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progression for a long time after ABMT. It is too early to conclude that some of these patients are cured, but it appears urgent to initiate randomized studies to evaluate this approach in terms of disease free survival and overall survival. REFERENCES 1. ERSBOLL J, SCHULTZ HB, PEDERSEN-BJERGAARD J, NISSEN NI: Follicular Low grade non Hodgkin's lymphoma :long term outcome with or without tumour progression. Eur J Haemat 42:155-163,1989. 2. GALLACHER GJ, GREGORY WM, JONES AE et al: Follicular lymphoma: prognostic factors for response and survival. J Clin Oncol 4:1470-1480,1986. 3. ROMAGUERA JE, McLAUGHLIN P, NORTH L et al: Multivariate analysis of prognostic factors in stage IV follicular low—grade lymphoma: a risk model. J Clin Oncol 9:762-769,1991. 4. BIERMAN PJ, VOSE JM, KESSINGER A et al: High dose therapy with hematopoietic rescue for low grade non Hodgkin's lymphoma. Exp Haematol 17:231 (a), 1989. 5. COLOMBAT Ph, BINET Ch, LINASSIER C et al: High dose chemotherapy with autologous marrow transplantation in follicular lymphomas. Leukemia and Lymphoma, suppl. 7:3-6,1992. 6. FOUILLARD L, GORTN NC, LAPORTE JP et al: Feasibility of autologous bone marrow transplantation for early consolidation of follicular non Hodgkin's lymphoma. Eur J Haematol 46:279-284,1991. 7. FREDDMAN AS, RITZ J, NEUBERG D et al: Autologous bone marrow transplantation in 69 patients with a history of low grade B-cell non Hodgkin lymphoma. Blood 77:2524-2529,1991. 8. HORNING SJ: Results of high dose therapy + Bone Marrow Transplantation in low grade lymphoma. Proceedings on Meeting "Lymphoma the next questions" - ORLANDO, FLORIDA, April 2-4,1992. 9. ROHATINER AZS, PRICE CGA, DOREY E et al: Ablative therapy with autologous bone marrow transplantation as consolidation therapy for follicular lymphomas. Proceedings of the Fourth International Conference on Malignant Lymphoma - Lugano 60.83(a), 1990. 10. National Cancer Institute: Sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working-formulation for clinical use. Cancer 49:2112-2135,1982. 11. GORIN NC, DOUAY L, LAPORTE JP et al: Autologous bone marrow transplantation using marrow incubated with ASTA Z 7557 in adult acute leukaemia. Blood 67:1367-1376,1986. 12. FAVROT M.C., PHILIP I., PHILIP T.: Bone marrow purging procedure in Burkitt lymphoma with monoclonal antibodies and complement. Quantification by a liquid all culture monitoring system. Br J Haemat 64161-168,1986. 13. KAPLAN EL, MEIER P: Non parametric estimation from incomplete observations. J Am Star Assoc 53:457-481,1958. 14. PRICE CGA, MEERABUX J, MURTAGH S et al: The significance of circulating cells carrying t(14; 18) in long remission from follicular lymphoma. J Clin Oncol 9:1527- 1532,1991. 15. GRIBBEN JG, FREEDMAN AS, NEUBERG D et al: Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B cell lymphoma. N Engl J Med 325:1525-1533,1991. 66 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
TABLE 1. PATIENT CHARACTERISTICS No. of patients 42 SexM/F 12/21 Mean age (range) 38 (26-61) Histological type Follicular small cleaved 10 Follicular mixed 30 Follicular large cell 2 STATUS AT DIAGNOSIS Ann Arbor stage I 4 II 7 III 10 IV 21 Peripheral lymph nodes size < 5cm 17 5-10 cm 21 >10 cm 4 Bulky abdominal tumour 14 B symptoms 10 Number of extra nodal sites (stage IV) 1 (bone marrow) 14 >2 7 leukemic phase 2 STATUS AT GRAFT Remission status at transplant PR1 13 CR2 16 PR2 5 CR3 4 PR3 4 Sensitive relapse 29 CR2 16 PR2 5 CR3 4 PR3 4 Median duration of first CR (# 29 pts) 18 mo (4-70) (5 CR1 > 30 mo) SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 67
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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Session I: Leukemia
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TRIAL PROGRESS The trial opened in
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Table 1. Achievement of Second Remi
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ALLOGENEIC VERSUS AUTOLOGOUS BONE M
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pts). The other 56 pts are too earl
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Figure 1 EORTC-GIMEMA AML 8 A EORTC
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PATIENTS AND METHODS Patients The B
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Thus, as the results of some ongoin
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COMPARISON OF INTENSIVE CONSOLIDATI
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over, 13 pts who had received ICC1
Page 37: Session II: Future Directions
Page 40 and 41: in a previous report 3 . Analysis a
Page 42 and 43: Engraftment of granulocyte, monocyt
Page 44 and 45: 0.2 - 0.1 - ABMT with mAb purging f
Page 46 and 47: ENHANCED REGENERATION OF NATURAL KI
Page 48 and 49: RESULTS The in vivo immune effects
Page 50 and 51: 16. Rizzoli V, Mangoni L, Carlo-Ste
Page 52 and 53: hydroperoxycyclophosphamide (4HC)-t
Page 54 and 55: survival in patients undergoing ABM
Page 56 and 57: IMMUNOTHERAPY OF AML AFTER ABMT - S
Page 58 and 59: Otherwise toxicity was mild to mode
Page 60 and 61: Therapy. Amsterdam Elsevier 1987;89
Page 62 and 63: 200 IL6 in serum 44 SIXTH INTERNATI
Page 64 and 65: sodes), fewer days of i.v. antibiot
Page 67: Session III: Myeloma
Page 70 and 71: trary, in case of adequate collecti
Page 72 and 73: tion is considered, and all the mor
Page 74 and 75: Table 3: Cost effectiveness of high
Page 77: Session W: Lymphoma
Page 80 and 81: METHODS Selection of patients and t
Page 82 and 83: marrow treatment. Am J Med 85:829,1
Page 84 and 85: HIGH DOSE THERAPY WITH HEMATOPOIETI
Page 86 and 87: in TC 19 medium (Flobio), with an h
Page 90 and 91: Table 2. STATUS AT GRAFT Remission
Page 92 and 93: IL Figura 3 70 SIXTH INTERNATIONAL
Page 94 and 95: ( 5 ) lowed by ABMT than refractory
Page 96 and 97: 74 Figure 4 Low grade lymphoma - pr
Page 98 and 99: (range 15-55); 68 males and 32 fema
Page 100 and 101: our experience, this has a seven-ye
Page 102 and 103: 30. Colombat P, Gorin NC, Lemonnier
Page 104 and 105: 82 OVERALL SURUIWL from ABUT (accor
Page 107 and 108: PROGNOSTIC FACTORS IN ADVANCED STAG
Page 109 and 110: REFERENCES 1. Chopra R, Mc Millan A
Page 111 and 112: lished data to attempt to assess th
Page 113 and 114: 1992;10:175-7. 3. McMillan A, Golds
Page 115 and 116: B. DAILY DAY AGENT DOSE -7 -6 -5 -4
Page 117 and 118: cohort with HR treated with BEC-2 i
Page 119 and 120: p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
Page 121 and 122: TABLE 3. TOXICITY BEC TAVe TMJ as 2
Page 123 and 124: ies. 10 Longer blood half-lives hav
Page 125 and 126: agents have been developed cautious
Page 127 and 128: Table 1. Radioisotopes for RIT. Pur
Page 129 and 130: The treatment criterion in this stu
Page 131 and 132: more than 80% of the cases. Patient
Page 133 and 134: Disease Free Survival 800 Time •
Page 135: Session VI: Breast Cancer
Page 138 and 139:
achieved a complete remission survi
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acil, vincristine, prednisone (CMFV
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t: 3 en a in S « J •S •> c ai
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LONG TERM FOLLOW UP OF POOR PROGNOS
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tors both for progression-free surv
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222 INDUCTION PHASE ESTROGEN RECEPT
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THE PHARMACOLOGY OF INTENSIVE CYCLO
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PK VARIABILITY OF CPA/CDDP/BCNU Whe
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5. Groshow LB, Piantadosi S, Santos
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- Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
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normal CD34+ progenitor cells
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sequence analysis of the human haem
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Bielefeld, FRG) or control medium w
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3. Koeffler HP, and Golde DW: Chron
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ply infected with supernatants from
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controls must be carefully matched
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Fig. IB: GPI isozyme analysis of 2
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PROCESSING OF STEM CELLS FOR TRANSP
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in progress using marker genes to l
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Table 1. Factors Affecting Quality
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Figure 2 .2 A Refractory/Relapsed L
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HIGH DOSE CHEMOTHERAPY IN GERM CELL
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carboplatin and etoposide with auto
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HIGH DOSE THERAPY IN GERM CELL TUMO
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Confusing data come out from early
Page 191:
Session Mill: Lung Cancer
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Of the 14 limited stage patients in
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esponses with persistent nodular di
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hanced, detection of initial failur
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Cellules. Bull Cancer 1987;74:587-5
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30 36 42 48 54 60 66 72 78 84 12 18
Page 204 and 205:
Table 2: Toxicity of CBP Regimen fo
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TREATMENT OF NONSMALL CELL LUNG CAN
Page 208 and 209:
Table 1. Combination Chemotherapy R
Page 210 and 211:
Table 6. Hematological Data of the
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ence in survival among the three hi
Page 215:
Session IX: Ovarian Cancer
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lymph node involvement or parenchym
Page 220 and 221:
higher frequencies of neurotoxicity
Page 222 and 223:
12. Ovarian Cancer Meta-Analysis Pr
Page 224 and 225:
Table 2. Randomized Trials Employin
Page 226 and 227:
BONE MARROW TRANSPLANTATION FOR OVA
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1). Data from the survey was combin
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carboplatinum and ifosfamide. The s
Page 233:
Session X: Sarcoma
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ated doses in a recent Pediatric On
Page 238 and 239:
cytokines to reduce hospitalization
Page 240 and 241:
TABLE 2 Dose Escalation Schedule Do
Page 243 and 244:
CHRONIC MYELOGENOUS LEUKEMIA WITH B
Page 245 and 246:
DISCUSSION In this study, the use o
Page 247 and 248:
AUTOGRAFTING IN CHRONIC MYELOID LEU
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Table 1 Remission Deaths Graft Hema
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16 (800 mg/m2 per day for two conse
Page 253:
Session XII: CNS
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1.2 Description of the study The tr
Page 258 and 259:
3. Conclusion In conclusion, treatm
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3. Conclusion Hematological toxicit
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Session XIII: Peripheral Stem Cells
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Crouse, 1992). In the present repor
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with no evidence of systemic diseas
Page 270 and 271:
Administration of rhSCF at doses of
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In summary, the ligand for c-kit ha
Page 274 and 275:
AUTOGRAFTING WITH G-CSF-MOBILIZED B
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cells and CD34+ cells observed in t
Page 278 and 279:
6. Brugger W, Bross K, Frisch J, et
Page 280 and 281:
100 -l Collection Efficiency Figure
Page 282 and 283:
MATERIALS AND METHODS PATIENTS. Pat
Page 284 and 285:
None of the patients included in ar
Page 286 and 287:
9. Aurer I, Ribas A, Gale RP. What
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246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
Page 291 and 292:
AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 293 and 294:
SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 295 and 296:
SUMMARY: AUTOLOGOUS MARROW TRANSPLA
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mor. The obverse of this coin is po
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treated at Memorial Hospital in New
Page 301 and 302:
Contributors and Participants Tause
Page 303 and 304:
Leonard Kalman, Hematology/Oncology
Page 305:
D.R. Sutherland, Oncology Research,
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