96. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V ...

Conclusions. The IBDW offers a unique and professional service to both
clinicians and researchers bringing the “two worlds together”. The
highly standardized and centralized way of collecting BM and corresponding
data secure top quality BM and corresponding clinical data.
This will serve as a basis for high quality research within the local Medical
Campus and for national and international networking.
SA-P-110
A modular and virtual microscope platform based on Eclipse
Technologies
M . Flügge1 , N . Zerbe1 , P . Hufnagl1 1Charité – Universitätsmedizin Berlin, Institute of Pathology, Berlin
Aims. Virtual microscopy is a fast growing field in histology based medical
research. The base of every virtual microscopy system is digital
microscope software, thus several implementations, free and commercial,
are available. The main challenge of most implementations is
the lack of customizability. Often the microscopes are closed in there
functionality and not design to be extended by a third party. But his
in turn is often required especially in research. We demonstrate a new
framework that allows extending the behavior of the virtual microscope
with new features in an easy and flexible way. The system is rather a base
for a new virtual microscope system than a pure microscope with limit
functionality. Thus it is designed with the strong focus on extensibility.
Methods. To build up this extensible platform we are making an extensive
use of Eclipse based technologies expressively the Rich Client Platform
(RCP) architecture and the Eclipse Modeling Framework (EMF).
Using the plug-in concept allows to provide a simple core which can be
extended to more sophisticated applications by simply plug-in in additional
functionality. As the platform in written in Java, it can be easily
combined with other Java-based technologies or frameworks.
Results. We demonstrate an extensible platform which allows adapting
new contexts easily to the scope of virtual microscopy. Leveraging the
advantages of modularizable OSGI/RCP based applications the components
of the platform can be plugged together to provide highly specialized
microscopes for different fields of application. This allows building
up clean and non-overloaded user interface to simplify the work of
pathologists. An extendible layer concept in combination with a fine
grained request/notification mechanism ensures that additional functionality
(e.g false color visualization) can be easily adopted leveraging
automatically build-in support for zooming, panning, rotation and other
editor operations. This is available for standard sized images as well
as whole slide images (WSI). Image access is hidden behind an open service
provider interface which allows to plug-in own implementations.
Conclusions. The introduced architecture allows easy and fast integration
of new functionality to the basic microscope which allows creating
highly customized solutions for special field of applications in term of
virtual microscopy. This reduces the costs and increases the speed of
implementing such applications.
SA-P-111
The BMBF Initiative to build up centralized biomaterial banks in
Germany: the popgen 2.0-Network
U . Nöthlings1 , A . Wolf1 , A . Rüther1 , M . Krawczak1 1Christian-Albrechts-University Kiel, Kiel
Aims. Funded by the Federal Ministry of Education as one of the five
facilities supported within the National Biobank Initiative, the popgen
2.0-Network (P2N) will merge seven data and probe collections currently
existing at the Medical Faculty of the Christian Albrechts-University
(CAU) Kiel. This network will aim towards a uniform and centralised
research infrastructure which will enhance scientific usability
by means of fast and easy access to vast quantities of quality-controlled
data and probes that have been collected in compliance with legal and
ethical regulations.
Methods. Under coordination of popgen, a well established populationbased
biobank, P2N will comprise the data and probes of seven collections,
namely of popgen itself, the Cancer Centre North, the Department
of Neurosurgery, the Institutes of Pathology and Pharmacology,
the University Lung Centre North and the Centre of Family Medicine.
In order to harmonise, standardise and ease access to these manifold
probe types together with the both comprehensive and sensible data
attached to them, P2N has performed a survey of the participating biobanks
by evaluating infrastructure, workflows, probe and data types,
recruitment and consent policies. In addition, P2N has analysed the
portfolios of the leading laboratory information management system
(LIMS) suppliers.
Results. A shared network of peripheral biobanks with centralised access
is merely as useful as the consistent and uniform quality of the probes
and data collected and provided by the network partners. Due to the
broad heterogeneity of the participating probe and data collections the
usage of one common efficient albeit flexible LIMS is a crucial ingredient
for a properly functioning biobank network. Equally important is
a standardised handling of the probes itself and the accompanying data.
Ideally, these routines must adequately be supported by the LIMS and a
uniform set of SOPs.
Conclusions. Within the next 5 years P2N will have set up one of Germany’s
largest probe and data collections, comprising approximately
probes of more than 800,000 individuals. Standardised IT and quality
control infrastructures will facilitate an efficient and data safety-conform
access.
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