VI Autologous Bone Marrow Transplantation.pdf - Blog Science ...

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sodes), fewer days of i.v. antibiotics (24 vs 27 days) and shortened initial hospitalization (27 vs 33 days), but it did not decrease the number of days with fever. In all the studies performed in the BMT setting, G-CSF was well tolerated and accelerated neutrophil recovery. Moreover it has been shown that in standard cancer chemotherapy G-CSF not only enhanced neutrophil recovery, but, as compared with the placebo group, also clearly reduced days with fever >38° C. We analyzed data on 8 patients with high-grade non-Hodgkin's lymphoma (NHL) and 17 patients with Hodgkin's disease (HD), who were treated with G- CSF following autologous bone marrow transplantation (Tab I). Patients were conditioned with BEAM (NHL) or CVB (HD 15 patients); two patients with HD and bone marrow involvement had peripheral blood stem cells collected and were then conditioned with BEAM. G-CSF was started at the dose of 5 mg/kg body weight, i.v. by 1 hr daily infusion, from day +1 to day +20, following infusion of the autologous bone marrow at day 0. Overall the mean time to ANC >500 x 10 9 /L was 9 days (range 5-15) for patients with HD and 14 days (range 10-21) for NHL, and it took a mean time of 14 days to achieve an ANC of 1.0 x 10 9 /L (Tab. II). Patients had fewer and shorter febrile episodes (average 3 days with fever>38°C) and fewer days of i.v. antibiotics compared with historical controls. (Table III). According to our results and from experimental work, the early use of G- CSF is fully justified. As to infection, there is a response, both through activation of the immune system, and by increasing the production of neutrophils. Perhaps it is not coincidental that G-CSF, together, perhaps with IL-6 that increases Ig secretion by B cell, are also capable of stem cell interaction. At a dose of 5 mg/ kg, G-CSF was very well tolerated and appeared to have activity when compared with a comparable retrospective control group, by reducing the neutropenia which follows cytotoxic chemotherapy. References 1) Mizoguchi et al. Exp Hematol. 10:874,1982. 2) Metcalf and Nicola J. Cell Physiol. 116:198,1983. 3) Ikebuchi K Clark SC et al. Proc Natl. Acad. Sci. USA 85:445,1988. 4) Moore MAS. Blood 80:1,1992. 5) Nemunaitis J. et al. New Eng. J. Med. 324:1773,1991. 46 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
Table 1. G-CSF in ABMT: Patient Characteristics Disease HD NHL No. Patients 17* 8 M/F 9/8 3/5 Age (mean) 25 28 Status RC 3 4 RP - 2 AR 14 2 *2PBSC Table 2. frCSF in ABMT: ANC Recovery Disease No. Patients ANC ANC ANC >100 >500 >1000 HD 17* 5(3-12) 9(5-15-) 10(7-21) NHL 8 11(9-16) 14(10-21) 16(12-23) CONTROLS Nemanaitis 86 16(8-41) 25(10-60) 29(17-64) Sheridan 16 - 20 29 Taylor 58 18(7-34) 22(10-51) 30(14-61) *2PBSCT Table 3. G-CSF in ABMT: Incidence of Infection Disease No. Patients No. of days Bacteremic Days of IV fever >38°C episodes antibiotic HD 17 15 4 14(5-32) NHL 8 4 2 14(9-21) CONTROLS Nemunaitis 86 12(0-30) - - Sheridan 18 9 - 18 Taylor 58 7 19 - SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION 47
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 15: Session I: Leukemia
Page 18 and 19: TRIAL PROGRESS The trial opened in
Page 20 and 21: Table 1. Achievement of Second Remi
Page 22 and 23: ALLOGENEIC VERSUS AUTOLOGOUS BONE M
Page 24 and 25: pts). The other 56 pts are too earl
Page 26 and 27: Figure 1 EORTC-GIMEMA AML 8 A EORTC
Page 28 and 29: PATIENTS AND METHODS Patients The B
Page 30 and 31: Thus, as the results of some ongoin
Page 32 and 33: COMPARISON OF INTENSIVE CONSOLIDATI
Page 34 and 35: over, 13 pts who had received ICC1
Page 37: Session II: Future Directions
Page 40 and 41: in a previous report 3 . Analysis a
Page 42 and 43: Engraftment of granulocyte, monocyt
Page 44 and 45: 0.2 - 0.1 - ABMT with mAb purging f
Page 46 and 47: ENHANCED REGENERATION OF NATURAL KI
Page 48 and 49: RESULTS The in vivo immune effects
Page 50 and 51: 16. Rizzoli V, Mangoni L, Carlo-Ste
Page 52 and 53: hydroperoxycyclophosphamide (4HC)-t
Page 54 and 55: survival in patients undergoing ABM
Page 56 and 57: IMMUNOTHERAPY OF AML AFTER ABMT - S
Page 58 and 59: Otherwise toxicity was mild to mode
Page 60 and 61: Therapy. Amsterdam Elsevier 1987;89
Page 62 and 63: 200 IL6 in serum 44 SIXTH INTERNATI
Page 67: Session III: Myeloma
Page 70 and 71: trary, in case of adequate collecti
Page 72 and 73: tion is considered, and all the mor
Page 74 and 75: Table 3: Cost effectiveness of high
Page 77: Session W: Lymphoma
Page 80 and 81: METHODS Selection of patients and t
Page 82 and 83: marrow treatment. Am J Med 85:829,1
Page 84 and 85: HIGH DOSE THERAPY WITH HEMATOPOIETI
Page 86 and 87: in TC 19 medium (Flobio), with an h
Page 88 and 89: progression for a long time after A
Page 90 and 91: Table 2. STATUS AT GRAFT Remission
Page 92 and 93: IL Figura 3 70 SIXTH INTERNATIONAL
Page 94 and 95: ( 5 ) lowed by ABMT than refractory
Page 96 and 97: 74 Figure 4 Low grade lymphoma - pr
Page 98 and 99: (range 15-55); 68 males and 32 fema
Page 100 and 101: our experience, this has a seven-ye
Page 102 and 103: 30. Colombat P, Gorin NC, Lemonnier
Page 104 and 105: 82 OVERALL SURUIWL from ABUT (accor
Page 107 and 108: PROGNOSTIC FACTORS IN ADVANCED STAG
Page 109 and 110: REFERENCES 1. Chopra R, Mc Millan A
Page 111 and 112: lished data to attempt to assess th
Page 113 and 114: 1992;10:175-7. 3. McMillan A, Golds
Page 115 and 116:
B. DAILY DAY AGENT DOSE -7 -6 -5 -4
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cohort with HR treated with BEC-2 i
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p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
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TABLE 3. TOXICITY BEC TAVe TMJ as 2
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ies. 10 Longer blood half-lives hav
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agents have been developed cautious
Page 127 and 128:
Table 1. Radioisotopes for RIT. Pur
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The treatment criterion in this stu
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more than 80% of the cases. Patient
Page 133 and 134:
Disease Free Survival 800 Time •
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Session VI: Breast Cancer
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achieved a complete remission survi
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acil, vincristine, prednisone (CMFV
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t: 3 en a in S « J •S •> c ai
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LONG TERM FOLLOW UP OF POOR PROGNOS
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tors both for progression-free surv
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222 INDUCTION PHASE ESTROGEN RECEPT
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THE PHARMACOLOGY OF INTENSIVE CYCLO
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PK VARIABILITY OF CPA/CDDP/BCNU Whe
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5. Groshow LB, Piantadosi S, Santos
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- Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
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normal CD34+ progenitor cells
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sequence analysis of the human haem
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Bielefeld, FRG) or control medium w
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3. Koeffler HP, and Golde DW: Chron
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ply infected with supernatants from
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controls must be carefully matched
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Fig. IB: GPI isozyme analysis of 2
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PROCESSING OF STEM CELLS FOR TRANSP
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in progress using marker genes to l
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Table 1. Factors Affecting Quality
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Figure 2 .2 A Refractory/Relapsed L
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HIGH DOSE CHEMOTHERAPY IN GERM CELL
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carboplatin and etoposide with auto
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HIGH DOSE THERAPY IN GERM CELL TUMO
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Confusing data come out from early
Page 191:
Session Mill: Lung Cancer
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Of the 14 limited stage patients in
Page 196 and 197:
esponses with persistent nodular di
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hanced, detection of initial failur
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Cellules. Bull Cancer 1987;74:587-5
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30 36 42 48 54 60 66 72 78 84 12 18
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Table 2: Toxicity of CBP Regimen fo
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TREATMENT OF NONSMALL CELL LUNG CAN
Page 208 and 209:
Table 1. Combination Chemotherapy R
Page 210 and 211:
Table 6. Hematological Data of the
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ence in survival among the three hi
Page 215:
Session IX: Ovarian Cancer
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lymph node involvement or parenchym
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higher frequencies of neurotoxicity
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12. Ovarian Cancer Meta-Analysis Pr
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Table 2. Randomized Trials Employin
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BONE MARROW TRANSPLANTATION FOR OVA
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1). Data from the survey was combin
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carboplatinum and ifosfamide. The s
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Session X: Sarcoma
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ated doses in a recent Pediatric On
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cytokines to reduce hospitalization
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TABLE 2 Dose Escalation Schedule Do
Page 243 and 244:
CHRONIC MYELOGENOUS LEUKEMIA WITH B
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DISCUSSION In this study, the use o
Page 247 and 248:
AUTOGRAFTING IN CHRONIC MYELOID LEU
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Table 1 Remission Deaths Graft Hema
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16 (800 mg/m2 per day for two conse
Page 253:
Session XII: CNS
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1.2 Description of the study The tr
Page 258 and 259:
3. Conclusion In conclusion, treatm
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3. Conclusion Hematological toxicit
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Session XIII: Peripheral Stem Cells
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Crouse, 1992). In the present repor
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with no evidence of systemic diseas
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Administration of rhSCF at doses of
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In summary, the ligand for c-kit ha
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AUTOGRAFTING WITH G-CSF-MOBILIZED B
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cells and CD34+ cells observed in t
Page 278 and 279:
6. Brugger W, Bross K, Frisch J, et
Page 280 and 281:
100 -l Collection Efficiency Figure
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MATERIALS AND METHODS PATIENTS. Pat
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None of the patients included in ar
Page 286 and 287:
9. Aurer I, Ribas A, Gale RP. What
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246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
Page 291 and 292:
AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 293 and 294:
SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 295 and 296:
SUMMARY: AUTOLOGOUS MARROW TRANSPLA
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mor. The obverse of this coin is po
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treated at Memorial Hospital in New
Page 301 and 302:
Contributors and Participants Tause
Page 303 and 304:
Leonard Kalman, Hematology/Oncology
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D.R. Sutherland, Oncology Research,
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