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3. Conclusion Hematological toxicity, in particular thrombopenia, is the major toxicity of HDF in these patients. The hematological toxicity is greater than that observed after high dose BCNU in the same patients. Extra hematological toxicity is mild, especially the liver toxicity. No lung toxicity was observed. Patients receiving more than 700mg/m2 in 2 days (>350mg/m2/d) experienced in more than 50% of the cases a severe gastric pain. The duration of hospitalization after HDF is higher than after HD BCNU in our experience but remains acceptable. The dose of 900mg/m2 of fotemustin in 2 days followed by ABMT is the maximum tolerable dose of this agent in single drug high dose therapy. In this phase I-II trial, the response rate to HDF in high grade glioma was not found different to that reported in a previous report with conventional dose (7). A phase II trial of HDF at the dose of 900mg/m2 in high grade glioma is ongoing in our institution. REFERENCES: 1. Takvorian T, Parker LM, Hochberg FH, et al: Autologous bone marrow transplantation: host effect of high dose BCNU. 1:610-620,1983. 2. Phillips GL, Wolff SN, Fay JW et al. Intensive BCNU chemotherapy and autologous bone marrow transplantation for malignant glioma. J.Clin. Oncol. 4:639-645,1986. 3. Wolff SN, Phillips GL, Herzig GP. High dose BCNU with autologous bone marrow transplantation for the adjuvant treatment of high grade gliomas of the central nervous system. Cancer Treat. Rep. 71:183-185,1987. 4. Mbidde EK, Selby PJ, Perren TJ et al. High dose BCNU chemotherapy with autologous bone marrow transplantation and full dose radiotherapy for grade IV astrocytoma. Br.J.Cancer 58:779-792,1988. 5. Johnson DB, Thompson TM, Corwin JA et al. Prolongation of survival for high grade malignant gliomas with adjuvant high dose BCNU and autologous bone marrow transplantation. Br.J.Cancer 58:779-792,1988. 6. Biron P, Vial C, Chauvin F et al. Strategy including surgery, high dose BCNU followed by AABMT and radiotherapy in supratentorial high grade astrocytomas: a report on 98 patients, in Autologous bone marrow transplantation. Dicke KA, Armitage JA, MJ Dicke-Evinger. The University of Nebraska Medical Center 1991; pp 637-646. 7. Frenay M, Giroux B, Khoury S, et al. Phase II study of fotemustin in recurrent supratentorial malignant glioma. Eur. J.Cancer 27:852-856,1991. 220 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
Table 1: Extrahematological toxicity of high dose fotemustin in patients with high grade gliomas. WHOSCORE NE 0 1 2 3 4 Nausea / vomiting 0 1 8 14 2 0 Venous 0 23 1 1 0 0 Fever 0 19 1 4 1 0 Hepatic gamma GT 1 0 6 9 7 2 ALT 1 11 10 0 2 1 Renal 1 21 3 0 0 0 Conciousness deterioration 0 23 1 0 0 1 L 3 GLIOMAS - HD FOTEMUSTINE OVERALL SURVIVAL msOtsn - 10 months -Ml pot lents N- 2S P« OX CLS BJOBtstistica Unit 23/11/93 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 221
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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Session I: Leukemia
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TRIAL PROGRESS The trial opened in
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Table 1. Achievement of Second Remi
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ALLOGENEIC VERSUS AUTOLOGOUS BONE M
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pts). The other 56 pts are too earl
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Figure 1 EORTC-GIMEMA AML 8 A EORTC
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PATIENTS AND METHODS Patients The B
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Thus, as the results of some ongoin
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COMPARISON OF INTENSIVE CONSOLIDATI
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over, 13 pts who had received ICC1
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Session II: Future Directions
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in a previous report 3 . Analysis a
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Engraftment of granulocyte, monocyt
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0.2 - 0.1 - ABMT with mAb purging f
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ENHANCED REGENERATION OF NATURAL KI
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RESULTS The in vivo immune effects
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16. Rizzoli V, Mangoni L, Carlo-Ste
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hydroperoxycyclophosphamide (4HC)-t
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survival in patients undergoing ABM
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IMMUNOTHERAPY OF AML AFTER ABMT - S
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Otherwise toxicity was mild to mode
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Therapy. Amsterdam Elsevier 1987;89
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200 IL6 in serum 44 SIXTH INTERNATI
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sodes), fewer days of i.v. antibiot
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Session III: Myeloma
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trary, in case of adequate collecti
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tion is considered, and all the mor
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Table 3: Cost effectiveness of high
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Session W: Lymphoma
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METHODS Selection of patients and t
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marrow treatment. Am J Med 85:829,1
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HIGH DOSE THERAPY WITH HEMATOPOIETI
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in TC 19 medium (Flobio), with an h
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progression for a long time after A
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Table 2. STATUS AT GRAFT Remission
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IL Figura 3 70 SIXTH INTERNATIONAL
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( 5 ) lowed by ABMT than refractory
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74 Figure 4 Low grade lymphoma - pr
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(range 15-55); 68 males and 32 fema
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our experience, this has a seven-ye
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30. Colombat P, Gorin NC, Lemonnier
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82 OVERALL SURUIWL from ABUT (accor
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PROGNOSTIC FACTORS IN ADVANCED STAG
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REFERENCES 1. Chopra R, Mc Millan A
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lished data to attempt to assess th
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1992;10:175-7. 3. McMillan A, Golds
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B. DAILY DAY AGENT DOSE -7 -6 -5 -4
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cohort with HR treated with BEC-2 i
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p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
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TABLE 3. TOXICITY BEC TAVe TMJ as 2
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ies. 10 Longer blood half-lives hav
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agents have been developed cautious
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Table 1. Radioisotopes for RIT. Pur
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The treatment criterion in this stu
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more than 80% of the cases. Patient
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Disease Free Survival 800 Time •
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Session VI: Breast Cancer
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achieved a complete remission survi
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acil, vincristine, prednisone (CMFV
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t: 3 en a in S « J •S •> c ai
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LONG TERM FOLLOW UP OF POOR PROGNOS
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tors both for progression-free surv
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222 INDUCTION PHASE ESTROGEN RECEPT
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THE PHARMACOLOGY OF INTENSIVE CYCLO
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PK VARIABILITY OF CPA/CDDP/BCNU Whe
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5. Groshow LB, Piantadosi S, Santos
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- Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
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normal CD34+ progenitor cells
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sequence analysis of the human haem
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Bielefeld, FRG) or control medium w
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3. Koeffler HP, and Golde DW: Chron
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ply infected with supernatants from
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controls must be carefully matched
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Fig. IB: GPI isozyme analysis of 2
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PROCESSING OF STEM CELLS FOR TRANSP
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in progress using marker genes to l
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Table 1. Factors Affecting Quality
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Figure 2 .2 A Refractory/Relapsed L
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HIGH DOSE CHEMOTHERAPY IN GERM CELL
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carboplatin and etoposide with auto
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HIGH DOSE THERAPY IN GERM CELL TUMO
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Confusing data come out from early
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Session Mill: Lung Cancer
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Of the 14 limited stage patients in
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esponses with persistent nodular di
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hanced, detection of initial failur
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Cellules. Bull Cancer 1987;74:587-5
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30 36 42 48 54 60 66 72 78 84 12 18
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Table 2: Toxicity of CBP Regimen fo
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TREATMENT OF NONSMALL CELL LUNG CAN
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Table 1. Combination Chemotherapy R
Page 210 and 211: Table 6. Hematological Data of the
Page 212 and 213: ence in survival among the three hi
Page 215: Session IX: Ovarian Cancer
Page 218 and 219: lymph node involvement or parenchym
Page 220 and 221: higher frequencies of neurotoxicity
Page 222 and 223: 12. Ovarian Cancer Meta-Analysis Pr
Page 224 and 225: Table 2. Randomized Trials Employin
Page 226 and 227: BONE MARROW TRANSPLANTATION FOR OVA
Page 228 and 229: 1). Data from the survey was combin
Page 230 and 231: carboplatinum and ifosfamide. The s
Page 233: Session X: Sarcoma
Page 236 and 237: ated doses in a recent Pediatric On
Page 238 and 239: cytokines to reduce hospitalization
Page 240 and 241: TABLE 2 Dose Escalation Schedule Do
Page 243 and 244: CHRONIC MYELOGENOUS LEUKEMIA WITH B
Page 245 and 246: DISCUSSION In this study, the use o
Page 247 and 248: AUTOGRAFTING IN CHRONIC MYELOID LEU
Page 249 and 250: Table 1 Remission Deaths Graft Hema
Page 251 and 252: 16 (800 mg/m2 per day for two conse
Page 253: Session XII: CNS
Page 256 and 257: 1.2 Description of the study The tr
Page 258 and 259: 3. Conclusion In conclusion, treatm
Page 263: Session XIII: Peripheral Stem Cells
Page 266 and 267: Crouse, 1992). In the present repor
Page 268 and 269: with no evidence of systemic diseas
Page 270 and 271: Administration of rhSCF at doses of
Page 272 and 273: In summary, the ligand for c-kit ha
Page 274 and 275: AUTOGRAFTING WITH G-CSF-MOBILIZED B
Page 276 and 277: cells and CD34+ cells observed in t
Page 278 and 279: 6. Brugger W, Bross K, Frisch J, et
Page 280 and 281: 100 -l Collection Efficiency Figure
Page 282 and 283: MATERIALS AND METHODS PATIENTS. Pat
Page 284 and 285: None of the patients included in ar
Page 286 and 287: 9. Aurer I, Ribas A, Gale RP. What
Page 288 and 289: 246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
Page 291 and 292: AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 293 and 294: SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 295 and 296: SUMMARY: AUTOLOGOUS MARROW TRANSPLA
Page 297 and 298: mor. The obverse of this coin is po
Page 299 and 300: treated at Memorial Hospital in New
Page 301 and 302: Contributors and Participants Tause
Page 303 and 304: Leonard Kalman, Hematology/Oncology
Page 305: D.R. Sutherland, Oncology Research,
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