VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

higher frequencies of neurotoxicity and elevated creatinine values as might be
expected. Those patients who received carboplatin had overall higher frequencies
of anemia that required transfusion and thrombocytopenia. Both cDDP and
carboplatin have a role as first-line agents in the treatment of ovarian cancer. The
choice of either cDDP or carboplatin may be determined by the physical condition
of the patient including age, and susceptibility to a particular agenf s toxic
effects. Use of the Calvert formula (14)
may also help to accomplish more optimum
carboplatin dosing in certain patients. There is no published information
available on the efficacy of taxol as a first-line agent in combination with cDDP
or its analogue carboplatin. Recent studies suggest that there is a critical dose
response relationship for taxol. It therefore remains unknown whether and how
taxol will be optimally combined with cDDP or carboplatin in first-line combination
therapy.
Results obtained from certain studies that used cDDP alone or in combination
at a dose of 50 mg/ m 2