96. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V ...

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prognostic impact was found in rectal cancer patients. The association of lymphatic invasion with the number of examined tissue blocks is an important finding that should be considered establishing practice guidelines for pathologic work-up of cancer specimens. FR-P-073 Inflammatory bowel diseases (IBD) are associated with decreased colonic expression of PEPT1 in humans and mice T . Wuensch 1 , S . Schulz2 , N . Schaltenberg1 , N . Lill1 , D . Haller1 , H . Daniel1 1Technische Universität München, ZIEL – Research Center for Nutrition and Food Science, Freising-Weihenstephan, 2Charité – Universitätsmedizin Berlin, Pathology, Berlin Aims. The intestinal peptide transporter PEPT1 is found in the brush border membrane of enterocytes in the small intestine where it contributes to amino acid absorption from luminal protein digestion. Beside that, PEPT1 is proposed to be aberrantly expressed during colonic inflammation. Because of its capability to transport bacteria-derived chemotacticacting agents such as fMLP (formyl-methionyl-leucine-phenylalanine), MDP (muramyl dipeptide) or L-Ala-D-Glu-meso-DAP, PEPT1 might act as an amplifier of inflammation. However, a systematic analysis of PEPT1 expression along the healthy colon has never been described. Here we provide information on PEPT1 mRNA and protein expression along the healthy colon of different species and during intestinal inflammation. Methods. PEPT1 mRNA and protein expression levels were determined by qRT-PCR, immunofluorescence and Western blotting, respectively, in intestinal samples from healthy mice, rats and humans. Furthermore, germ-free mice and three mouse models, resembling Crohn’s-like ileitis (TNFdeltaARE/WT) and colitis (IL-10-/-, IL- 10XTLR2-/-) as well as intestinal tissue samples from IBD patients were analyzed by immunohistochemistry. PEPT1 function in colon was determined by transport studies using [14C]-Glycyl-sarcosine (Gly-Sar). Moreover, the susceptibility of PEPT1-deficient (Pept1-/-) mice to dextran sodium sulfate (DSS)-induced colitis was investigated. Results. Colonic PEPT1 expression showed a distinct pattern of distribution with marked differences between proximal and distal segments. No PEPT1 expression was detectable in the proximal colon but prominent expression was found from mid colon to rectum of mice rats and humans. Functional Gly-Sar uptake rates were highest in jejunum and distal colon (19.76 nmol/20 min/mg protein vs. 1.71–0.42 nmol/20 min/ mg protein) and significantly lower (p
Abstracts Statistical analyses included Spearman and Mann-Whitney Rank Sum Tests (significance at p50% Ki-67 expression had a median overall survival time that was undefined, compared to with 43 months for patients with 50%) and low (
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Inhalt Der Pathologe · Supplement
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Inhalt Der Pathologe · Supplement
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Editorial Liebe Kolleginnen und Kol
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Kolorektales Karzinom 2 VO-005 Tran
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Keynote Lecture VO-014 Genetic dete
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(AMACR, FASN, GOLM1, GSP-pi, ERG) t
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to assess the correct rate of R1 re
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DNA damage, and cytotoxic drugs. Au
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HCV-positive formalin-fixed and par
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well as MET activation were examine
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or BRAF mutation, c-MYC and SIRT1 e
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AG Pneumopathologie III DO-032 Remo
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immature granulopoiesis showed a st
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ned, if well-defined mantle zones,
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phomas). Most prominent gains or am
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DO-062 Tumor-associated macrophages
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DO-080 DOG1: an immunohistochemical
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AG Oralpathologie DO-087 Detection
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DO-094 Do activated fibroblasts inf
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DO-101 Histopathological analysis o
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DO-108 Identification of potential
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Conclusions. In conclusion, 454 par
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subgroup of patients with B-Raf mut
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DO-002b Impact of terminologies in
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Methods. We performed MCPyV-FISH of
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FR-013 HPV-genotype distribution in
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Methods. Three different techniques
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(i.e. investment in equipment and e
Page 58 and 59: FR-032 COLD-PCR: a powerful tool in
Page 60 and 61: dissection (MBLND) technique to imp
Page 62 and 63: SO-005 Prevalence of mutations in s
Page 64 and 65: SO-011 Methylation profiling and in
Page 66 and 67: more effective than SAHA alone and
Page 68 and 69: SO-022 Specialized pathology review
Page 70 and 71: SO-027 Ki-67 in mitotic score group
Page 72 and 73: nificantly associated with advanced
Page 74 and 75: liver did not correlate with the mu
Page 76 and 77: AG Paidopathologie II SO-046 Overex
Page 78 and 79: Results. Histomorphology of the ova
Page 80 and 81: p42 and p27 have not yet been inves
Page 82 and 83: SO-068 Recent advances in understan
Page 84 and 85: SO-075 A novel, dual role of CCN3 i
Page 86 and 87: Pancreatic Adenocarcinoma SG-137 Se
Page 88 and 89: sease and 30 colon cancer serum sam
Page 90 and 91: Conclusions. Although CRC is charac
Page 92 and 93: differentiated and TNM stage III or
Page 94 and 95: pressed moderate levels of the prot
Page 96 and 97: FR-P-037 MALDI imaging reveals COX7
Page 98 and 99: in the context of therapy response
Page 100 and 101: on primary cells of wild-type and c
Page 102 and 103: chemotherapy was recommended and co
Page 104 and 105: aims are twofold: 1) to verify the
Page 106 and 107: Results. Her2/neu status in TMAs an
Page 110 and 111: provided information on survival ti
Page 112 and 113: Methods. Biopsy specimens from 430
Page 114 and 115: the OS rate was 53% for patients wi
Page 116 and 117: FR-P-098 Immunohistological stainin
Page 118 and 119: FR-P-104 Histopathological evaluati
Page 120 and 121: within the earliest morphologic det
Page 122 and 123: Conclusions. In primary imaging a g
Page 124 and 125: fibrotic neointma development as we
Page 126 and 127: FR-P-129 Alpha-1-antitrypsin-PiZ-an
Page 128 and 129: FR-P-136 The expression of central
Page 130 and 131: cosa and in the periarterial tissue
Page 132 and 133: FR-P-149 Combination of Castleman d
Page 134 and 135: or without different concentrations
Page 136 and 137: Results. In 18 cases (79%) the caus
Page 138 and 139: FR-P-168 Autopsy findings in a 2-ye
Page 140 and 141: FR-P-174 MPGN-like glomerulonephrit
Page 142 and 143: Poster: Gynäkopathologie und Mamma
Page 144 and 145: SA-P-011 Genetic aberrations of pre
Page 146 and 147: Mechanismen, die eine Progression d
Page 148 and 149: internet server. A network of inter
Page 150 and 151: Methods. HE-gefärbte Schnittpräpa
Page 152 and 153: Conclusions. The newly released 450
Page 154 and 155: and desmoplastic reaction are diffe
Page 156 and 157: one patient revealed more than 9 mi
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situation, the V600E mutation in th
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SA-P-064 Evolution of molecular pat
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nic markers such as myf4 and MyoD1
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Conclusions. To our knowledge, this
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SA-P-085 Expression of the eukaryot
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Results. The papillary RCC type II
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SA-P-098 Male infertility: assessme
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SA-P-104 Process oriented scientifi
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Conclusions. The IBDW offers a uniq
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L Lasitschka F. DO-046 Lehmann A. F
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96. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V ...

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