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74 Figure 4 Low grade lymphoma - progression free survival Oy purging _U1 I I ' m 4 6 TIME (YEARS) Purged N= 27 CHI = .B280 P = .3629 Not purged N= 54 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
AUTOLOGOUS BONE MARROW TRANSPLANTATION IN 100 CASES OF POOR-PROGNOSIS NON-HODGKIN'S LYMPHOMA. A REPORT OF THE NON-HODGKINS LYMPHOMA CO-OPERATIVE STUDY GROUP (NELCSG). G. Santini, A.M. Congiu, P. Coser, T. Chisesi, R. Sertoli, A. Porcellini, L. Miglio, A. Contu, A.M. Carella, D. Pierluigi, S. Nati, E. Rossi, M. Spriano, R. Vimercati, E. Pungolino, D. Occhini, F. Chimini, V. Vitale, E. Damasio and V. Rizzoli. Division of Haematology I, Ospedale S.Martino, Genoa, Italy. INTRODUCTION Over the last ten years, in spite of the claiming that second and third generation chemotherapy regimens a_4) have improved survival of advanced stage, intermediate or high-grade malignancy non-Hodgkin's lymphoma (NHL)(Groups F-G-H-J/Working Formulation), the percentage of complete remissions obtained (CR) is between 50 to 70%, and about 50% of these patients later relapse. Consequently, the percentage of real cure is about 40% (5-7) . Negative prognostic factors, together with histologic subtype and advanced stage, on the one hand, affect both the possibility of obtaining CR and survival, and, on the other, CR maintenance and disease-free survival(DFS) w- 8 - 13 '. Lymphoblastic lymphoma deserves particular attention. Here, the advanced stage of the lymphoma and adult age of patient play an essential role in the probability of CR maintanance, with a three-year probability of survival and a DFSofabout20% (I4) . Failure to obtain CR, or subsequent relapse, has serious consequences in the course of these lymphomas, because second-line therapies offer poor possibility of salvage 0516 '. Autologous Bone Marrow Transplantation (ABMT) has been seen to overcome resistance, allowing an increase in the dose of available drugs and radiotherapy. Stem cell rescue can shorten the hypoplastic period decreasing lifethreatening risks. Initially used after first-line chemotherapy for relapsed or refractory lymphomas 07 " 191 , ABMT has since been used in more favourable clinical conditions' 20 - 251 ( 2 M 2 ) and finally in first CR . This study reports our experience with poor prognosis NHL patients treated with high dose chemotherapy and/or radiochemotherapy (HDT) followed by ABMT. Results analysis will be evaluated for difference of response and procedure related toxicity in the various groups of treated patients. PATIENTS AND METHODS Up to January 1992,100 adult intermediate or high-grade malignancy NHL were treated with HDT and ABMT rescue. Patients had a median age of 32 years SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 75
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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Session I: Leukemia
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TRIAL PROGRESS The trial opened in
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Table 1. Achievement of Second Remi
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ALLOGENEIC VERSUS AUTOLOGOUS BONE M
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pts). The other 56 pts are too earl
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Figure 1 EORTC-GIMEMA AML 8 A EORTC
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PATIENTS AND METHODS Patients The B
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Thus, as the results of some ongoin
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COMPARISON OF INTENSIVE CONSOLIDATI
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over, 13 pts who had received ICC1
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Session II: Future Directions
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in a previous report 3 . Analysis a
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Engraftment of granulocyte, monocyt
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0.2 - 0.1 - ABMT with mAb purging f
Page 46 and 47: ENHANCED REGENERATION OF NATURAL KI
Page 48 and 49: RESULTS The in vivo immune effects
Page 50 and 51: 16. Rizzoli V, Mangoni L, Carlo-Ste
Page 52 and 53: hydroperoxycyclophosphamide (4HC)-t
Page 54 and 55: survival in patients undergoing ABM
Page 56 and 57: IMMUNOTHERAPY OF AML AFTER ABMT - S
Page 58 and 59: Otherwise toxicity was mild to mode
Page 60 and 61: Therapy. Amsterdam Elsevier 1987;89
Page 62 and 63: 200 IL6 in serum 44 SIXTH INTERNATI
Page 64 and 65: sodes), fewer days of i.v. antibiot
Page 67: Session III: Myeloma
Page 70 and 71: trary, in case of adequate collecti
Page 72 and 73: tion is considered, and all the mor
Page 74 and 75: Table 3: Cost effectiveness of high
Page 77: Session W: Lymphoma
Page 80 and 81: METHODS Selection of patients and t
Page 82 and 83: marrow treatment. Am J Med 85:829,1
Page 84 and 85: HIGH DOSE THERAPY WITH HEMATOPOIETI
Page 86 and 87: in TC 19 medium (Flobio), with an h
Page 88 and 89: progression for a long time after A
Page 90 and 91: Table 2. STATUS AT GRAFT Remission
Page 92 and 93: IL Figura 3 70 SIXTH INTERNATIONAL
Page 94 and 95: ( 5 ) lowed by ABMT than refractory
Page 98 and 99: (range 15-55); 68 males and 32 fema
Page 100 and 101: our experience, this has a seven-ye
Page 102 and 103: 30. Colombat P, Gorin NC, Lemonnier
Page 104 and 105: 82 OVERALL SURUIWL from ABUT (accor
Page 107 and 108: PROGNOSTIC FACTORS IN ADVANCED STAG
Page 109 and 110: REFERENCES 1. Chopra R, Mc Millan A
Page 111 and 112: lished data to attempt to assess th
Page 113 and 114: 1992;10:175-7. 3. McMillan A, Golds
Page 115 and 116: B. DAILY DAY AGENT DOSE -7 -6 -5 -4
Page 117 and 118: cohort with HR treated with BEC-2 i
Page 119 and 120: p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
Page 121 and 122: TABLE 3. TOXICITY BEC TAVe TMJ as 2
Page 123 and 124: ies. 10 Longer blood half-lives hav
Page 125 and 126: agents have been developed cautious
Page 127 and 128: Table 1. Radioisotopes for RIT. Pur
Page 129 and 130: The treatment criterion in this stu
Page 131 and 132: more than 80% of the cases. Patient
Page 133 and 134: Disease Free Survival 800 Time •
Page 135: Session VI: Breast Cancer
Page 138 and 139: achieved a complete remission survi
Page 140 and 141: acil, vincristine, prednisone (CMFV
Page 142 and 143: t: 3 en a in S « J •S •> c ai
Page 144 and 145: LONG TERM FOLLOW UP OF POOR PROGNOS
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tors both for progression-free surv
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222 INDUCTION PHASE ESTROGEN RECEPT
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THE PHARMACOLOGY OF INTENSIVE CYCLO
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PK VARIABILITY OF CPA/CDDP/BCNU Whe
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5. Groshow LB, Piantadosi S, Santos
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- Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
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normal CD34+ progenitor cells
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sequence analysis of the human haem
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Bielefeld, FRG) or control medium w
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3. Koeffler HP, and Golde DW: Chron
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ply infected with supernatants from
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controls must be carefully matched
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Fig. IB: GPI isozyme analysis of 2
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PROCESSING OF STEM CELLS FOR TRANSP
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in progress using marker genes to l
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Table 1. Factors Affecting Quality
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Figure 2 .2 A Refractory/Relapsed L
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HIGH DOSE CHEMOTHERAPY IN GERM CELL
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carboplatin and etoposide with auto
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HIGH DOSE THERAPY IN GERM CELL TUMO
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Confusing data come out from early
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Session Mill: Lung Cancer
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Of the 14 limited stage patients in
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esponses with persistent nodular di
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hanced, detection of initial failur
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Cellules. Bull Cancer 1987;74:587-5
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30 36 42 48 54 60 66 72 78 84 12 18
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Table 2: Toxicity of CBP Regimen fo
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TREATMENT OF NONSMALL CELL LUNG CAN
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Table 1. Combination Chemotherapy R
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Table 6. Hematological Data of the
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ence in survival among the three hi
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Session IX: Ovarian Cancer
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lymph node involvement or parenchym
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higher frequencies of neurotoxicity
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12. Ovarian Cancer Meta-Analysis Pr
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Table 2. Randomized Trials Employin
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BONE MARROW TRANSPLANTATION FOR OVA
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1). Data from the survey was combin
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carboplatinum and ifosfamide. The s
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Session X: Sarcoma
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ated doses in a recent Pediatric On
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cytokines to reduce hospitalization
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TABLE 2 Dose Escalation Schedule Do
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CHRONIC MYELOGENOUS LEUKEMIA WITH B
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DISCUSSION In this study, the use o
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AUTOGRAFTING IN CHRONIC MYELOID LEU
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Table 1 Remission Deaths Graft Hema
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16 (800 mg/m2 per day for two conse
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Session XII: CNS
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1.2 Description of the study The tr
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3. Conclusion In conclusion, treatm
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3. Conclusion Hematological toxicit
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Session XIII: Peripheral Stem Cells
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Crouse, 1992). In the present repor
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with no evidence of systemic diseas
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Administration of rhSCF at doses of
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In summary, the ligand for c-kit ha
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AUTOGRAFTING WITH G-CSF-MOBILIZED B
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cells and CD34+ cells observed in t
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6. Brugger W, Bross K, Frisch J, et
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100 -l Collection Efficiency Figure
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MATERIALS AND METHODS PATIENTS. Pat
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None of the patients included in ar
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9. Aurer I, Ribas A, Gale RP. What
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246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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SUMMARY: AUTOLOGOUS MARROW TRANSPLA
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mor. The obverse of this coin is po
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treated at Memorial Hospital in New
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Contributors and Participants Tause
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Leonard Kalman, Hematology/Oncology
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D.R. Sutherland, Oncology Research,
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