VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

graphies are given in Table 1. In all 58 patients were treated. One patient developed
spinal cord compression during therapy and had his preparative regimen
interrupted. This patient is not included in the analysis. Most had multiple prior
chemotherapy regimens (median 2) and had received radiotherapy to axial
(craniospinal, whole abdomen or pelvis; n=32) or non axial (n=17) sites.
Response data is given in Table 2. The overall response rate in the 50 patients
with évaluable disease was 70% (19CR, 16PR). The data for sarcomas is
given independently in Table 2. Overall 33 sarcomas were treated. In 28 patients
évaluable for response there were 13CR and 6PR for a response rate of 68% (19/
28). Median time to progression was 4 months. For the patients who achieved
CR and survived to day 60 however, 9/11 remain progression free (Kaplan
Meier estimate 80% at 1 year) with a median follow-up of 13 months.
Patients who received a CBDCA dose of > 2000mg/M 2
had a significantly
higher CR rate than patients receiving less than this dose (11/20 vs. 2/13;
P