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( 5 )<br />

lowed by ABMT than refractory disease at the time of ABMT . Surprisingly the<br />

use of TBI and/or purged autografts did not have any impact on outcome. Because<br />

this is a registry analysis, this may also be explained by selection of patients<br />

transplanted.<br />

Because of the natural behaviour of this disease longer follow-up is necessary.<br />

However, we conclude that the data are very promising and warrant a randomized<br />

trial comparing purged vs. unpurged BMT with standard chemotherapy.<br />

The EBMT lymphoma working party has developed this randomized study<br />

in cooperation with transplant centers in Scandinavia, England, France, Germany,<br />

Italy and the Netherlands.<br />

REFERENCES<br />

1. Rohatiner A. et al. <strong>Autologous</strong> bone marrow transplantation. Proceedings of the<br />

Fifth International Symposium: 465-472,1990.<br />

2. Fouillard L. et al. European Journal of Haematology 46: 279-284,1991.<br />

3. Vose J. et al. <strong>Autologous</strong> bone marrow transplantation. Proceedings of the Fifth<br />

International Symposium: 479-485,1990.<br />

4. Freedman A.S. et al. Blood 77:2524-2529,1991.<br />

5. Philip T. et al. New England Journal of Medicine 316:1493-1498,1987.<br />

72<br />

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o<br />

60<br />

a<br />

X<br />

to<br />

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20<br />

(<br />

Figure 1<br />

Low grade lymphoma - progression free survival<br />

h i m i it 11 i<br />

. i i i_<br />

2 4 6 8 10<br />

TIME (YEARS)<br />

N« 79<br />

—1<br />

12<br />

SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION

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