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VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

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RESULTS<br />

The in vivo immune effects triggered by in vitro mafosfamide purging were<br />

evaluated in 6 patients with AML, 3 with ALL, and 3 with NHL (NHL-Pur)<br />

grafted with marrow purged at adjusted dose. In addition, 3 NHL patients<br />

grafted with unpurged marrow (NHL-Unpur) were studied. The mean (+SD)<br />

pre-transplant values of spontaneous NK activity were 32 + 22%, 9 + 7%, 21 +<br />

8%, and 33 ± 25% for AML, ALL, NHL-Pur, and NHL-Unpur, respectively. The<br />

post-transplant behavior of NK activity was not homogeneous for the different<br />

subgroups of patients. In AML patients, NK activity reached pre-transplant<br />

value (41 + 15%, P

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