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Normalized Cell Cell Index Cell Index Index<br />
5<br />
Cells in Real-Time!<br />
5<br />
4<br />
5<br />
4<br />
3<br />
4<br />
3<br />
2<br />
3 Seed<br />
2 Cells<br />
1 Seed<br />
2 Cells<br />
1 Seed<br />
0 Cells<br />
1<br />
0<br />
0<br />
Cells in Real-Time!<br />
Treatment<br />
Treatment<br />
Treatment<br />
20 40 60<br />
Control<br />
12.5 Control µM Etoposide<br />
12.5 Control 25 µM Etoposide<br />
12.5 25 µM Etoposide<br />
25 µM Etoposide<br />
50 µM Etoposide<br />
100 50 µM Etoposide<br />
100 50 µM Etoposide 80<br />
0<br />
0<br />
20 Time 40 (hours) 60 100 µM Etoposide 80<br />
0 20 Time 40 (hours)<br />
Time (hours)<br />
60 80<br />
www.roche-applied-science.com<br />
www.roche-applied-science.com<br />
www.roche-applied-science.com<br />
xCELLigence Real-Time<br />
xCELLigence Real-Time<br />
xCELLigence Cell Analyzer Real-Time System<br />
Cell Analyzer System<br />
Cell Analyzer System<br />
Discover<br />
what<br />
you’ve<br />
been<br />
missing<br />
Cells in Real-Time!<br />
Figure 1: Real-time monitoring of cytotoxicity<br />
Figure through 1: DNA Real-time damage. monitoring Etoposide of is cytotoxicity<br />
a DNA damaging<br />
Figure through agent which 1: DNA Real-time induces damage. apoptosis monitoring Etoposide in high of is cytotoxicity<br />
a concentrations,<br />
DNA damaging<br />
through agent while at which lower DNA induces concentrations damage. apoptosis Etoposide it in leads high is a to concentrations,<br />
DNA S-Phase damaging and/or<br />
agent while G2 arrest. at which lower induces concentrations apoptosis it in leads high to concentrations,<br />
S-Phase and/or<br />
while G2 arrest. at lower concentrations it leads to S-Phase and/or<br />
G2 arrest.<br />
XCELLIGENCE is a trademark of Roche.<br />
© 2009 Roche Diagnostics GmbH. All rights reserved.<br />
XCELLIGENCE is a trademark of Roche.<br />
© 2009 Roche Diagnostics GmbH. All rights reserved.<br />
XCELLIGENCE is a trademark of Roche.<br />
© 2009 Roche Diagnostics GmbH. All rights reserved.<br />
Besuchen Sie uns<br />
Besuchen Sie uns<br />
Besuchen Sie uns<br />
auf der Biotechnica<br />
auf der Biotechnica<br />
auf der Biotechnica<br />
vom 6.-8. Oktober 2009<br />
vom 6.-8. Oktober 2009<br />
vom 6.-8. Oktober 2009<br />
in Halle 9 am Stand C11<br />
in Halle 9 am Stand C11<br />
in Halle 9 am Stand C11<br />
Experience the power of dynamic, Real-Time, non-invasive cellular<br />
Experience analysis with the the power xCELLigence of dynamic, System Real-Time, from Roche non-invasive Applied cellular Science.<br />
Experience analysis with the the power xCELLigence of dynamic, System Real-Time, from Roche non-invasive Applied cellular Science.<br />
analysis Acquire with data that the xCELLigence end-point analysis System could from never Roche realize, Applied throughout Science.<br />
Acquire your entire data experiment. that end-point Choose analysis between could 3×16, never 96- realize, or 6×96 throughout well<br />
Acquire your data that end-point analysis could never realize, throughout<br />
microtiter entire plate experiment. formats. Choose between 3×16, 96- or 6×96 well<br />
your microtiter entire plate experiment. formats. Choose between 3×16, 96- or 6×96 well<br />
microtiter � Just add plate cells: formats. Obtain physiologically relevant data without labels and<br />
� Just<br />
�<br />
reporters.<br />
add cells: Obtain physiologically relevant data without labels and<br />
Just<br />
reporters.<br />
add cells: Obtain physiologically relevant data without labels and<br />
� reporters. Don’t miss any effect: Capture online data throughout the entire<br />
� Don’t miss any effect: Capture online data throughout the entire<br />
�<br />
experiment.<br />
Don’t<br />
experiment.<br />
miss any effect: Capture online data throughout the entire<br />
� experiment. Maximize versatility: Detect cells across a broad dynamic range and<br />
� Maximize versatility: Detect cells across a broad dynamic range and<br />
�<br />
perform a wide variety of applications.<br />
Maximize<br />
perform a wide<br />
versatility:<br />
variety of<br />
Detect<br />
applications.<br />
cells across a broad dynamic range and<br />
(e.g., proliferation and cytotoxicity, Figure 1)<br />
perform<br />
(e.g., proliferation<br />
a wide variety<br />
and cytotoxicity,<br />
of applications.<br />
Figure 1)<br />
� (e.g., Analyze proliferation Cell Migration and cytotoxicity, and Invasion Figure with 1) a special<br />
� Analyze Cell Migration and Invasion with a special NEW<br />
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chamber for the 3×16 well format<br />
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or<br />
For contact more your information, local Roche visit representative www.xcelligence.roche.com today!<br />
or<br />
contact your local Roche representative today!<br />
Roche Diagnostics GmbH<br />
Roche Diagnostics Applied Science GmbH<br />
Roche 68298 Mannheim, Diagnostics Applied Science Germany GmbH<br />
Roche 68298 Mannheim, Applied Science Germany<br />
68298 Mannheim, Germany
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