VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

Table 2:
Toxicity of CBP Regimen for 30 Patients with Responding Small
Cell Lung Cancer
# Patients
(n = 30)
Death within 90 days (Candida Sepsis) 2 7
Infectious Complications:
Aspergillus fungal ball 1 Q
Bacterial Sepsis (all central venous line related) 7 23
Clostridia difficile induced diarrhea 4 13
Herpes zoster (within 4-12 months after high
dose therapy) 6 20
Pneumocystis carinii (after steroids) 1 3
Cerebral toxoplasmosis (after steroids) 1 3
Non-hematologic toxicity:
Grade 3 GI bleed during thrombocytopenia 2 7
Interstitial pneumonitis requiring steroids 7 23
Reversible Hemolytic uremic syndrome 1 3
Reversible congestive heart failure 4 13
Reversible Encephalopathy* 1 3
Reversible creatinine 1.5-3.0 mg/dl 8 27
Creatinine > 3.0 mg/dl** 3 10
Ototoxicitv grade 2-3 6 20
Hematologic support:
Marrow given:
Alone 14 47
With Peripheral Blood Progenitor Cells 13 43
With Erythropoietin 3 10
Hematologic toxicity:
Median days duration from marrow
reinfusion to: Median days Range
Granulocytes > 500/ul 21 10-46
Platelets >2 20,000/ul 27 9-49
Platelets > 50,000/ul 35 10-119
Red cell transfusion independence 18 3-43
*received preABMT therapeutic cranial radiotherapy
**reversible in two; the other died of Candida sepsis without recovery
272 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
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