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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
- Page 15: Session I: Leukemia
- Page 18 and 19: TRIAL PROGRESS The trial opened in
- Page 20 and 21: Table 1. Achievement of Second Remi
- Page 22 and 23: ALLOGENEIC VERSUS AUTOLOGOUS BONE M
- Page 24 and 25: pts). The other 56 pts are too earl
- Page 26 and 27: Figure 1 EORTC-GIMEMA AML 8 A EORTC
- Page 28 and 29: PATIENTS AND METHODS Patients The B
- Page 30 and 31: Thus, as the results of some ongoin
- Page 32 and 33: COMPARISON OF INTENSIVE CONSOLIDATI
- Page 34 and 35: over, 13 pts who had received ICC1
- Page 37: Session II: Future Directions
- Page 40 and 41: in a previous report 3 . Analysis a
- Page 42 and 43: Engraftment of granulocyte, monocyt
- Page 44 and 45: 0.2 - 0.1 - ABMT with mAb purging f
- Page 46 and 47: ENHANCED REGENERATION OF NATURAL KI
- Page 48 and 49: RESULTS The in vivo immune effects
- Page 50 and 51: 16. Rizzoli V, Mangoni L, Carlo-Ste
- Page 52 and 53: hydroperoxycyclophosphamide (4HC)-t
- Page 54 and 55: survival in patients undergoing ABM
- Page 56 and 57: IMMUNOTHERAPY OF AML AFTER ABMT - S
- Page 58 and 59: Otherwise toxicity was mild to mode
- Page 60 and 61: Therapy. Amsterdam Elsevier 1987;89
- Page 62 and 63: 200 IL6 in serum 44 SIXTH INTERNATI
- Page 64 and 65: sodes), fewer days of i.v. antibiot
- Page 69 and 70: PERIPHERAL BLOOD STEM CELL TRANSPLA
- Page 71 and 72: plant; two others died of intercurr
- Page 73 and 74: Table 1: Cox Model Parameters 1983
- Page 75: Table 5: Patient's quality of life
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- Page 81 and 82: cal remission, 28 patients had no r
- Page 83 and 84: o PRIOR CR 1 1 1 1 , 1 0 20 40 60 8
- Page 85 and 86: ized in table 1. There were 21 male
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- Page 89 and 90: TABLE 1. PATIENT CHARACTERISTICS No
- Page 91 and 92: Figure 1 ^ years SIXTH INTERNATIONA
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- Page 95 and 96: Figure 2 Low grade lymphoma - progr
- Page 97 and 98: AUTOLOGOUS BONE MARROW TRANSPLANTAT
- Page 99 and 100: RESULTS AND TOXICITY In all cases t
- Page 101 and 102: Med 104:757-765,1986. 11. Velasquez
- Page 103 and 104: Table 2. Histology According to the
- Page 105: Session V: Hodgkin's
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- Page 110 and 111: HODGKIN'S DISEASE: AUTOLOGOUS BMT F
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MARROW TRANSPLANTATION AFTER MARROW
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(Table 2). Patients receiving ThioT
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TABLE 2. PATIENT CHARACTERISTICS #
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RADIOIMMUNOTHERAPY FOR BONE MARROW
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PATIENT SELECTION RIT is in a devel
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6. Klein JL, Nguyen TH, Laroque P,
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HIGH DOSE INTERCALATOR BASED THERAP
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throughout their hospital stay and
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cytosine arabinoside in refractory
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Table 1. Patient Characteristics No
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RESULTS WITH CONVENTIONAL DOSE CHEM
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ined modality therapy that included
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X * G à E i s ¡8 1 ¡1 if o 2 3 k
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3 C/5 < < < < O < I Z2ZZ N 2 ^J^ini
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Intensive hydration to maintain hig
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10. Spitzer G, Farha P, Valdivieso
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47 94 142 189 Weeks 236 283 Figure
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agents are given intermittently in
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PD CORRELATES OF PK MEASUREMENTS. B
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Evening Session
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CD34 antibodies are removed by glyc
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glycoprotein half-life, etc) of the
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SELECTION OF PH-NEGATIVE PROGENITOR
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culture, CFU-GM growth was signific
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TRANSDUCTION AND EXPRESSION OF THE
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and were infected five times over a
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DNA from human nucleated cells. Nuc
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O 600 Fig. 3A: Transduction of CD34
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AUTOLOGOUS STEM CELL HARVEST AND EV
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tration of 5% DMSO, 4% albumin and
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Table 3. Prognostic factors in pred
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Session VII: Testicular
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completion of conventional salvage
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treatment of poor risk non seminoma
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TOXICITY Mean time to PMN count >50
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TABLE 1: PATIENTS' CHARACTERISTICS
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INTENSIVE COMBINED MODALITY THERAPY
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chest and upper abdominal computeri
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nosed by fine needle aspirate, pres
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Soc, Series A. 1972; 135:185-198. 8
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Induction Chemotherapy to Maximum R
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Table 1: Characteristics of 30 Pati
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Table 3: SITES OF RELAPSE N Relapse
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marrow support with or without peri
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Table 4. Resulte of VP-16/Platlnol
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HIGH DOSE RADIOTHERAPY FOR NON-SMAL
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mens that incorporate biological pr
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CONVENTIONAL TREATMENT RESULTS IN E
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suits of treatment remain unsatisfa
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platelet support. This drug combina
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Table 1. Operative Staging of Ovari
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Table 3. Response Complete response
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Higher dose carboplatin with marrow
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leukemia, Hodgkin's and non-Hodgkin
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transplantation for refractory soli
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HIGH DOSE CHEMOTHERAPY AND AUTOLOGO
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graphies are given in Table 1. In a
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VP-16 CBDCA CYTOXAN DAY SCHEMA FOR
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Session XI: CML
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Busulfan (4mg/kg/day 4 days) and hi
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6. Reiffers J, Trouette R, Marit G,
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RESULTS Hematological recovery to >
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AUTOLOGOUS PHILADELPHIA (PH) CHROMO
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stage. However, the clinical result
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HIGH DOSE NITROSUREA FOLLOWED BY AB
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Lung complications were observed 22
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eceived 800mg/m 2 . 7 patients rece
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Table 1: Extrahematological toxicit
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INFLUENCE OF MINIMAL TUMOR CONTAMIN
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patients. Not surprisingly the PSCT
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THE RECOMBINANT HUMAN LIGAND FOR C-
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a significant increase in the numbe
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15. Molineux G, Pojda Z, et al: A c
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It was the objective of our study t
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Interestingly, patients autografted
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CR/PR Relapse 1—1 Chemotherapy Tr
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EFFECTS OF TWO SCHEDULES OF ADMINIS
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cells because of the bad haematolog
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sion in this arm. The evolution of
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Table 2. PBSC harvest. arm A arm 6
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Summaries
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R. Harousseau reviewed the results
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- as far as relapses are concerned:
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PHASE III STUDIES There are a very
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INDICATIONS FOR AUTOLOGOUS BONE MAR
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ies of ASCT in first complete remis
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Karel A. Dicke, Arlington Cancer Ce
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Chris Poynton, Department of Hemato