VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

TABLE 2
Dose Escalation Schedule
Dose Level CBDCA1 VP-161 #DLT2/# Treated
1 600 1800 0/3
2 900 1800 1/6
3 1200 1800 0/6
4 1600 1800 4/12
5 2000 1800 2/6
6 2000 2400 2/10
7 2400 2400 3/4 (1 fatality)
8 2175 2400 4/10 (2 fatalities)
1 Dose in mg/M 2
2 DLT = Dose limiting toxicity
Table 2: Schema of dose escalation for the entire group of pediatric solid tumors
and the number of patients with dose limiting toxicity at each level. Dose limiting
toxicity was determined using the NCI clinical toxicity scale.
TABLE 3
SARCOMA RESPONSE DATA
CR PR NR INEV Total
E wing's 4 4 4 0 8/12
Rhabdo 3 1 2 5 4/6
Mise Sarcomas 3 1 2 0 4/6
Osteosarcoma 3 0 1 0 3/4
13 6 9 5 19/28 (68%)
Table 3: Response data given for sarcoma patients only. INEV refers to patients
without measurable disease at the time of transplant.
204 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION