crc press - E-Lib FK UWKS

More documents

Recommendations

Info

Cell-Penetrating Peptide Conjugations and Magnetic Cell Labels 343 H 2N GRKKRRQRRRGYK-NH 2 Bound (nmole) 5 4 3 2 1 0 0 - OOC N C N N COO - O Gd +3 FIGURE 15.10 Top: Chemical structure of Tat-DOTA-Gd. The center ion can be replaced with Dy or In. Center: Uptake of Tat-DOTA- 111 In and DOTA- 111 In into mouse lymphocytes. Bottom: MR image of unlabeled (left) and Gd-Tat labeled cells (right) embedded in agar (T1 weighted spin-echo (TR/TE) 300/11). The labeled lymphocytes appear markedly hyperintense and are readily detectable. (From Bhorade, R. et al., Bioconjug. Chem., 11, 301, 2000. With permission.) N 100 200 Added (nmole) COO -
344 Cell-Penetrating Peptides: Processes and Applications REFERENCES 1. Dubowchik, G.M. and Walker, M.A., Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs, Pharmacol. Ther., 83, 67, 1999. 2. Reddy, J.A. and Low, P.S., Folate-mediated targeting of therapeutic and imaging agents to cancers, Crit. Rev. Ther. Drug Carrier Syst., 15, 587, 1998. 3. Marecos, E. et al., Antibody-mediated vs. nontargeted delivery in a human small cell lung carcinoma model, Bioconjug. Chem., 9, 184, 1998. 4. Rojas, M. et al., Genetic engineering of proteins with cell membrane permeability, Nat. Biotechnol., 16, 370, 1998. 5. Prochiantz, A., Messenger proteins: homeoproteins, Tat and others, Curr. Opin. Cell Biol., 12, 400, 2000. 6. Lindgren, M. et al., Cell-penetrating peptides, Trends Pharmacol. Sci., 21, 99, 2000. 7. Fawell, S. et al., Tat-mediated delivery of heterologous proteins into cells, Proc. Natl. Acad. Sci. U.S.A., 91, 664, 1994. 8. Vivés, E. et al., A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus, J. Biol. Chem., 272, 16010, 1997. 9. Derossi, D. et al., Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent, J. Biol. Chem., 271, 18188, 1996. 10. Pooga, M. et al., Cell penetration by transportan, FASEB. J., 12, 67, 1998. 11. Soomets, U. et al., Deletion analogues of transportan, Biochim. Biophys. Acta, 1467, 165, 2000. 12. Avrameas, A. et al., Polyreactive anti-DNA monoclonal antibodies and a derived peptide as vectors for the intracytoplasmic and intranuclear translocation of macromolecules, Proc. Natl. Acad. Sci. U.S.A., 95, 5601, 1998. 13. Phelan, A. et al., Intercellular delivery of functional p53 by the herpesvirus protein VP22, Nat. Biotechnol., 16, 440, 1998. 14. Elliott, G. and O’Hare, P., Intercellular trafficking and protein delivery by a herpesvirus structural protein, Cell, 88, 223, 1997. 15. Sheldon, K. et al., Loligomers: design of de novo peptide-based intracellular vehicles, Proc. Natl. Acad. Sci. U.S.A., 92, 2056, 1995. 16. Zhang, L. et al., Preparation of functionally active cell-permeable peptides by singlestep ligation of two peptide modules, Proc. Natl. Acad. Sci. U.S.A., 95, 9184, 1998. 17. Efthymiadis, A. et al., The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties, J. Biol. Chem., 273, 1623, 1998. 18. Pepinsky, R.B. et al., Specific inhibition of a human papillomavirus E2 trans-activator by intracellular delivery of its re<strong>press</strong>or, DNA Cell Biol., 13, 1011, 1994. 19. Anderson, D.C. et al., Tumor cell retention of antibody Fab fragments is enhanced by an attached HIV TAT protein-derived peptide, Biochem. Biophys. Res. Commun., 194, 876, 1993. 20. Bayley, H., Protein therapy-delivery guaranteed, Nat. Biotechnol., 17, 1066, 1999. 21. Nagahara, H. et al., Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration, Nat. Med., 4, 1449, 1998. 22. Vocero–Akbani, A.M. et al., Killing HIV-infected cells by transduction with an HIV protease- activated caspase-3 protein, Nat. Med., 5, 29, 1999. 23. Pooga, M. et al., Cellular translocation of proteins by transportan, FASEB. J., 15, 1451, 2001. 24. Lin, Y.Z. et al., Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence, J. Biol. Chem., 270, 14255, 1995.
Page 2 and 3:
CELL- PENETRATING PEPTIDES Processe
Page 4 and 5:
Pharmacology and Toxicology: Basic
Page 7 and 8:
Library of Congress Cataloging-in-P
Page 9 and 10:
to the handbook are prominent resea
Page 11 and 12:
REFERENCES 1. Green, M. and Loewens
Page 14 and 15:
Contributors Mats Andersson Microbi
Page 16 and 17:
Erin T. Pelkey Department of Chemis
Page 18 and 19:
Contents Section I Classes of Cell-
Page 20:
Chapter 16 Cell-Penetrating Peptide
Page 24 and 25:
1 CONTENTS 0-8493-1141-1/02/$0.00+$
Page 26 and 27:
The Tat-Derived Cell-Penetrating Pe
Page 28 and 29:
Page 30 and 31:
Page 32 and 33:
Page 34 and 35:
Page 36 and 37:
Page 38 and 39:
Page 40 and 41:
Page 42:
Page 45 and 46:
24 Cell-Penetrating Peptides: Proce
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 74 and 75:
3 Transportans Margus Pooga, Mattia
Page 76 and 77:
Transportans 55 Indeed, galparan is
Page 78 and 79:
Transportans 57 especially the endo
Page 80 and 81:
Transportans 59 In the penetration
Page 82 and 83:
Transportans 61 A 21-mer antisense
Page 84 and 85:
Transportans 63 Commonly, the prote
Page 86 and 87:
Transportans 65 antibiotin antibodi
Page 88 and 89:
Transportans 67 For cross-linking o
Page 90 and 91:
Transportans 69 and still retain ef
Page 92 and 93:
4 CONTENTS 0-8493-1141-1/02/$0.00+$
Page 94 and 95:
Model Amphipathic Peptides 73 its D
Page 96 and 97:
Model Amphipathic Peptides 75 pmol/
Page 98 and 99:
TABLE 4.1 Internalization of Peptid
Page 100 and 101:
TABLE 4.2 Internalization of Peptid
Page 102 and 103:
Model Amphipathic Peptides 81 relat
Page 104 and 105:
Page 106 and 107:
Page 108 and 109:
Model Amphipathic Peptides 87 A cat
Page 110 and 111:
Model Amphipathic Peptides 89 At th
Page 112 and 113:
Model Amphipathic Peptides 91 16. H
Page 114 and 115:
5 CONTENTS 0-8493-1141-1/02/$0.00+$
Page 116 and 117:
Signal Sequence-Based Cell-Penetrat
Page 118 and 119:
Page 120 and 121:
Page 122 and 123:
Page 124 and 125:
Page 126 and 127:
Page 128 and 129:
Page 130 and 131:
Page 132 and 133:
Page 134:
Page 137 and 138:
116 Cell-Penetrating Peptides: Proc
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 184 and 185:
8 CONTENTS 0-8493-1141-1/02/$0.00+$
Page 186 and 187:
Interactions of Cell-Penetrating Pe
Page 188 and 189:
Page 190 and 191:
Page 192 and 193:
Page 194 and 195:
Page 196 and 197:
Page 198 and 199:
Page 200 and 201:
Page 202 and 203:
Page 204 and 205:
Page 206 and 207:
Page 208 and 209:
9 CONTENTS 0-8493-1141-1/02/$0.00+$
Page 210 and 211:
Structure Prediction of CPPs and It
Page 212 and 213:
Page 214 and 215:
Page 216 and 217:
Page 218 and 219:
Page 220 and 221:
Page 222 and 223:
Page 224 and 225:
Page 226 and 227:
Page 228 and 229:
FIGURE 9.7 (Color Figure 9.7 follow
Page 230 and 231:
FIGURE 9.8 The center of the figure
Page 232 and 233:
Page 234 and 235:
Page 236 and 237:
Page 238 and 239:
Page 240 and 241:
Page 242 and 243:
Page 244 and 245:
10 CONTENTS 0-8493-1141-1/02/$0.00+
Page 246 and 247:
Biophysical Studies of Cell-Penetra
Page 248 and 249:
Page 250 and 251:
Page 252 and 253:
Page 254 and 255:
Page 256 and 257:
Page 258 and 259:
Page 260 and 261:
Page 262 and 263:
Page 264 and 265:
Page 266 and 267:
11 CONTENTS 0-8493-1141-1/02/$0.00+
Page 268 and 269:
Toxicity and Side Effects of Cell-P
Page 270 and 271:
Page 272 and 273:
Page 274 and 275:
Page 276 and 277:
Page 278 and 279:
Page 280 and 281:
Page 282:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 298 and 299:
13 CONTENTS 0-8493-1141-1/02/$0.00+
Page 300 and 301:
Kinetics of Uptake of Cell-Penetrat
Page 302 and 303:
Page 304 and 305:
Page 306 and 307:
Page 308 and 309:
Page 310 and 311:
Page 312 and 313:
Page 314: Kinetics of Uptake of Cell-Penetrat
Page 317 and 318: 296 Cell-Penetrating Peptides: Proc
Page 348 and 349: 15 CONTENTS 0-8493-1141-1/02/$0.00+
Page 350 and 351: Cell-Penetrating Peptide Conjugatio
Page 362 and 363: FIGURE 15.9 (Color Figure 15.9 foll
Page 370 and 371: Cell-Penetrating Peptides as Vector
Page 374 and 375: TABLE 16.1 Examples of Transport of
Page 380 and 381: CPP 2 Cargo or mRNA CAP Antisense A
Page 384: Cell-Penetrating Peptides as Vector
Page 400 and 401: Microbial Membrane-Permeating Pepti
Page 414 and 415:
Microbial Membrane-Permeating Pepti
Page 416 and 417:
Microbial Membrane-Permeating Pepti
Page 418 and 419:
Index A Abaecin, 129 Abz radiolabel
Page 420 and 421:
Index 399 Diffraction, 168 Disulphi
Page 422 and 423:
Index 401 structure prediction, 187
Page 424 and 425:
Index 403 pRB proteins, Tat-E1A bin
Page 426 and 427:
Index 405 lipid perturbation (secon
show all

crc press - E-Lib FK UWKS

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?