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No. 68 (PP 1)
The expressions of O 6 -methylguanine DNA methyltransferase and epidermal
growth factor receptor on ganglioglioma: A clinicopathologic and
immunohistochemical study
I-Wei Chang 1,2 , Jui-Wei Lin 3
1
Department of Pathology, E-DA Hospital/I-Shou University
2
Institute of Biotechnology and Chemical Engineering, I-Shou University
3
Department of Pathology , Kaohsiung Chang Gung Memorial Hospital, Taiwan
Background: Ganglioglioma (GG) is an uncommon brain parenchymal neoplasm. Although most cases
have indolent clinical behavior, a subgroup of GGs with anaplastic change in the glial component has
aggressive behavior and less favorable outcome. O6-methylguanine DNA methyltransferase (MGMT)
is a DNA repair protein that removes mutagenic and cytotoxic adducts from O6-guanine in DNA. Lack
of MGMT protein expression immunohistochemically is related to drug responses in patients of
malignant glioma treated with alkylating agents. EGFR is the most frequently amplified gene in
glioblastoma and associated with tumor invasiveness, angiogenesis, poor survival, and resistance to
radiation therapy. To elucidate the relationship between the statuses of the MGMT as well as EGFR
proteins and the tumor grading and prognosis, we conduct this study.
Methods: Clinicopathologic and immunohistochemical study of nine cases was performed.
Results: This series included four men and five women with a mean age of 21.4 years at first surgery.
Immunohistochemically, the MGMT and EGFR protein expressions tended to be more intensive in
anaplastic GG, corresponding to the worse prognostic predictive value of 3+ MGMT and 2+ EGFR
staining in glial cell component, as well as 1+ EGFR staining in neuronal cell components.
Conclusions: The series showed that MGMT and EGFR protein expressions tended to be more
intensive in anaplastic ganglioglioma.
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