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ies of ASCT in first complete remission of Hodgkin's disease patients, the results seen in these 15 high-risk patients are considerably better than those observed in patients with such poor prognostic features (21 patients have been up to now inserted in Genoa: 19/21 alive and well at a median of 4 years!). Such a strategy will concentrate the toxicity of ABMT on an appropriate group of patients and maximize the antineoplastic effects of the conditioning regimen by utilizing such intensification before a refractory disease status develops and before additional and ineffective conventional salvage treatment adds to the risk of eventual toxicity. The results of many teams suggest that patients who never responded to conventional therapy and are completely refractory to chemotherapy are also bad candidates for ABMT and should be spared this aggressive procedure and relative toxicity. The finding of an increased death rate in heavily pretreated patients with Hodgkin's disease emphasizes the need not to postpone the ABMT too long. On the contrary, recent use of ABMT in lymphoblastic lymphoma in first CR demonstrated usefulness for survival and, overall, the death-rate was far lower. Therefore, we feel that ABMT when employed in first CR should probably be the treatment of choice for patients with disseminated HD who achieve CR after first line therapy; moreover by reducing the BCNU dose and with the use of hemopoietic growth factors (G-CSF or GM-CSF) we could avoid the risks of interstitial pneumonitis and of prolonged neutropenia. A phase III study comparing ABMT vs no further therapy in patients with high risk HD in first CR could finally provide substantial arguments to the possible role of ABMT in HD. In this way an international trial has been recently organized. 256 SIXTH INTERNATIONAL SYMPOSIUM ON AUTOLOGOUS BONE MARROW TRANSPLANTATION
Contributors and Participants Tauseef Ahmed, New York Medical College, Valhalla, New York 10595. Borje Andersson, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030. Robert Andrews, Fred Hutchinson Cancer Center, 1124 Columbia St. Seattle, Washington 98104. Alfred Bahnson, University of Pittsburgh, E1651 Biomedical <strong>Science</strong> Tower, Pittsburgh, Pennsylvania 15261. William J. Baker, Department of Hematology/Oncology, Brooke Army Medical Center, Fort Sam Houston, Texas 78234. Richard Baltz, 17200 Red Oak Suite 212, Houston, Texas 77090 Michael Barnett, Vancouver General Hospital, 910 W. 10th Avenue, Vancouver, British Columbia V5Z4E3, Canada. Neil Barth, 4000 W. Pacific Coast Highway, Suite 3C, Newport Beach, California 92663. Ronald Berenson, Cellpro, Inc., 22322 20th Ave. SE, Suite 100, Bothell, Washington 98021. Didier Blaise, Institut Paoli Calmettes, 232 Blvd. De Ste Marguerite, 13273, Marseile, Cedex 9, France. Jean Yves Blay, Centre Leon Berard, 28, Rue Laennec, 69373 Lynon Cedex 8, France. George Blumenschein, Arlington Cancer Center, 906 W. Randol Mill Rd., Arlington, Texas 76012. Daniela Brovedani, Via Acerbi 10-22, 16148 Genoa, Italy. Alan K. Burnett, University of Wales, College of Medicine, Health Park, Cardiff CF44XN, UK Alessandro Busca, Dept. of Pediatrics, University of Turin, PSSZ. Polonia 94, 10126 Tornino, Italy. Angelo Michèle Carella, Via Acerbi 10-22, 16148 Genoa, Italy. Carmello Carlo-Stella, Cattedra Di Ematologia, Universita Di Parma, Via Gramsci 14, 1-43100 Parma, Italy. Steven W. Corso, 5606 Castleknight, San Antonio, Texas 78218. Albert Deisseroth, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., MDAH Box 55, Houston, Texas 77030
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Autologous Bone Marrow Transplantat
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CONTENTS nviAum TMLHTA'I OTT! 7 A l
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AUTOLOGOUS BONE MARROW TRANSPLANTAT
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TREATMENT OF NONSMALL CELL LUNG CAN
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SUMMARY OF THE NON HODGKIN LYMPHOMA
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Session I: Leukemia
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TRIAL PROGRESS The trial opened in
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Table 1. Achievement of Second Remi
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ALLOGENEIC VERSUS AUTOLOGOUS BONE M
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pts). The other 56 pts are too earl
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Figure 1 EORTC-GIMEMA AML 8 A EORTC
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PATIENTS AND METHODS Patients The B
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Thus, as the results of some ongoin
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COMPARISON OF INTENSIVE CONSOLIDATI
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over, 13 pts who had received ICC1
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Session II: Future Directions
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in a previous report 3 . Analysis a
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Engraftment of granulocyte, monocyt
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0.2 - 0.1 - ABMT with mAb purging f
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ENHANCED REGENERATION OF NATURAL KI
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RESULTS The in vivo immune effects
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16. Rizzoli V, Mangoni L, Carlo-Ste
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hydroperoxycyclophosphamide (4HC)-t
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survival in patients undergoing ABM
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IMMUNOTHERAPY OF AML AFTER ABMT - S
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Otherwise toxicity was mild to mode
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Therapy. Amsterdam Elsevier 1987;89
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200 IL6 in serum 44 SIXTH INTERNATI
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sodes), fewer days of i.v. antibiot
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Session III: Myeloma
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trary, in case of adequate collecti
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tion is considered, and all the mor
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Table 3: Cost effectiveness of high
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Session W: Lymphoma
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METHODS Selection of patients and t
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marrow treatment. Am J Med 85:829,1
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HIGH DOSE THERAPY WITH HEMATOPOIETI
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in TC 19 medium (Flobio), with an h
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progression for a long time after A
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Table 2. STATUS AT GRAFT Remission
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IL Figura 3 70 SIXTH INTERNATIONAL
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( 5 ) lowed by ABMT than refractory
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74 Figure 4 Low grade lymphoma - pr
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(range 15-55); 68 males and 32 fema
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our experience, this has a seven-ye
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30. Colombat P, Gorin NC, Lemonnier
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82 OVERALL SURUIWL from ABUT (accor
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PROGNOSTIC FACTORS IN ADVANCED STAG
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REFERENCES 1. Chopra R, Mc Millan A
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lished data to attempt to assess th
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1992;10:175-7. 3. McMillan A, Golds
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B. DAILY DAY AGENT DOSE -7 -6 -5 -4
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cohort with HR treated with BEC-2 i
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p R 0 P O R T I 0 N 1 0.9 0.8 0.7 0
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TABLE 3. TOXICITY BEC TAVe TMJ as 2
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ies. 10 Longer blood half-lives hav
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agents have been developed cautious
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Table 1. Radioisotopes for RIT. Pur
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The treatment criterion in this stu
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more than 80% of the cases. Patient
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Disease Free Survival 800 Time •
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Session VI: Breast Cancer
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achieved a complete remission survi
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acil, vincristine, prednisone (CMFV
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t: 3 en a in S « J •S •> c ai
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LONG TERM FOLLOW UP OF POOR PROGNOS
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tors both for progression-free surv
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222 INDUCTION PHASE ESTROGEN RECEPT
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THE PHARMACOLOGY OF INTENSIVE CYCLO
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PK VARIABILITY OF CPA/CDDP/BCNU Whe
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5. Groshow LB, Piantadosi S, Santos
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- Tn'üTiifi'.m'jii.'yjKJiHtyiwiT T
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normal CD34+ progenitor cells
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sequence analysis of the human haem
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Bielefeld, FRG) or control medium w
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3. Koeffler HP, and Golde DW: Chron
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ply infected with supernatants from
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controls must be carefully matched
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Fig. IB: GPI isozyme analysis of 2
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PROCESSING OF STEM CELLS FOR TRANSP
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in progress using marker genes to l
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Table 1. Factors Affecting Quality
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Figure 2 .2 A Refractory/Relapsed L
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HIGH DOSE CHEMOTHERAPY IN GERM CELL
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carboplatin and etoposide with auto
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HIGH DOSE THERAPY IN GERM CELL TUMO
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Confusing data come out from early
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Session Mill: Lung Cancer
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Of the 14 limited stage patients in
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esponses with persistent nodular di
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hanced, detection of initial failur
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Cellules. Bull Cancer 1987;74:587-5
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30 36 42 48 54 60 66 72 78 84 12 18
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Table 2: Toxicity of CBP Regimen fo
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TREATMENT OF NONSMALL CELL LUNG CAN
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Table 1. Combination Chemotherapy R
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Table 6. Hematological Data of the
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ence in survival among the three hi
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Session IX: Ovarian Cancer
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lymph node involvement or parenchym
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higher frequencies of neurotoxicity
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12. Ovarian Cancer Meta-Analysis Pr
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Table 2. Randomized Trials Employin
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BONE MARROW TRANSPLANTATION FOR OVA
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1). Data from the survey was combin
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carboplatinum and ifosfamide. The s
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Session X: Sarcoma
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ated doses in a recent Pediatric On
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cytokines to reduce hospitalization
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TABLE 2 Dose Escalation Schedule Do
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CHRONIC MYELOGENOUS LEUKEMIA WITH B
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DISCUSSION In this study, the use o
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AUTOGRAFTING IN CHRONIC MYELOID LEU
Page 249 and 250: Table 1 Remission Deaths Graft Hema
Page 251 and 252: 16 (800 mg/m2 per day for two conse
Page 253: Session XII: CNS
Page 256 and 257: 1.2 Description of the study The tr
Page 258 and 259: 3. Conclusion In conclusion, treatm
Page 260 and 261: 3. Conclusion Hematological toxicit
Page 263: Session XIII: Peripheral Stem Cells
Page 266 and 267: Crouse, 1992). In the present repor
Page 268 and 269: with no evidence of systemic diseas
Page 270 and 271: Administration of rhSCF at doses of
Page 272 and 273: In summary, the ligand for c-kit ha
Page 274 and 275: AUTOGRAFTING WITH G-CSF-MOBILIZED B
Page 276 and 277: cells and CD34+ cells observed in t
Page 278 and 279: 6. Brugger W, Bross K, Frisch J, et
Page 280 and 281: 100 -l Collection Efficiency Figure
Page 282 and 283: MATERIALS AND METHODS PATIENTS. Pat
Page 284 and 285: None of the patients included in ar
Page 286 and 287: 9. Aurer I, Ribas A, Gale RP. What
Page 288 and 289: 246 o 0.6 b 0.1 B1 Figure 2 p = 0.0
Page 291 and 292: AUTOLOGOUS BONE MARROW TRANSPLANTAT
Page 293 and 294: SUMMARY OF THE NON HODGKIN LYMPHOMA
Page 295 and 296: SUMMARY: AUTOLOGOUS MARROW TRANSPLA
Page 297 and 298: mor. The obverse of this coin is po
Page 299: treated at Memorial Hospital in New
Page 303 and 304: Leonard Kalman, Hematology/Oncology
Page 305: D.R. Sutherland, Oncology Research,
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