VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

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9. Aurer I, Ribas A, Gale RP. What is the role of recombinant colony stimulating factors in bone marrow transplantation? Bone Marrow Transplantation 1990,6,79-87. 10. Socinski MA, Elias A, Schnipper L et al. Granulocyte-macrophage colony stimulating factor expends the circulating progenitor cell compartment in man. Lancet 1988, i, 1194-1198. 11. Gianni AM, Sienna S, Bregni M et al. Granulocyte-macrophage colony stimulating factor to harvest haemopoietic stem cells for autotransplantation. Lancet 1989, ii, 581584. 12. Lorhman HP, Schremi W, Lang et al. Changes of granulopoiesis during and after adjuvant chemotherapy for breast cancer. Br J Haematol 1978,40,369-381. 13. Richman CM, Weiner RS, Yankee RA. Increase in circulating stem cells following chemotherapy in man. Blood 1976,47,1031-1039. 14. Tilly H, Vannier JP, Jean P et al. Daily evaluation of circulating granulocyte-macrophage progenitors during bone marrow recovery from induction therapy in acute leukemia. Leuk Res 1986,10,353-356. 15. To LB, Haylock DN, Kimber RJ et al. High levels of circulating haemopoietic stem cells in very early remission from acute non lymphoblastic leukaemia and their collection and cryopreservation. Br J Haematol 1984,58,399-410. Table 1. Patient Characteristics (Patients grafted in brackets) all patients arm A arm B P n 21 (17) 16 (13) 5(4) age (median) 16-67 (36) 16-67 (36) 26-55 (42) 0.57 sex M/F 19/2 (15/2) 15/1 (12/1) 4/1 (3/1) 0.42 Hodgkin's disease 8(7) 6(5) 2(2) low grade NHL 8(7) 6(5) 2(2) 0.97 high grade NHL 5(3) 4(3) 1(0) marrow involvement 10 (8) 8(6) 2(2) 1.0 at diagnosis Marrow involvement 8(6) 5(3) 3(3) 0.32 at relapse previous extended 5(3) 4(3) 1(0) 1.0 field radiotherapy BEFORE MINE REGIMEN (median) (median) (median) HGB level g/1 100-134 (121) 100-134 (122) 103-122 (117) 0.12 PMN (giga/1) 2.0-10.5 (4.4) 2.0-10.5 (4.5) 2.6-5.0 (3.8) 0.58 platelets (giga/1) 141-741 (300) 160-741 (335) 141-400 (183) 0.19 CONDITIONING REGIMEN TBI/Cy 6 4 2 0.58 BEAM 11 9 2 244 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
Table 2. PBSC harvest. arm A arm 6 P duration of aplasia after "MINE" CT 0-10 7-13 0.04* (days) median 6 median 12 nadir PMN after "MINE" CT (109/1) 0.01-1.45 0.01-0.24 0.4 (0.39) (0.14) # CFU-GM in the peripheral blood 4-848 0-164 0.06 before CT (pre-test) (211) (41) exposure to GM-CSF before starting 4-6 5 cytapheresis (days) median 10 time to 1st cytapheresis after CT 7-28 30-36 (days) median 15 median 35 # cytapheresis 2-5 3-4 0.32 # nucleated cells collected (108/kg) 5.63±8.91 4.86±9.03 0.64 # nucleated cells/cytapheresis 1.63±2.9 1.33±2.6 0.71 (108/kg) # CFU-GM collected (104/kg) 6.51±14.89 3.21±6.43 0.28 # CFU-GM/cytapheresis (104/kg) 1.79±3.48 0.92±1.21 0.45 arm A Figure 1 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 245
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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Session I: Leukemia
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TRIAL PROGRESS The trial opened in
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Table 1. Achievement of Second Remi
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ALLOGENEIC VERSUS AUTOLOGOUS BONE M
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pts). The other 56 pts are too earl
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Figure 1 EORTC-GIMEMA AML 8 A EORTC
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PATIENTS AND METHODS Patients The B
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Thus, as the results of some ongoin
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COMPARISON OF INTENSIVE CONSOLIDATI
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over, 13 pts who had received ICC1
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Session II: Future Directions
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in a previous report 3 . Analysis a
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Engraftment of granulocyte, monocyt
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0.2 - 0.1 - ABMT with mAb purging f
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ENHANCED REGENERATION OF NATURAL KI
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RESULTS The in vivo immune effects
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16. Rizzoli V, Mangoni L, Carlo-Ste
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hydroperoxycyclophosphamide (4HC)-t
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survival in patients undergoing ABM
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IMMUNOTHERAPY OF AML AFTER ABMT - S
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Otherwise toxicity was mild to mode
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Therapy. Amsterdam Elsevier 1987;89
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200 IL6 in serum 44 SIXTH INTERNATI
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sodes), fewer days of i.v. antibiot
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Session III: Myeloma
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trary, in case of adequate collecti
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tion is considered, and all the mor
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Table 3: Cost effectiveness of high
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Session W: Lymphoma
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METHODS Selection of patients and t
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marrow treatment. Am J Med 85:829,1
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HIGH DOSE THERAPY WITH HEMATOPOIETI
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in TC 19 medium (Flobio), with an h
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progression for a long time after A
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Table 2. STATUS AT GRAFT Remission
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IL Figura 3 70 SIXTH INTERNATIONAL
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( 5 ) lowed by ABMT than refractory
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74 Figure 4 Low grade lymphoma - pr
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(range 15-55); 68 males and 32 fema
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our experience, this has a seven-ye
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30. Colombat P, Gorin NC, Lemonnier
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82 OVERALL SURUIWL from ABUT (accor
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PROGNOSTIC FACTORS IN ADVANCED STAG
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REFERENCES 1. Chopra R, Mc Millan A
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lished data to attempt to assess th
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1992;10:175-7. 3. McMillan A, Golds
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B. DAILY DAY AGENT DOSE -7 -6 -5 -4
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cohort with HR treated with BEC-2 i
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p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
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TABLE 3. TOXICITY BEC TAVe TMJ as 2
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ies. 10 Longer blood half-lives hav
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agents have been developed cautious
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Table 1. Radioisotopes for RIT. Pur
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The treatment criterion in this stu
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more than 80% of the cases. Patient
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Disease Free Survival 800 Time •
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Session VI: Breast Cancer
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achieved a complete remission survi
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acil, vincristine, prednisone (CMFV
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t: 3 en a in S « J •S •> c ai
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LONG TERM FOLLOW UP OF POOR PROGNOS
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tors both for progression-free surv
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222 INDUCTION PHASE ESTROGEN RECEPT
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THE PHARMACOLOGY OF INTENSIVE CYCLO
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PK VARIABILITY OF CPA/CDDP/BCNU Whe
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5. Groshow LB, Piantadosi S, Santos
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- Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
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normal CD34+ progenitor cells
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sequence analysis of the human haem
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Bielefeld, FRG) or control medium w
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3. Koeffler HP, and Golde DW: Chron
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ply infected with supernatants from
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controls must be carefully matched
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Fig. IB: GPI isozyme analysis of 2
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PROCESSING OF STEM CELLS FOR TRANSP
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in progress using marker genes to l
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Table 1. Factors Affecting Quality
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Figure 2 .2 A Refractory/Relapsed L
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HIGH DOSE CHEMOTHERAPY IN GERM CELL
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carboplatin and etoposide with auto
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HIGH DOSE THERAPY IN GERM CELL TUMO
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Confusing data come out from early
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Session Mill: Lung Cancer
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Of the 14 limited stage patients in
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esponses with persistent nodular di
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hanced, detection of initial failur
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Cellules. Bull Cancer 1987;74:587-5
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30 36 42 48 54 60 66 72 78 84 12 18
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Table 2: Toxicity of CBP Regimen fo
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TREATMENT OF NONSMALL CELL LUNG CAN
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Table 1. Combination Chemotherapy R
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Table 6. Hematological Data of the
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ence in survival among the three hi
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Session IX: Ovarian Cancer
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lymph node involvement or parenchym
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higher frequencies of neurotoxicity
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12. Ovarian Cancer Meta-Analysis Pr
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Table 2. Randomized Trials Employin
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BONE MARROW TRANSPLANTATION FOR OVA
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1). Data from the survey was combin
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carboplatinum and ifosfamide. The s
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Session X: Sarcoma
Page 236 and 237: ated doses in a recent Pediatric On
Page 238 and 239: cytokines to reduce hospitalization
Page 240 and 241: TABLE 2 Dose Escalation Schedule Do
Page 243 and 244: CHRONIC MYELOGENOUS LEUKEMIA WITH B
Page 245 and 246: DISCUSSION In this study, the use o
Page 247 and 248: AUTOGRAFTING IN CHRONIC MYELOID LEU
Page 249 and 250: Table 1 Remission Deaths Graft Hema
Page 251 and 252: 16 (800 mg/m2 per day for two conse
Page 253: Session XII: CNS
Page 256 and 257: 1.2 Description of the study The tr
Page 258 and 259: 3. Conclusion In conclusion, treatm
Page 260 and 261: 3. Conclusion Hematological toxicit
Page 263: Session XIII: Peripheral Stem Cells
Page 266 and 267: Crouse, 1992). In the present repor
Page 268 and 269: with no evidence of systemic diseas
Page 270 and 271: Administration of rhSCF at doses of
Page 272 and 273: In summary, the ligand for c-kit ha
Page 274 and 275: AUTOGRAFTING WITH G-CSF-MOBILIZED B
Page 276 and 277: cells and CD34+ cells observed in t
Page 278 and 279: 6. Brugger W, Bross K, Frisch J, et
Page 280 and 281: 100 -l Collection Efficiency Figure
Page 282 and 283: MATERIALS AND METHODS PATIENTS. Pat
Page 284 and 285: None of the patients included in ar
Page 288 and 289: 246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
Page 291 and 292: AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 293 and 294: SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 295 and 296: SUMMARY: AUTOLOGOUS MARROW TRANSPLA
Page 297 and 298: mor. The obverse of this coin is po
Page 299 and 300: treated at Memorial Hospital in New
Page 301 and 302: Contributors and Participants Tause
Page 303 and 304: Leonard Kalman, Hematology/Oncology
Page 305: D.R. Sutherland, Oncology Research,
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