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50 Cell-Penetrating Peptides: Processes and Applications<br />

49. Chen, Y.N. et al., Selective killing of transformed cells by cyclin/cyclin-dependent<br />

kinase 2 antagonists, Proc. Natl. Acad. Sci. USA, 96, 4325, 1999.<br />

50. Sharma, S.K. et al., Identification of E2F-1/Cyclin A antagonists, Bioorg. Med. Chem.<br />

Lett., 11, 2449, 2001.<br />

51. Lin, X. et al., SSeCKS, a major protein kinase C substrate with tumor sup<strong>press</strong>or<br />

activity, regulates G(1) — >S progression by controlling the ex<strong>press</strong>ion and cellular<br />

compartmentalization of cyclin D, Mol. Cell Biol., 20, 7259, 2000.<br />

52. Herbert, T.P. et al., Rapid induction of apoptosis mediated by peptides that bind<br />

initiation factor eIF4E, Curr. Biol., 10, 793, 2000.<br />

53. Hutton, F.G. et al., Consequences of disruption of the interaction between p53 and<br />

the larger adenovirus early region 1B protein in adenovirus E1 transformed human<br />

cells, Oncogene, 19, 452, 2000.<br />

54. Mittelman, J.M. and Gudkov, A.V., Generation of p53 sup<strong>press</strong>or peptide from the<br />

fragment of p53 protein, Somat. Cell Mol. Genet., 25, 115, 1999.<br />

55. Komarov, P.G. et al., A chemical inhibitor of p53 that protects mice from the side<br />

effects of cancer therapy, Science, 285, 1733, 1999.<br />

56. Giorello, L., et al., Inhibition of cancer cell growth and c-Myc transcriptional activity<br />

by a c-Myc helix 1-type peptide fused to an internalization sequence, Cancer Res.,<br />

58, 3654, 1998.<br />

57. Pescarolo, M.P. et al., A retro-inverso peptide homologous to helix 1 of c-Myc is a<br />

potent and specific inhibitor of proliferation in different cellular systems, FASEB J.,<br />

15, 31, 2001.<br />

58. Liu, G.S. et al., Protein kinase C-epsilon is responsible for the protection of preconditioning<br />

in rabbit cardiomyocytes, J. Mol. Cell Cardiol., 31, 1937, 1999.<br />

59. Dostmann, W.R. et al., Highly specific, membrane-permeant peptide blockers of<br />

cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation, Proc.<br />

Natl. Acad. Sci. USA, 97, 14772, 2000.<br />

60. Hall, H. et al., Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and<br />

neurite outgrowth by a cell-membrane permeable phosphopeptide, Curr. Biol., 6, 580,<br />

1996.<br />

61. Peck, D. and Isacke, C.M., Hyaluronan-dependent cell migration can be blocked by<br />

a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325, J.<br />

Cell Sci., 111, 1595, 1998.<br />

62. Calvet, S. et al., Identification of a signaling pathway activated specifically in the<br />

somatodendritic compartment by a heparan sulfate that regulates dendrite growth, J.<br />

Neurosci., 18, 9751, 1998.<br />

63. Bardelli, A. et al., A peptide representing the carboxyl-terminal tail of the met receptor<br />

inhibits kinase activity and invasive growth, J. Biol. Chem., 274, 29274, 1999.<br />

64. Nielsen, P.E., Peptide nucleic acids as therapeutic agents, Curr. Opin. Struct. Biol.,<br />

9, 353, 1999.<br />

65. Villa, R. et al., Inhibition of telomerase activity by a cell-penetrating peptide nucleic<br />

acid construct in human melanoma cells, FEBS Lett., 473, 241, 2000.<br />

66. Simmons, C.G. et al., Synthesis and membrane permeability of PNA-peptide conjugate,<br />

Bioorg. Med. Chem. Lett., 7, 3001, 1997.<br />

67. Pooga, M. et al., Cell penetrating PNA constructs regulate galanin receptor levels and<br />

modify pain transmission in vivo, Nat. Biotechnol., 16, 857, 1998.<br />

68. Maizel, A. et al., A short region of its homeodomain is necessary for engrailed nuclear<br />

export and secretion, Development, 126, 3183, 1999.<br />

69. Joliot, A. et al., Identification of a signal sequence necessary for the unconventional<br />

secretion of engrailed homeoprotein, Curr. Biol., 8, 856, 1998.

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