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6. Klein JL, Nguyen TH, Laroque P, et al. Yttrium 90 and Iodine-131 radioimmunoglobulin therapy of an experimental hepatoma. Cancer Res. 1989, 49:63-83. 7. Quadri SM, Vriesendorp HM, Leichner PK, et al. Linker modulated biodistribution of In-Ill and Y-90 labeled MO AB antiferritin immunoconjugates in nude mice and dogs. In: Dicke KA, Armitage JO, Dicke-Evinger MJ, eds. Autologus bone marrow transplantation. Proceedings of the Fifth International Symposium, Omaha, Nebraska, University of Nebraska Medical Center 1991, pp 711-722. 8. Vriesendorp HM, Quadri SM, Williams JK. Radioimmunoglobulin Therapy. In: Armitage JO, Antman KH, eds. High Dose Cancer Therapy. Williams & Wilkins, Baltimore, 1992 pp 84-123. 9. Quadri SM, Lai J, Vriesendorp HM, et al. Evaluation of sterilzed F(ab')2 fragments of monoclonal antiferritin antibody in nude mice model. Antibody Immunoconj. Radiopharm. 1992,5:125 (Abstract). 10. LoBuglio AF, Wheeler RH, Trang J, et al. Mouse/human chimerice monoclonal antibody in man: Kinetics and immune response. Proc. Natl. Acad. Sei. U.S.A. 1989, pp 4220-4224. 11. Meredith RF, Khazaeli MB, Plott WE, et al. Comparison of two mouse/human chimeric antibodies in patients with metastatic colon cancer. Antibody Immunoconj. Radiopharm. 1992,5:75-80. 12. Vriesendorp HM. Prediction of effects of therapeutic total body irrdiation. Radiât. Oncol. 1990,18: (Suppl 1), 37-50. 13. Fritz TE, Norris WP, Tolle VP, et al. Relationship of dose rate and total dose to responses of continuously irradiated beagles. In: Late biological effects of ionizing radiation. Vol. 2. IAEA-SM-2241 /206. Vienna International Atomic Energy Agency 1978, pp 71-83. 14. Bierman PJ, Vose JM, Leichner PK, et al. Yttrium-90 labeled antiferritin followed by high dose chemotherapy and autologous bone marrow transplantation for poor prognosis Hodgkin's disease. J. Clin. Oncol. 1993 (in press). 102 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
Table 1. Radioisotopes for RIT. Purpose Isotope Tl/2 Beta max Gamma (days) (MeV) (MeV) diagnosis technetium-99 ml 0.25 - 0.140 dosimetry Indium-Ill 2.8 - 0.173-0.247 Iodine-123 0.54 - 0.159 diagnosis Copper-67 2.4 0.57 0.184 dosimetry Rhenium-186 3.8 1.07 0.137 therapy Rhenium-188 0.7 2.12 0.155 *Nickel-66 2.9 0.20 — therapy Yttrium-90 2.7 2.27 — * for adjuvant RIT onlv. Table 2. Sequential Study Phases for Radioimmunoglobulin Therapy Agents. Phase Study Aim 0 Preclinical analysis 1 In vivo stability in human patients tumor targeting in human patients 2A Optimize therapeutic ratio in human patients Tumor dosimetry Human Toxicology 2B Radioactivity escalation in human patients 3 Randomized Trial RIT vs "old" therapy 4 Incorporation into multimodality treatment Note: Delay of toxicology and escalation studies until therapeutic radio of RLT has been optimized. Biodistribution and pharmacokinetic studies are much easier to perform for RIT than for chemotherapy. They allow for the conservation of selectivity of RIT and decrease the side effects experienced by patients in "classical" chemotherapy phase 1 and 2 studies. SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 103
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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Session I: Leukemia
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TRIAL PROGRESS The trial opened in
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Table 1. Achievement of Second Remi
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ALLOGENEIC VERSUS AUTOLOGOUS BONE M
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pts). The other 56 pts are too earl
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Figure 1 EORTC-GIMEMA AML 8 A EORTC
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PATIENTS AND METHODS Patients The B
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Thus, as the results of some ongoin
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COMPARISON OF INTENSIVE CONSOLIDATI
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over, 13 pts who had received ICC1
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Session II: Future Directions
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in a previous report 3 . Analysis a
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Engraftment of granulocyte, monocyt
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0.2 - 0.1 - ABMT with mAb purging f
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ENHANCED REGENERATION OF NATURAL KI
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RESULTS The in vivo immune effects
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16. Rizzoli V, Mangoni L, Carlo-Ste
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hydroperoxycyclophosphamide (4HC)-t
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survival in patients undergoing ABM
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IMMUNOTHERAPY OF AML AFTER ABMT - S
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Otherwise toxicity was mild to mode
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Therapy. Amsterdam Elsevier 1987;89
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200 IL6 in serum 44 SIXTH INTERNATI
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sodes), fewer days of i.v. antibiot
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Session III: Myeloma
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trary, in case of adequate collecti
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tion is considered, and all the mor
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Table 3: Cost effectiveness of high
Page 77: Session W: Lymphoma
Page 80 and 81: METHODS Selection of patients and t
Page 82 and 83: marrow treatment. Am J Med 85:829,1
Page 84 and 85: HIGH DOSE THERAPY WITH HEMATOPOIETI
Page 86 and 87: in TC 19 medium (Flobio), with an h
Page 88 and 89: progression for a long time after A
Page 90 and 91: Table 2. STATUS AT GRAFT Remission
Page 92 and 93: IL Figura 3 70 SIXTH INTERNATIONAL
Page 94 and 95: ( 5 ) lowed by ABMT than refractory
Page 96 and 97: 74 Figure 4 Low grade lymphoma - pr
Page 98 and 99: (range 15-55); 68 males and 32 fema
Page 100 and 101: our experience, this has a seven-ye
Page 102 and 103: 30. Colombat P, Gorin NC, Lemonnier
Page 104 and 105: 82 OVERALL SURUIWL from ABUT (accor
Page 107 and 108: PROGNOSTIC FACTORS IN ADVANCED STAG
Page 109 and 110: REFERENCES 1. Chopra R, Mc Millan A
Page 111 and 112: lished data to attempt to assess th
Page 113 and 114: 1992;10:175-7. 3. McMillan A, Golds
Page 115 and 116: B. DAILY DAY AGENT DOSE -7 -6 -5 -4
Page 117 and 118: cohort with HR treated with BEC-2 i
Page 119 and 120: p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
Page 121 and 122: TABLE 3. TOXICITY BEC TAVe TMJ as 2
Page 123 and 124: ies. 10 Longer blood half-lives hav
Page 125: agents have been developed cautious
Page 129 and 130: The treatment criterion in this stu
Page 131 and 132: more than 80% of the cases. Patient
Page 133 and 134: Disease Free Survival 800 Time •
Page 135: Session VI: Breast Cancer
Page 138 and 139: achieved a complete remission survi
Page 140 and 141: acil, vincristine, prednisone (CMFV
Page 142 and 143: t: 3 en a in S « J •S •> c ai
Page 144 and 145: LONG TERM FOLLOW UP OF POOR PROGNOS
Page 146 and 147: tors both for progression-free surv
Page 148 and 149: 222 INDUCTION PHASE ESTROGEN RECEPT
Page 150 and 151: THE PHARMACOLOGY OF INTENSIVE CYCLO
Page 152 and 153: PK VARIABILITY OF CPA/CDDP/BCNU Whe
Page 154 and 155: 5. Groshow LB, Piantadosi S, Santos
Page 157 and 158: - Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
Page 159 and 160: normal CD34+ progenitor cells
Page 161 and 162: sequence analysis of the human haem
Page 163 and 164: Bielefeld, FRG) or control medium w
Page 165 and 166: 3. Koeffler HP, and Golde DW: Chron
Page 167 and 168: ply infected with supernatants from
Page 169 and 170: controls must be carefully matched
Page 171 and 172: Fig. IB: GPI isozyme analysis of 2
Page 173 and 174: PROCESSING OF STEM CELLS FOR TRANSP
Page 175 and 176: in progress using marker genes to l
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Table 1. Factors Affecting Quality
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Figure 2 .2 A Refractory/Relapsed L
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HIGH DOSE CHEMOTHERAPY IN GERM CELL
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carboplatin and etoposide with auto
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HIGH DOSE THERAPY IN GERM CELL TUMO
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Confusing data come out from early
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Session Mill: Lung Cancer
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Of the 14 limited stage patients in
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esponses with persistent nodular di
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hanced, detection of initial failur
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Cellules. Bull Cancer 1987;74:587-5
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30 36 42 48 54 60 66 72 78 84 12 18
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Table 2: Toxicity of CBP Regimen fo
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TREATMENT OF NONSMALL CELL LUNG CAN
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Table 1. Combination Chemotherapy R
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Table 6. Hematological Data of the
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ence in survival among the three hi
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Session IX: Ovarian Cancer
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lymph node involvement or parenchym
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higher frequencies of neurotoxicity
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12. Ovarian Cancer Meta-Analysis Pr
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Table 2. Randomized Trials Employin
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BONE MARROW TRANSPLANTATION FOR OVA
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1). Data from the survey was combin
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carboplatinum and ifosfamide. The s
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Session X: Sarcoma
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ated doses in a recent Pediatric On
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cytokines to reduce hospitalization
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TABLE 2 Dose Escalation Schedule Do
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CHRONIC MYELOGENOUS LEUKEMIA WITH B
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DISCUSSION In this study, the use o
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AUTOGRAFTING IN CHRONIC MYELOID LEU
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Table 1 Remission Deaths Graft Hema
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16 (800 mg/m2 per day for two conse
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Session XII: CNS
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1.2 Description of the study The tr
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3. Conclusion In conclusion, treatm
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3. Conclusion Hematological toxicit
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Session XIII: Peripheral Stem Cells
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Crouse, 1992). In the present repor
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with no evidence of systemic diseas
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Administration of rhSCF at doses of
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In summary, the ligand for c-kit ha
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AUTOGRAFTING WITH G-CSF-MOBILIZED B
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cells and CD34+ cells observed in t
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6. Brugger W, Bross K, Frisch J, et
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100 -l Collection Efficiency Figure
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MATERIALS AND METHODS PATIENTS. Pat
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None of the patients included in ar
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9. Aurer I, Ribas A, Gale RP. What
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246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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SUMMARY: AUTOLOGOUS MARROW TRANSPLA
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mor. The obverse of this coin is po
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treated at Memorial Hospital in New
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Contributors and Participants Tause
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Leonard Kalman, Hematology/Oncology
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D.R. Sutherland, Oncology Research,
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