSS at discharge.
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