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No 88 (PO 2)
Assessment of early manifestation of anthracycline-induced cardiomyopathy in
patients with preserved left ventricular ejection fraction
Reiko Mizuno 1 , Shinichi Fujimoto 2 , Yasuyuki Okamoto 1
1 Central Clinical Laboratory, Nara Medical University, 2 Center for Education Development, Nara
Medical University, Japan
Aim: Cardiac side effect of anthracycline limits its potential utility. Recent studies have reported that
latent anthracycline-induced cardiomyopathy already exists even in patients with preserved left
ventricular (LV) ejection fraction (EF). We investigated LV mechanical dyssynchrony in
anthracycline-induced cardiomyopathy with preserved LVEF.
Methods: We studied forty-seven patients with non-Hodgkin’s lymphoma who were previously treated
with anthracycline repeatedly. All patients had no history of cardiac disease and showed preserved
LVEF (≥ 60%). Myocardial strain rate obtained with speckle tracking was used to assess ventricular
synchrony. Time to regional peak strain rate was measured in 12 LV segments from the apical 4- and 2-
chamber views and standard deviation (SD) in all 12 segments was measured as an estimate of LV
dyssynchrony. Also the relationship between SD and LVEF was assessed. Thirty-eight healthy
volunteers served as controls.
Results: Although LVEF was preserved in all patients, it was significantly decreased compared with
controls. SD of time to peak strain rate was significantly greater in patients than controls. SD was
negatively correlated with LVEF in patients.
Conclusion: This study suggests that LV mechanical dyssynchrony exists and causes latent LV
dysfunction in patients with anthracycline-induced cardiomyopathy with preserved LVEF.
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