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Cellules. Bull Cancer 1987;74:587-595. 25. Warde P, Payne D. Does Thoracic Irradiation Improve Survival and Local Control in Limited-Stage Small-Cell Carcinoma of the Lung? A Meta-Analysis. J Clin Oncol 1992; 10: 890-895. 26. Arriagada R, Kramar A, Le Chevalier T, De Cremoux H. Competing Events Determining Relapse-Free survival in Limited Small-Cell Lung Carcinoma. J Clin Oncol 1992; 10: 447-451. 27. Perry MC, Eaton WL, Propert KJ, et al. Chemotherapy with or without Radiation Therapy in Limited Small-Cell Carcinoma of the Lung. New Engl J Med 1987;316:912-918. 28. Bunn PA, Lichter AS, Makuch RW, et al. Chemotherapy Alone or Chemotherapy with Chest Radiation Therapy in Limited Stage Small Cell Lung Cancer. Ann Int Med 1987;106:655-662. 29. Kies MS, Mira JG, Crowley JJ, et al. Multimodal Therapy for Limited Small-Cell Lung Cancer: A Randomized Study of Induction Combination Chemotherapy with or without Thoracic Radiation in Complete Responders; and with Wide-Field versus Reduced-Field Radiation in Partial Responders: A Southwest Oncology Group Study. J Clin Oncol 1987;5:592-600. 30. McCracken JD, Janaki LM, Crowley JJ, et al. Concurrent Chemotherapy/Radiotherapy for Limited Small-Cell Lung Carcinoma: A Southwest Oncology Group Study. J Clin Oncol 1990;8:892-898. 31. Turrisi AT, Glover DJ, Mason BA. A Preliminary Report: Concurrent Twice-Daily Radiotherapy Plus Platinum-Etoposide chemotherapy for Limited Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 1988;15:183-187. 32. Turrisi A, Wagner H, Glover D, et al. Limited Small Cell Lung Cancer: Concurrent BID Thoracic Radiotherapy with Platinum-Etoposide: An ECOG Study. Proc ASCO 1990;9:230 (C-887). 33. Johnson DH, Turrisi AT, Chang AY, et al. Alternating Chemotherapy and Thoracic Radiotherapy in Limited Small Cell Lung Cancer: A Test of the Looney Hypothesis. Proc ASCO 1991;10:243 (C-829). 33. Peters WP, Eder JP, Henner WD, et al. High-dose combination alkylating agents with autologous marrow support: A phase I trial. J Clin Oncol 1986; 4: 646-654. 34. Frei E III, Antman K, Teicher B, et al. Bone marrow autotransplantation for solid tumors — prospects. J Clin Oncol 1989; 7: 515-526. 35. Nemunaitis J, Rabinowe SN, Singer JW, et al. Recombinant granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid malignancy: Pooled results from three randomized double-blind, placebo controlled trials. New Engl J Med 1991;324:1773-1778. 36. Elias AD, Ayash L, Anderson K, et al. GM-CSF-stimulated peripheral stem cells in hematopoietic support in breast cancer. Blood 1992; 79: 3036-3044. 368 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
Induction Chemotherapy to Maximum Response: Partial (PR), Near Complete (>90% PR), or Complete Response (CR) I Intensification Drugs Total Dose (me/m2) -8 -7 Day From Marrow Reinfusion -6 -5 -4 -3 -2 -1 0 Cyclophosphamide Cisplatin Carmustine 5625 165 480 X XX X XX X XX XX Marrow Harvest T Reinfusion *Marrow with or without peripheral blood progenitor cells i Restage 4 Chest and Cranial Radiotherapy (to begin after pulmonary function tests stable) 4* 50-56 Gy/5-6 weeks thoracic radiation 30 Gy/3 weeks cranial radiation Involved field radiation to normal tissue tolerance (Radiotherapy may be given before or after ABMT) Figure 1: Schema of High dose therapy for patients with limited or extensive SCLC SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 169
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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Session I: Leukemia
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TRIAL PROGRESS The trial opened in
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Table 1. Achievement of Second Remi
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ALLOGENEIC VERSUS AUTOLOGOUS BONE M
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pts). The other 56 pts are too earl
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Figure 1 EORTC-GIMEMA AML 8 A EORTC
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PATIENTS AND METHODS Patients The B
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Thus, as the results of some ongoin
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COMPARISON OF INTENSIVE CONSOLIDATI
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over, 13 pts who had received ICC1
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Session II: Future Directions
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in a previous report 3 . Analysis a
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Engraftment of granulocyte, monocyt
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0.2 - 0.1 - ABMT with mAb purging f
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ENHANCED REGENERATION OF NATURAL KI
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RESULTS The in vivo immune effects
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16. Rizzoli V, Mangoni L, Carlo-Ste
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hydroperoxycyclophosphamide (4HC)-t
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survival in patients undergoing ABM
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IMMUNOTHERAPY OF AML AFTER ABMT - S
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Otherwise toxicity was mild to mode
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Therapy. Amsterdam Elsevier 1987;89
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200 IL6 in serum 44 SIXTH INTERNATI
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sodes), fewer days of i.v. antibiot
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Session III: Myeloma
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trary, in case of adequate collecti
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tion is considered, and all the mor
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Table 3: Cost effectiveness of high
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Session W: Lymphoma
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METHODS Selection of patients and t
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marrow treatment. Am J Med 85:829,1
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HIGH DOSE THERAPY WITH HEMATOPOIETI
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in TC 19 medium (Flobio), with an h
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progression for a long time after A
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Table 2. STATUS AT GRAFT Remission
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IL Figura 3 70 SIXTH INTERNATIONAL
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( 5 ) lowed by ABMT than refractory
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74 Figure 4 Low grade lymphoma - pr
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(range 15-55); 68 males and 32 fema
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our experience, this has a seven-ye
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30. Colombat P, Gorin NC, Lemonnier
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82 OVERALL SURUIWL from ABUT (accor
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PROGNOSTIC FACTORS IN ADVANCED STAG
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REFERENCES 1. Chopra R, Mc Millan A
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lished data to attempt to assess th
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1992;10:175-7. 3. McMillan A, Golds
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B. DAILY DAY AGENT DOSE -7 -6 -5 -4
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cohort with HR treated with BEC-2 i
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p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
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TABLE 3. TOXICITY BEC TAVe TMJ as 2
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ies. 10 Longer blood half-lives hav
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agents have been developed cautious
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Table 1. Radioisotopes for RIT. Pur
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The treatment criterion in this stu
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more than 80% of the cases. Patient
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Disease Free Survival 800 Time •
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Session VI: Breast Cancer
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achieved a complete remission survi
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acil, vincristine, prednisone (CMFV
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t: 3 en a in S « J •S •> c ai
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LONG TERM FOLLOW UP OF POOR PROGNOS
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tors both for progression-free surv
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222 INDUCTION PHASE ESTROGEN RECEPT
Page 150 and 151: THE PHARMACOLOGY OF INTENSIVE CYCLO
Page 152 and 153: PK VARIABILITY OF CPA/CDDP/BCNU Whe
Page 154 and 155: 5. Groshow LB, Piantadosi S, Santos
Page 157 and 158: - Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
Page 159 and 160: normal CD34+ progenitor cells
Page 161 and 162: sequence analysis of the human haem
Page 163 and 164: Bielefeld, FRG) or control medium w
Page 165 and 166: 3. Koeffler HP, and Golde DW: Chron
Page 167 and 168: ply infected with supernatants from
Page 169 and 170: controls must be carefully matched
Page 171 and 172: Fig. IB: GPI isozyme analysis of 2
Page 173 and 174: PROCESSING OF STEM CELLS FOR TRANSP
Page 175 and 176: in progress using marker genes to l
Page 177 and 178: Table 1. Factors Affecting Quality
Page 179: Figure 2 .2 A Refractory/Relapsed L
Page 183 and 184: HIGH DOSE CHEMOTHERAPY IN GERM CELL
Page 185 and 186: carboplatin and etoposide with auto
Page 187 and 188: HIGH DOSE THERAPY IN GERM CELL TUMO
Page 189 and 190: Confusing data come out from early
Page 191: Session Mill: Lung Cancer
Page 194 and 195: Of the 14 limited stage patients in
Page 196 and 197: esponses with persistent nodular di
Page 198 and 199: hanced, detection of initial failur
Page 202 and 203: 30 36 42 48 54 60 66 72 78 84 12 18
Page 204 and 205: Table 2: Toxicity of CBP Regimen fo
Page 206 and 207: TREATMENT OF NONSMALL CELL LUNG CAN
Page 208 and 209: Table 1. Combination Chemotherapy R
Page 210 and 211: Table 6. Hematological Data of the
Page 212 and 213: ence in survival among the three hi
Page 215: Session IX: Ovarian Cancer
Page 218 and 219: lymph node involvement or parenchym
Page 220 and 221: higher frequencies of neurotoxicity
Page 222 and 223: 12. Ovarian Cancer Meta-Analysis Pr
Page 224 and 225: Table 2. Randomized Trials Employin
Page 226 and 227: BONE MARROW TRANSPLANTATION FOR OVA
Page 228 and 229: 1). Data from the survey was combin
Page 230 and 231: carboplatinum and ifosfamide. The s
Page 233: Session X: Sarcoma
Page 236 and 237: ated doses in a recent Pediatric On
Page 238 and 239: cytokines to reduce hospitalization
Page 240 and 241: TABLE 2 Dose Escalation Schedule Do
Page 243 and 244: CHRONIC MYELOGENOUS LEUKEMIA WITH B
Page 245 and 246: DISCUSSION In this study, the use o
Page 247 and 248: AUTOGRAFTING IN CHRONIC MYELOID LEU
Page 249 and 250: Table 1 Remission Deaths Graft Hema
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16 (800 mg/m2 per day for two conse
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Session XII: CNS
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1.2 Description of the study The tr
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3. Conclusion In conclusion, treatm
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3. Conclusion Hematological toxicit
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Session XIII: Peripheral Stem Cells
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Crouse, 1992). In the present repor
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with no evidence of systemic diseas
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Administration of rhSCF at doses of
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In summary, the ligand for c-kit ha
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AUTOGRAFTING WITH G-CSF-MOBILIZED B
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cells and CD34+ cells observed in t
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6. Brugger W, Bross K, Frisch J, et
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100 -l Collection Efficiency Figure
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MATERIALS AND METHODS PATIENTS. Pat
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None of the patients included in ar
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9. Aurer I, Ribas A, Gale RP. What
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246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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SUMMARY: AUTOLOGOUS MARROW TRANSPLA
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mor. The obverse of this coin is po
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treated at Memorial Hospital in New
Page 301 and 302:
Contributors and Participants Tause
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Leonard Kalman, Hematology/Oncology
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D.R. Sutherland, Oncology Research,
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