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No. 24 (PE 3)
Adiponectin HMW Level and Homeostasis Model Assessment-Insulin Resistance
(HOMA-IR) in Type 2 Diabetes Mellitus First Degree Relatives
Yulia Sari, Marzuki Suryaatmadja, Budiman Darmowidjojo
Department of Clinical Pathology, Medical Faculty, Universitas Indonesia
Type 2 diabetes mellitus (t2DM) accompanied by macro and microangiopathy complications had
been a serious global problem, with an increasing morbidity and mortality rates.
The most important pathogenesis is insulin resistance (IR), which could be predicted by the
Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Adiponectin has been
already known to increase the insulin sensitivity and play role in balancing the
glucose metabolism. It is very important to be able to detect the prediabetes early to prevent the
complications.. The aim of this study is to get the picture of adiponectin HMW level and the HOMA-IR
as IR predictors in the t2DM first degree relatives, and the correlation between adiponectin level with
fasting insulin and HOMA-IR. This cross-sectional designed study was conducted from April 2011 until
January 2012, on t2DM first degree relatives. The subjects consisted of 52 prediabetes and 52
normoglycaemic respondents. The result revealed that in prediabetic group, the adiponectin HMW
levels in both men and women were significantly lower (P=0,003), HOMA-IR were significantly higher
than in the normoglycaemic group (P=0,0026), and there were negative correlations
between adiponectin HMW level in both men and women with HOMA-IR and fasting
insulin. These findings had proven that IR had been presented in prediabetes stage which was correlate
well to the hypoadiponectinemia. Based on these results, it is recommended to measure adiponectin
HMW, insulin and HOMA-IR in t2DM first degree relatives to detect the IR and to prevent the sickness
earlier to decrease the morbidity and mortality rates.
Keywords: Type 2 Diabetes Mellitus, first degree relatives, prediabetes, insulin resistance,
HOMA-IR, adiponectin HMW
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