VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

More documents

Recommendations

Info

our experience, this has a seven-year projection in terms of survival and DFS of 62% and 59% respectively. The relationships between survival and prognostic factors are unclear in this particular lymphoma. A randomized study was set up in October 1992 by the EBMT/UK Lymphoma Groups to investigate these questions. A similar study carried out on other poor-prognosis lymphomas would undoubtely prove useful. The decision to undertake transplantation is influenced by procedure related mortality which in our experience is 11%. In 1988, Goldstone reported similar mortality figures (13%). The use of hematopoietic growth factors or peripheral stem cells would reduce this problem
Med 104:757-765,1986. 11. Velasquez WS, Jagannath S, Tucker SL, et al: Risk classification as the basis for clinical staging of diffuse large-cell lymphoma derived from 10-year survival data. Blood 2:551-557,1989. 12. Coiffier B, Lepage E: Prognosis of aggressive lymphomas: A study of five prognostic Models with patients included in the LNH-84 regimen. Blood 2:558-564,1989. 13. Vitolo U, Bertini M, Brusamolino E, et al: MACOP-B treatment in diffuse large-cell lymphoma: identification of prognostic Groups in an italian Multicenter Study. J Clin Oncol 2:219-227,1992. 14. Coleman, Picozzi VJ, Cox RS, et al: Treatment of lymphoblastic lymphoma in adults. J Clin Oncol 4:1628-1637,1986. 15. Cabanillas F, Hagemeister FB, McLaughlin P, et al: Results of MIME salvage regimen for recurrent or refractory lymphoma. J Clin Oncol 3:407-412,1987. 16. Velasquez WS, Cabanillas F, Salvador P, et al: Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone. Blood 1:117-122,1988. 17. Phillips LG, Herzig RH, Lazarus HM, et al: Treatment of resistant malignant lymphoma with cyclophosphamide, total body irradiation, and transplantation of cryopreserved autologous marrow. N Engl J Med 24:1557-1561,1984. 18. Armitage JO, Jagannath S, Spitzer G, et al: High dose therapy and autologous marrow transplantation as salvage treatment for patients with diffuse large cell lymphoma. Eur J Cancer Clin Oncol 7:871-877,1986. 19. Petersen FB, Appelbaum FR, Hill R, et al: Autologous marrow transplantation for malignant lymphoma: A report of 101 cases from Seattle. J Clin Oncol 4:638-647,1990. 20. Mascret B, Maraninchi D, Gastaut JA, et al: Treatment of malignant lymphoma with high dose of chemo or chemoradiotherapy and bone marrow transplantation. Eur J Cancer Clin Oncol 4:461-471,1985. 21. Philip T, Armitage JO, Spitzer G, et al: High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. N Eng J Med 24:1493- 1498,1987. 22. Braine HG, Santos GW, Kaizer H, et al: Treatment of poor prognosis non-Hodgkin's lymphoma using cyclophosphamide and total body irradiation regimens with autologous bone marrw rescue. Bone Marrow Transplant 2:7-14,1987. 23. Philip T, Hartmann O, Biron P, et al: High-dose therapy and autologous bone marrow transplantation in partial remission after first-line induction therapy for diffuse non-Hodgkin's lymphoma. J Clin Oncol 7:1118-1124,1988. 24. Gribben JG, Goldstone AH, Linch DC, et al: Effectiveness of high-dose combination chemotherapy and autologous bone marrow transplantation for patients with non- Hodgkin's lymphomas who are still responsive to conventional-dose therapy. J Clin Oncol 11:1621-1629,1989. 25. Philip T, Chauvin F, Armitage J, et al: Parma International Protocol: Pilot study of DHAP followed by involved-field radiotherapy and BEAC with autologous bone marrow transplantation. Blood 7:1587-1592,1991. 26. Goldstone AH, Gribben J, Dones L: Fourth report of EBMT experience of autologous bone marrow transplantation in lymphoma. Bone Marrow Transplant 2(Suppl 1):200-203,1987. 27. Gulati SC, Shank B, Black P, et al: Autologous bone marrow transplantation for patients with poor-prognosis lymphoma. J Clin Oncol 8:1303-1313,1988. 28. Goldstone AH, Singer CRJ, Gribben JG, et al: Fifth report of EBMTG experience of ABMT in malignant lymphoma. Bone Marrow Transpl 3(Suppl 1): 33-36,1988. 29. Armitage JO: Bone marrow transplantation in the treatment of patients with lymphoma. Blood 7:1749-1758,1989. SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 79
Page 1:
Autologous Bone Marrow Transplantat
Page 5 and 6:
CONTENTS nviAum TMLHTA'I OTT! 7 A l
Page 7 and 8:
AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 9 and 10:
TREATMENT OF NONSMALL CELL LUNG CAN
Page 11:
SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 15:
Session I: Leukemia
Page 18 and 19:
TRIAL PROGRESS The trial opened in
Page 20 and 21:
Table 1. Achievement of Second Remi
Page 22 and 23:
ALLOGENEIC VERSUS AUTOLOGOUS BONE M
Page 24 and 25:
pts). The other 56 pts are too earl
Page 26 and 27:
Figure 1 EORTC-GIMEMA AML 8 A EORTC
Page 28 and 29:
PATIENTS AND METHODS Patients The B
Page 30 and 31:
Thus, as the results of some ongoin
Page 32 and 33:
COMPARISON OF INTENSIVE CONSOLIDATI
Page 34 and 35:
over, 13 pts who had received ICC1
Page 37:
Session II: Future Directions
Page 40 and 41:
in a previous report 3 . Analysis a
Page 42 and 43:
Engraftment of granulocyte, monocyt
Page 44 and 45:
0.2 - 0.1 - ABMT with mAb purging f
Page 46 and 47:
ENHANCED REGENERATION OF NATURAL KI
Page 48 and 49:
RESULTS The in vivo immune effects
Page 50 and 51: 16. Rizzoli V, Mangoni L, Carlo-Ste
Page 52 and 53: hydroperoxycyclophosphamide (4HC)-t
Page 54 and 55: survival in patients undergoing ABM
Page 56 and 57: IMMUNOTHERAPY OF AML AFTER ABMT - S
Page 58 and 59: Otherwise toxicity was mild to mode
Page 60 and 61: Therapy. Amsterdam Elsevier 1987;89
Page 62 and 63: 200 IL6 in serum 44 SIXTH INTERNATI
Page 64 and 65: sodes), fewer days of i.v. antibiot
Page 67: Session III: Myeloma
Page 70 and 71: trary, in case of adequate collecti
Page 72 and 73: tion is considered, and all the mor
Page 74 and 75: Table 3: Cost effectiveness of high
Page 77: Session W: Lymphoma
Page 80 and 81: METHODS Selection of patients and t
Page 82 and 83: marrow treatment. Am J Med 85:829,1
Page 84 and 85: HIGH DOSE THERAPY WITH HEMATOPOIETI
Page 86 and 87: in TC 19 medium (Flobio), with an h
Page 88 and 89: progression for a long time after A
Page 90 and 91: Table 2. STATUS AT GRAFT Remission
Page 92 and 93: IL Figura 3 70 SIXTH INTERNATIONAL
Page 94 and 95: ( 5 ) lowed by ABMT than refractory
Page 96 and 97: 74 Figure 4 Low grade lymphoma - pr
Page 98 and 99: (range 15-55); 68 males and 32 fema
Page 102 and 103: 30. Colombat P, Gorin NC, Lemonnier
Page 104 and 105: 82 OVERALL SURUIWL from ABUT (accor
Page 107 and 108: PROGNOSTIC FACTORS IN ADVANCED STAG
Page 109 and 110: REFERENCES 1. Chopra R, Mc Millan A
Page 111 and 112: lished data to attempt to assess th
Page 113 and 114: 1992;10:175-7. 3. McMillan A, Golds
Page 115 and 116: B. DAILY DAY AGENT DOSE -7 -6 -5 -4
Page 117 and 118: cohort with HR treated with BEC-2 i
Page 119 and 120: p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
Page 121 and 122: TABLE 3. TOXICITY BEC TAVe TMJ as 2
Page 123 and 124: ies. 10 Longer blood half-lives hav
Page 125 and 126: agents have been developed cautious
Page 127 and 128: Table 1. Radioisotopes for RIT. Pur
Page 129 and 130: The treatment criterion in this stu
Page 131 and 132: more than 80% of the cases. Patient
Page 133 and 134: Disease Free Survival 800 Time •
Page 135: Session VI: Breast Cancer
Page 138 and 139: achieved a complete remission survi
Page 140 and 141: acil, vincristine, prednisone (CMFV
Page 142 and 143: t: 3 en a in S « J •S •> c ai
Page 144 and 145: LONG TERM FOLLOW UP OF POOR PROGNOS
Page 146 and 147: tors both for progression-free surv
Page 148 and 149: 222 INDUCTION PHASE ESTROGEN RECEPT
Page 150 and 151:
THE PHARMACOLOGY OF INTENSIVE CYCLO
Page 152 and 153:
PK VARIABILITY OF CPA/CDDP/BCNU Whe
Page 154 and 155:
5. Groshow LB, Piantadosi S, Santos
Page 157 and 158:
- Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
Page 159 and 160:
normal CD34+ progenitor cells
Page 161 and 162:
sequence analysis of the human haem
Page 163 and 164:
Bielefeld, FRG) or control medium w
Page 165 and 166:
3. Koeffler HP, and Golde DW: Chron
Page 167 and 168:
ply infected with supernatants from
Page 169 and 170:
controls must be carefully matched
Page 171 and 172:
Fig. IB: GPI isozyme analysis of 2
Page 173 and 174:
PROCESSING OF STEM CELLS FOR TRANSP
Page 175 and 176:
in progress using marker genes to l
Page 177 and 178:
Table 1. Factors Affecting Quality
Page 179:
Figure 2 .2 A Refractory/Relapsed L
Page 183 and 184:
HIGH DOSE CHEMOTHERAPY IN GERM CELL
Page 185 and 186:
carboplatin and etoposide with auto
Page 187 and 188:
HIGH DOSE THERAPY IN GERM CELL TUMO
Page 189 and 190:
Confusing data come out from early
Page 191:
Session Mill: Lung Cancer
Page 194 and 195:
Of the 14 limited stage patients in
Page 196 and 197:
esponses with persistent nodular di
Page 198 and 199:
hanced, detection of initial failur
Page 200 and 201:
Cellules. Bull Cancer 1987;74:587-5
Page 202 and 203:
30 36 42 48 54 60 66 72 78 84 12 18
Page 204 and 205:
Table 2: Toxicity of CBP Regimen fo
Page 206 and 207:
TREATMENT OF NONSMALL CELL LUNG CAN
Page 208 and 209:
Table 1. Combination Chemotherapy R
Page 210 and 211:
Table 6. Hematological Data of the
Page 212 and 213:
ence in survival among the three hi
Page 215:
Session IX: Ovarian Cancer
Page 218 and 219:
lymph node involvement or parenchym
Page 220 and 221:
higher frequencies of neurotoxicity
Page 222 and 223:
12. Ovarian Cancer Meta-Analysis Pr
Page 224 and 225:
Table 2. Randomized Trials Employin
Page 226 and 227:
BONE MARROW TRANSPLANTATION FOR OVA
Page 228 and 229:
1). Data from the survey was combin
Page 230 and 231:
carboplatinum and ifosfamide. The s
Page 233:
Session X: Sarcoma
Page 236 and 237:
ated doses in a recent Pediatric On
Page 238 and 239:
cytokines to reduce hospitalization
Page 240 and 241:
TABLE 2 Dose Escalation Schedule Do
Page 243 and 244:
CHRONIC MYELOGENOUS LEUKEMIA WITH B
Page 245 and 246:
DISCUSSION In this study, the use o
Page 247 and 248:
AUTOGRAFTING IN CHRONIC MYELOID LEU
Page 249 and 250:
Table 1 Remission Deaths Graft Hema
Page 251 and 252:
16 (800 mg/m2 per day for two conse
Page 253:
Session XII: CNS
Page 256 and 257:
1.2 Description of the study The tr
Page 258 and 259:
3. Conclusion In conclusion, treatm
Page 260 and 261:
3. Conclusion Hematological toxicit
Page 263:
Session XIII: Peripheral Stem Cells
Page 266 and 267:
Crouse, 1992). In the present repor
Page 268 and 269:
with no evidence of systemic diseas
Page 270 and 271:
Administration of rhSCF at doses of
Page 272 and 273:
In summary, the ligand for c-kit ha
Page 274 and 275:
AUTOGRAFTING WITH G-CSF-MOBILIZED B
Page 276 and 277:
cells and CD34+ cells observed in t
Page 278 and 279:
6. Brugger W, Bross K, Frisch J, et
Page 280 and 281:
100 -l Collection Efficiency Figure
Page 282 and 283:
MATERIALS AND METHODS PATIENTS. Pat
Page 284 and 285:
None of the patients included in ar
Page 286 and 287:
9. Aurer I, Ribas A, Gale RP. What
Page 288 and 289:
246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
Page 291 and 292:
AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 293 and 294:
SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 295 and 296:
SUMMARY: AUTOLOGOUS MARROW TRANSPLA
Page 297 and 298:
mor. The obverse of this coin is po
Page 299 and 300:
treated at Memorial Hospital in New
Page 301 and 302:
Contributors and Participants Tause
Page 303 and 304:
Leonard Kalman, Hematology/Oncology
Page 305:
D.R. Sutherland, Oncology Research,
show all

VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?