96. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V ...

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Conclusions. The IBDW offers a unique and professional service to both clinicians and researchers bringing the “two worlds together”. The highly standardized and centralized way of collecting BM and corresponding data secure top quality BM and corresponding clinical data. This will serve as a basis for high quality research within the local Medical Campus and for national and international networking. SA-P-110 A modular and virtual microscope platform based on Eclipse Technologies M . Flügge1 , N . Zerbe1 , P . Hufnagl1 1Charité – Universitätsmedizin Berlin, Institute of Pathology, Berlin Aims. Virtual microscopy is a fast growing field in histology based medical research. The base of every virtual microscopy system is digital microscope software, thus several implementations, free and commercial, are available. The main challenge of most implementations is the lack of customizability. Often the microscopes are closed in there functionality and not design to be extended by a third party. But his in turn is often required especially in research. We demonstrate a new framework that allows extending the behavior of the virtual microscope with new features in an easy and flexible way. The system is rather a base for a new virtual microscope system than a pure microscope with limit functionality. Thus it is designed with the strong focus on extensibility. Methods. To build up this extensible platform we are making an extensive use of Eclipse based technologies expressively the Rich Client Platform (RCP) architecture and the Eclipse Modeling Framework (EMF). Using the plug-in concept allows to provide a simple core which can be extended to more sophisticated applications by simply plug-in in additional functionality. As the platform in written in Java, it can be easily combined with other Java-based technologies or frameworks. Results. We demonstrate an extensible platform which allows adapting new contexts easily to the scope of virtual microscopy. Leveraging the advantages of modularizable OSGI/RCP based applications the components of the platform can be plugged together to provide highly specialized microscopes for different fields of application. This allows building up clean and non-overloaded user interface to simplify the work of pathologists. An extendible layer concept in combination with a fine grained request/notification mechanism ensures that additional functionality (e.g false color visualization) can be easily adopted leveraging automatically build-in support for zooming, panning, rotation and other editor operations. This is available for standard sized images as well as whole slide images (WSI). Image access is hidden behind an open service provider interface which allows to plug-in own implementations. Conclusions. The introduced architecture allows easy and fast integration of new functionality to the basic microscope which allows creating highly customized solutions for special field of applications in term of virtual microscopy. This reduces the costs and increases the speed of implementing such applications. SA-P-111 The BMBF Initiative to build up centralized biomaterial banks in Germany: the popgen 2.0-Network U . Nöthlings1 , A . Wolf1 , A . Rüther1 , M . Krawczak1 1Christian-Albrechts-University Kiel, Kiel Aims. Funded by the Federal Ministry of Education as one of the five facilities supported within the National Biobank Initiative, the popgen 2.0-Network (P2N) will merge seven data and probe collections currently existing at the Medical Faculty of the Christian Albrechts-University (CAU) Kiel. This network will aim towards a uniform and centralised research infrastructure which will enhance scientific usability by means of fast and easy access to vast quantities of quality-controlled data and probes that have been collected in compliance with legal and ethical regulations. Methods. Under coordination of popgen, a well established populationbased biobank, P2N will comprise the data and probes of seven collections, namely of popgen itself, the Cancer Centre North, the Department of Neurosurgery, the Institutes of Pathology and Pharmacology, the University Lung Centre North and the Centre of Family Medicine. In order to harmonise, standardise and ease access to these manifold probe types together with the both comprehensive and sensible data attached to them, P2N has performed a survey of the participating biobanks by evaluating infrastructure, workflows, probe and data types, recruitment and consent policies. In addition, P2N has analysed the portfolios of the leading laboratory information management system (LIMS) suppliers. Results. A shared network of peripheral biobanks with centralised access is merely as useful as the consistent and uniform quality of the probes and data collected and provided by the network partners. Due to the broad heterogeneity of the participating probe and data collections the usage of one common efficient albeit flexible LIMS is a crucial ingredient for a properly functioning biobank network. Equally important is a standardised handling of the probes itself and the accompanying data. Ideally, these routines must adequately be supported by the LIMS and a uniform set of SOPs. Conclusions. Within the next 5 years P2N will have set up one of Germany’s largest probe and data collections, comprising approximately probes of more than 800,000 individuals. Standardised IT and quality control infrastructures will facilitate an efficient and data safety-conform access. Der Pathologe · Supplement 1 · 2012 | 173
Autorenregister Autorenregister A Abdullah M. FR-P-131 Adam P. DO-051 Agaimy A. DO-097, DO-098, FR-P-056, FR-P-059, FR-P-154, SA-P-077, SO-058 Akpalo H. DO-080 Al-Mohamed H. FR-P-115 Andreozzi M. FR-P-128 Anlauf M. FR-003 Arend J. FR-P-055 Ates G. FR-P-164 Aulmann S. SA-P-009 Aumann K. DO-076 Aust D. VO-011 B Baldensperger M. FR-P-048 Bandapalli OR. SO-007 Barros M. DO-062 Barth PJ. SA-P-017 Barth TFE. FR-P-074 Batarello D. DO-020 Bauer K. FR-P-081 Bauer L. DO-018 Beckervordersandforth J. FR-014 Behnes CL. FR-P-170, SA-P-091, SA-P-092 Bektas Serce N. SA-P-018 Belharazem D. SA-P-067, SA-P-068 Benedix F. FR-P-076 Berchtold S. SO-009 Berezowska S. DO-016 Berg T. FR-P-173 Bergmann F. FR-P-097 Bian X-W. SG-136 Biesterfeld S. FR-P-143 Bihl MP. FR-P-060, SA-P-064 Bläker H. VO-003 Blank P. FR-P-078 Blutke A. SA-P-094 Bockmayr M. DO-078 Bockmeyer C. DO-107 Böger C. FR-P-066 Böhm F. FR-P-109 Bombari D. SO-018 Bonzheim I. DO-048 Boor P. FR-017, SO-075 Boruschek U. DO-055 Bösmüller H. SA-P-025 Brachtel E. SO-025 Brandt S. FR-P-171 Braun A. FR-P-057 Braun M. DO-111, SA-P-078, SA-P-079 Bremmer F. SA-P-100 Brochhausen C. FR-P-093, SA-P-102 Brockmoeller S. FR-011 Broecker V. SA-P-093, SO-072 Bronsert P. FR-P-091, SO-023 174 | Der Pathologe · Supplement 1 · 2012 Budczies J. FR-030 Burandt E. SO-032, SO-033 Bürger H. SA-P-006, SA-P-012 Bussmann C. VO-013 Büttner M. SA-004 C Cacchi C. FR-002 Calvisi DF. DO-006, SO-012 Carneiro F. VO-024 Cathomas M. FR-P-047 Chakilam S. SO-001 Chen Y. FR-P-132, SA-P-054 Clauditz TS. SA-P-032 Conradi L-C. FR-P-079 Cortis J. FR-P-136 Csanadi A. FR-P-133, FR-P-134 Cui T. SG-P-119, SG-135 Culemeyer L. FR-P-156 D Dach C. SA-P-106 Dämmrich M. DO-108 Datta K. VO-037 de Jonge M. FR-013 Decker T. SO-029 Dellmann A. SA-P-086 Denkert C. SO-031 Dihlmann S. DO-103 Doberenz E. SO-041 Donhuijsen K. SA-P-043 Dreyer J. DO-087 E Ehling J. SO-017 El-Baba C. SA-P-066 Elfimova N. DO-004 Elsner M. FR-P-037, FR-P-042 Erber R. SO-035 Evert M. DO-007 F Fang W-g. SA-P-015, SG-141 Fichter CD. FR-P-041 Floßbach L. DO-056, DO-057 Flügge M. DO-073, SA-P-110 Focke C. SO-027 Franken L. SO-036 Franz M. FR-P-114 Franzen A. DO-034 Frick L. FR-P-107 Friedl S. SA-P-103 Friedrich K. SA-P-014, SA-P-019 Friemel J. FR-P-099 Fritsche R. DO-120 Fronhoffs F. FR-P-162, SA-P-073, SO-054 Fuchs D. FR-P-092 Funke S. SA-P-047 G Gaida MM. DO-081 Gaisa NT. SO-065 Gaiser T. DO-023, FR-019 Gajda M. SA-P-034, SA-P-089 Gaßler N. SG-P-112, SG-128 Gdynia G. SO-006 Geddert H. FR-P-058, FR-P-075, FR-P-149, SA-P-024 Gerlach S. DO-110 Giedl C. SA-P-045 Goeppert B. FR-P-103 Göke A. FR-P-090 Göke F. DO-091, DO-093 Goltz D. DO-109, FR-P-112, FR-P-113 Gradhand E. FR-P-068 Griesser H. SO-019 Griff S. FR-P-065 Grob T. SA-P-011 Gröschl B. DO-123 Große K. FR-P-120 Grote HJ. SA-P-053 Grüning J. FR-P-167 Gündisch S. FR-027 Gutschner T. DO-033 H Haab M. SO-010 Haag J. FR-P-050 Hahn C. DO-069 Haller F. SO-014 Hammer S. SA-P-026 Hämmerle M. DO-003 Hansen T. FR-P-095, FR-P-102, FR-P-163, SA-P-033 Haroske G. DO-002b Haugg A. FR-006 Häupl B. SA-P-087 Hehne S. FR-P-147 Heikaus S. SA-P-090 Heilmann T. SO-045 Heindl S. DO-017 Helmchen B. SA-P-031 Helpap B. SA-P-081 Henopp T. FR-004, FR-005, FR-P-180 Herbach N. SA-001 Herpel E. SA-P-108 Herrmann TS. FR-P-098 Heublein S. SA-P-021 Hiemann NE. FR-P-117, FR-P-118, FR-P-119 Hirsch D. SA-P-042 Hiththetiya K. FR-P-129 Högler S. FR-P-126 Höhn AK. SA-P-099, SO-020 Höller L. FR-P-124 Höller S. SO-039 Horn L-C. SA-P-027, SA-P-030 Horst D. SG-P-114, SG-130 Hui C. FR-P-086 Huss S. SA-P-049, SA-P-058 Huth S. SG-P-130, SG-144 I Ikenberg H. FR-012, SA-P-039, SA-P-040 Ikenberg K. SA-P-028 J Jakubzik A. SA-P-097 Jarrin Franco MC. SO-021 Jayasinghe C. FR-P-071, SA-P-071 SO-052 Jiang X. SG-P-132, SG-146 Jie Z. FR-P-087 Jöhrens K. DO-063 Jonigk D. DO-032 Jungbluth A. SO-049 Just A. FR-P-053 K Kalinski T. SA-P-016 Karimi D. FR-P-036 Kayser G. DO-027, DO-068 Keck B. SO-066 Kelterborn J. FR-P-104 Kemter E. SO-069 Kettelhake A. SA-P-062 Kitz J. SO-003 Klauke M-L. SA-P-010 Klaus C. SG-P-113, SG-129 Klauschen F. SA-P-055 Kleine M. DO-112 Klempert I. FR-P-172, SA-P-101 Kloten V. SG-P-129, SG-143 Kluth M. FR-035 Knaup S. DO-115 Knöß P. DO-086 Knüchel-Clarke R. VO-019 Koitzsch U. DO-113 Kollecker I. SA-P-088 Koller K. SO-047 Kommoss S. SA-P-023, SO-022 König K. SA-P-051 Korsching E. DO-077 Kosmidis P. DO-049 Kratochvil D. FR-P-174 Krause M. VO-035 Kriegl L. DO-024 Kristiansen G. VO-020 Krüger U. FR-P-105 Küffer S. DO-125 Kuhlmann M. FR-P-168 Kuhne HP. FR-P-116 Künstlinger H. FR-033 Kurth R. FR-P-141 Küttner B. SG-P-115
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Inhalt Der Pathologe · Supplement
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Inhalt Der Pathologe · Supplement
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Editorial Liebe Kolleginnen und Kol
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Kolorektales Karzinom 2 VO-005 Tran
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Keynote Lecture VO-014 Genetic dete
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(AMACR, FASN, GOLM1, GSP-pi, ERG) t
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to assess the correct rate of R1 re
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DNA damage, and cytotoxic drugs. Au
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HCV-positive formalin-fixed and par
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well as MET activation were examine
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or BRAF mutation, c-MYC and SIRT1 e
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AG Pneumopathologie III DO-032 Remo
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immature granulopoiesis showed a st
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ned, if well-defined mantle zones,
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phomas). Most prominent gains or am
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DO-062 Tumor-associated macrophages
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DO-080 DOG1: an immunohistochemical
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AG Oralpathologie DO-087 Detection
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DO-094 Do activated fibroblasts inf
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DO-101 Histopathological analysis o
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DO-108 Identification of potential
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Conclusions. In conclusion, 454 par
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subgroup of patients with B-Raf mut
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DO-002b Impact of terminologies in
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Methods. We performed MCPyV-FISH of
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FR-013 HPV-genotype distribution in
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Methods. Three different techniques
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(i.e. investment in equipment and e
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FR-032 COLD-PCR: a powerful tool in
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dissection (MBLND) technique to imp
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SO-005 Prevalence of mutations in s
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SO-011 Methylation profiling and in
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more effective than SAHA alone and
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SO-022 Specialized pathology review
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SO-027 Ki-67 in mitotic score group
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nificantly associated with advanced
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liver did not correlate with the mu
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AG Paidopathologie II SO-046 Overex
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Results. Histomorphology of the ova
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p42 and p27 have not yet been inves
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SO-068 Recent advances in understan
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SO-075 A novel, dual role of CCN3 i
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Pancreatic Adenocarcinoma SG-137 Se
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sease and 30 colon cancer serum sam
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Conclusions. Although CRC is charac
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differentiated and TNM stage III or
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pressed moderate levels of the prot
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FR-P-037 MALDI imaging reveals COX7
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in the context of therapy response
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on primary cells of wild-type and c
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chemotherapy was recommended and co
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aims are twofold: 1) to verify the
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Results. Her2/neu status in TMAs an
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prognostic impact was found in rect
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provided information on survival ti
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Methods. Biopsy specimens from 430
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the OS rate was 53% for patients wi
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FR-P-098 Immunohistological stainin
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FR-P-104 Histopathological evaluati
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within the earliest morphologic det
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Conclusions. In primary imaging a g
Page 124 and 125: fibrotic neointma development as we
Page 126 and 127: FR-P-129 Alpha-1-antitrypsin-PiZ-an
Page 128 and 129: FR-P-136 The expression of central
Page 130 and 131: cosa and in the periarterial tissue
Page 132 and 133: FR-P-149 Combination of Castleman d
Page 134 and 135: or without different concentrations
Page 136 and 137: Results. In 18 cases (79%) the caus
Page 138 and 139: FR-P-168 Autopsy findings in a 2-ye
Page 140 and 141: FR-P-174 MPGN-like glomerulonephrit
Page 142 and 143: Poster: Gynäkopathologie und Mamma
Page 144 and 145: SA-P-011 Genetic aberrations of pre
Page 146 and 147: Mechanismen, die eine Progression d
Page 148 and 149: internet server. A network of inter
Page 150 and 151: Methods. HE-gefärbte Schnittpräpa
Page 152 and 153: Conclusions. The newly released 450
Page 154 and 155: and desmoplastic reaction are diffe
Page 156 and 157: one patient revealed more than 9 mi
Page 158 and 159: situation, the V600E mutation in th
Page 160 and 161: SA-P-064 Evolution of molecular pat
Page 162 and 163: nic markers such as myf4 and MyoD1
Page 164 and 165: Conclusions. To our knowledge, this
Page 166 and 167: SA-P-085 Expression of the eukaryot
Page 168 and 169: Results. The papillary RCC type II
Page 170 and 171: SA-P-098 Male infertility: assessme
Page 172 and 173: SA-P-104 Process oriented scientifi
Page 176 and 177: L Lasitschka F. DO-046 Lehmann A. F
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