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Contents Section I Classes of Cell-Penetrating Peptides......................................................................1 Chapter 1 The Tat-Derived Cell-Penetrating Peptide ................................................................3 Eric Vivès and Bernard Lebleu Chapter 2 Penetratins................................................................................................................23 Edmond Dupont, Alain Joliot, and Alain Prochiantz Chapter 3 Transportans.............................................................................................................53 Margus Pooga, Mattias Hällbrink, and Ülo Langel Chapter 4 Model Amphipathic Peptides ..................................................................................71 Johannes Oehlke, Burkhard Wiesner, and Michael Bienert Chapter 5 Signal Sequence-Based Cell-Penetrating Peptides and Their Applications for Gene Delivery ....................................................................................................93 May C. Morris, Laurent Chaloin, Frédéric Heitz, and Gilles Divita Chapter 6 Hydrophobic Membrane Translocating Sequence Peptides .................................115 Kristen Sadler, Yao-Zhong Lin, and James P. Tam Chapter 7 Arginine-Rich Molecular Transporters for Drugs: The Role of Backbone and Side Chain Variations on Cellular Uptake .....................................................141 Jonathan B. Rothbard, Erik Kreider, Kanaka Pattabiraman, Erin T. Pelkey, Christopher L. VanDeusen, Lee Wright, Bryan L. Wylie, and Paul A. Wender
Section II Mechanisms of Cell Penetration and Interactions of Cell-Penetrating Peptides with Plasma Membranes and Lipid Models ......................................161 Chapter 8 Interactions of Cell-Penetrating Peptides with Membranes .................................163 Laurent Chaloin, Nicole Van Mau, Gilles Divita and Frédéric Heitz Chapter 9 Structure Prediction of CPPs and Iterative Development of Novel CPPs ...........187 Olivier Bouffioux, Frédéric Basyn, René Rezsohazy, and Robert Brasseur Chapter 10 Biophysical Studies of Cell-Penetrating Peptides.................................................223 Astrid Gräslund and L.E. Göran Eriksson Chapter 11 Toxicity and Side Effects of Cell-Penetrating Peptides........................................245 Margus Pooga, Anna Elmquist, and Ülo Langel Chapter 12 Quantification of Cell-Penetrating Peptides and Their Cargoes...........................263 Maria Lindgren, Mattias Hällbrink, and Ülo Langel Chapter 13 Kinetics of Uptake of Cell-Penetrating Peptides..................................................277 Matjazˇ Zorko, Mattias Hällbrink, and Ülo Langel Chapter 14 Signal Peptides ......................................................................................................295 Kenta Nakai Section III Applications of Cell-Penetrating Peptides ........................................................325 Chapter 15 Cell-Penetrating Peptide Conjugations and Magnetic Cell Labels ......................327 Ching-Hsuan Tung and Ralph Weissleder
Page 2 and 3: CELL- PENETRATING PEPTIDES Processe
Page 4 and 5: Pharmacology and Toxicology: Basic
Page 7 and 8: Library of Congress Cataloging-in-P
Page 9 and 10: to the handbook are prominent resea
Page 11 and 12: REFERENCES 1. Green, M. and Loewens
Page 14 and 15: Contributors Mats Andersson Microbi
Page 16 and 17: Erin T. Pelkey Department of Chemis
Page 20: Chapter 16 Cell-Penetrating Peptide
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Page 26 and 27: The Tat-Derived Cell-Penetrating Pe
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Page 45 and 46: 24 Cell-Penetrating Peptides: Proce
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48 Cell-Penetrating Peptides: Proce
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50 Cell-Penetrating Peptides: Proce
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3 Transportans Margus Pooga, Mattia
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Transportans 55 Indeed, galparan is
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Transportans 57 especially the endo
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Transportans 59 In the penetration
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Transportans 61 A 21-mer antisense
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Transportans 63 Commonly, the prote
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Transportans 65 antibiotin antibodi
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Transportans 67 For cross-linking o
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Transportans 69 and still retain ef
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Model Amphipathic Peptides 73 its D
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Model Amphipathic Peptides 75 pmol/
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TABLE 4.1 Internalization of Peptid
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TABLE 4.2 Internalization of Peptid
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Model Amphipathic Peptides 81 relat
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Model Amphipathic Peptides 87 A cat
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Model Amphipathic Peptides 89 At th
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Model Amphipathic Peptides 91 16. H
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Signal Sequence-Based Cell-Penetrat
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116 Cell-Penetrating Peptides: Proc
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Interactions of Cell-Penetrating Pe
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Structure Prediction of CPPs and It
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FIGURE 9.7 (Color Figure 9.7 follow
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FIGURE 9.8 The center of the figure
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Biophysical Studies of Cell-Penetra
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Toxicity and Side Effects of Cell-P
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Kinetics of Uptake of Cell-Penetrat
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Cell-Penetrating Peptide Conjugatio
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FIGURE 15.9 (Color Figure 15.9 foll
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Cell-Penetrating Peptides as Vector
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TABLE 16.1 Examples of Transport of
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CPP 2 Cargo or mRNA CAP Antisense A
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Microbial Membrane-Permeating Pepti
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Index A Abaecin, 129 Abz radiolabel
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Index 399 Diffraction, 168 Disulphi
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Index 401 structure prediction, 187
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Index 403 pRB proteins, Tat-E1A bin
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Index 405 lipid perturbation (secon
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